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GENE：HMGB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMGB1
FullNmae high mobility group box 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4983
EnsembleID ENSG00000189403
Uniprot P09429

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMGB1 pyroptosis 32419317 The TNF-α/HMGB1 inflammation signalling pathway plays an important role in pyroptosis during ALF and AKI. retulator signature
HMGB1 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HMGB1 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGB1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGB1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HMGB1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
HMGB1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGB1 autophagy 38007142 High-mobility group box 1 (HMGB1), a nonhistone chromosomal protein, plays a pivotal role in coordinating autophagy and apoptosis levels during tumor initiation, progression, and therapy. retulator signature
HMGB1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HMGB1 GO:0000122,GO:0000122,GO:0000122,GO:0000400,GO:0000405,GO:0000793,GO:0000976,GO:0001530,GO:0001773,GO:0001786,GO:0002218,GO:0002407,GO:0002437,GO:0002643,GO:0002840,GO:0003684,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003714,GO:0003723,GO:0005125,GO:0005178,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005634,GO:0005654,GO:0005768,GO:0005783,GO:0005793,GO:0006265,GO:0006303,GO:0006310,GO:0006357,GO:0006914,GO:0006954,GO:0007165,GO:0007204,GO:0008301,GO:0008301,GO:0008301,GO:0009986,GO:0010508,GO:0016829,GO:0017053,GO:0017055,GO:0019958,GO:0031175,GO:0031507,GO:0032072,GO:0032392,GO:0032425,GO:0032689,GO:0032732,GO:0032733,GO:0032735,GO:0032755,GO:0032757,GO:0032760,GO:0033151,GO:0034165,GO:0034774,GO:0035711,GO:0035868,GO:0042056,GO:0042104,GO:0043065,GO:0043277,GO:0043280,GO:0043371,GO:0043388,GO:0043410,GO:0043536,GO:0043537,GO:0045063,GO:0045087,GO:0045944,GO:0046330,GO:0046598,GO:0048018,GO:0050786,GO:0050918,GO:0051106,GO:0061629,GO:0070182,GO:0070374,GO:0071222,GO:0090026,GO:0097100,GO:0097350,GO:0140297,GO:1904813,GO:1905564,GO:2000343,GO:2000426,GO:2001200

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HMGB1 hsa:3146 path:hsa03410 Base excision repair - Homo sapiens (human)
HMGB1 hsa:3146 path:hsa04140 Autophagy - animal - Homo sapiens (human)
HMGB1 hsa:3146 path:hsa04217 Necroptosis - Homo sapiens (human)
HMGB1 hsa:3146 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HMGB1 BAG6 12646658 15802534 19931333 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 HAVCR2 12646658 15802534 19931333 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 FYN 12646658 15802534 19931333 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 CD74 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 CCR7 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 LY96 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 TIRAP 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 MYD88 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 CD14 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 TLR2 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 TLR4 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 CXCR4 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
IL18 HMGB1 10679398 10952726 11592085 11672593 12646658 12803886 14504095 14662834 15099563 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 26885855 27048821 27066895 27192565 9469432 interaction type N/A ACSN
IFNG HMGB1 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
TNF HMGB1 10925299 11112697 11438547 11875494 12646658 12811837 1431106 14607933 14625680 15099563 15699106 16713974 17916596 18633355 19411070 20038811 20184663 20435894 21133840 21411734 21826665 22595692 22955274 23170255 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 8910423 interaction type N/A ACSN
HMGB1 TGFB1 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26192618 26618107 27048821 27192565 interaction type N/A ACSN
HMGB1 KPNA1 17114460 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMGB1 TLR9 17417641 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMGB1 IL1B 18250463 23180781 physical association anti tag coimmunoprecipitation InnateDB
HMGB1 HNF1A 18160415 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
HMGB1 AFP 18160415 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
HMGB1 AGER 19727205 23180781 physical association solid phase assay InnateDB
CDK2 HMGB1 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
TPSAB1 HMGB1 23180781 24257755 protein cleavage protease assay InnateDB
CMA1 HMGB1 23180781 24257755 protein cleavage protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 HMGB1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 HMGB1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 HMGB1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 HMGB1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 HMGB1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HMGB1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HMGB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFIC HMGB1 11245470 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HMGB1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB HMGB1 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU3F1 HMGB1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 HMGB1 17637574 rna interference,inhibition experimental interaction detection miRSponge
URS0000096022 HMGB1 23303785 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000096022 HMGB1 23303785 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 HMGB1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D HMGB1 23622248 23824327 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000013DD8 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E HMGB1 23313552 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS0000236310 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000521626 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005FDE70 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000029979D HMGB1 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS00003BBF48 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 HMGB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003677B2 HMGB1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041E949 HMGB1 21572407 23313552 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 HMGB1 21572407 23313552 23446348 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 HMGB1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BD1DE HMGB1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 HMGB1 21572407 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 HMGB1 21572407 23313552 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A HMGB1 21572407 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 HMGB1 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000E7139 HMGB1 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000358C16 HMGB1 20371350 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001E0AEA HMGB1 20371350 25416803 26617792 26721185 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000006A1CB HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000171020 HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00007455B8 HMGB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005E6F45 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 HMGB1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD HMGB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A HMGB1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F HMGB1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC HMGB1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000018D2BE HMGB1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D HMGB1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 HMGB1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 HMGB1 25416803 26183718 mrna cleavage,inhibition experimental interaction detection,nucleotide sequence identification,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D HMGB1 25327529 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000367985 HMGB1 25416803 28276476 mrna cleavage,inhibition array technology,western blot,miRNA interference luciferase reporter assay TarBase
URS00003CF1AD HMGB1 25416803 28317284 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008DA94 HMGB1 25416803 28403886 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 HMGB1 25416803 27456356 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000157F5 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B2B5C HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C6C6F HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065FDF HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000118224 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004283FE HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000D2680 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008AA34 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000043D2C1 HMGB1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TP53 HMGB1 25361965 interaction type N/A PTMCode2
HMGB1 TP53 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK HMGB1 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TFAP4 HMGB1 25348397 N/A physical interaction ComPPI
SMARCE1 HMGB1 25348397 N/A physical interaction ComPPI
HSPA8 HMGB1 25348397 N/A physical interaction ComPPI
POLB HMGB1 17803946 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GTF2A1 HMGB1 25348397 N/A physical interaction ComPPI
MAP1LC3B HMGB1 23303669 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
HMGB2 HMGB1 25348397 N/A physical interaction ComPPI
HMGB1 PRKCA 10617144 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 CUX1 25348397 N/A in vitro ComPPI
HMGB1 TLR2 14525934 16267105 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HMGB1 UNC119 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HMGB1 LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
HMGB1 TLR4 14525934 16267105 20547845 24234451 25348397 physical association experimental interaction detection,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
HMGB1 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HMGB1 CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HMGB1 DNMT1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 HES1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 HOXD9 14525934 25348397 8890171 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB1 RBPJ 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 IRF2 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 NFKB1 12604365 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 RELA 12665595 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
HMGB1 POU5F1 11099378 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB1 PLG 14525934 1909331 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 PLAT 14525934 1909331 25348397 27898060 8366113 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
HMGB1 RAG1 10490593 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB1 RB1 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 CEBPB 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 ZFP36 25348397 N/A in vitro ComPPI
HMGB1 MECP2 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 TAF1 11748221 14525934 25348397 9880542 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 AR 11748221 14525934 25348397 9671457 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB1 TFE3 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 RFX1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 TBP 14525934 24234451 25348397 8006019 9880542 physical association experimental interaction detection,physical interaction,biochemical,in vitro ComPPI,HPRD,IntAct
HMGB1 TLE5 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 TLE1 11748221 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 AGER 14525934 24234451 24474694 25348397 9812979 N/A experimental interaction detection,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
HMGB1 CASP3 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 NCAN 14525934 25348397 9507007 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB1 PRKDC 14525934 25348397 9722660 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 TLE2 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 FOXC1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 ATOH1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 TP73 11748232 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
HMGB1 FOXA3 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 HR 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 TGIF1 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 MNT 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 CTCF 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 SOX18 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 SIX5 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 PPP2R3A 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 ERF 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 NEUROD6 11748221 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB1 RASSF4 25348397 N/A in vitro ComPPI
HMGB1 CSNK1A1 12062430 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique ComPPI,HPRD,IntAct
HMGB1 TP53 11106654 11748221 14525934 23063560 24234451 25348397 9472015 physical association affinity chromatography technology,cross-linking study,experimental interaction detection,far western blotting,isothermal titration calorimetry,molecular sieving,nuclear magnetic resonance,physical interaction ComPPI,HPRD,IntAct
HMGB1 HOXB1 25348397 N/A physical interaction ComPPI
HMGB1 HOXB3 25348397 N/A physical interaction ComPPI
HMGB1 HOXC6 25348397 N/A physical interaction ComPPI
HMGB1 HOXD3 25348397 N/A physical interaction ComPPI
HMGB1 HOXD8 25348397 N/A physical interaction ComPPI
HMGB1 HOXD10 25348397 N/A physical interaction ComPPI
HMGB1 HOXD11 25348397 N/A physical interaction ComPPI
HMGB1 LPA 25348397 N/A physical interaction ComPPI
HMGB1 PTPRZ1 25348397 N/A physical interaction ComPPI
HMGB1 PGR 25348397 N/A physical interaction ComPPI
HMGB1 NR3C1 25348397 N/A physical interaction ComPPI
HMGB1 CDK1 2013279 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HMGB1 CREBBP 25348397 N/A physical interaction ComPPI
HMGB1 PDIA3 25348397 N/A physical interaction ComPPI
HMGB1 DNM2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HMGB1 TERF2IP 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
HMGB1 TERF2 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
HMGB1 CDK2 25348397 N/A physical interaction ComPPI
HMGB1 XPC 25348397 N/A physical interaction ComPPI
HMGB1 RAD23B 25348397 N/A physical interaction ComPPI
HMGB1 PSEN1 25348397 N/A physical interaction ComPPI
HMGB1 SSRP1 25348397 N/A physical interaction ComPPI
HMGB1 HNF1A 25348397 N/A physical interaction ComPPI
HMGB1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
HMGB1 ITGA4 25348397 N/A physical interaction ComPPI
HMGB1 HMGA1 25348397 N/A filter binding,physical interaction ComPPI
HMGB1 ZNF24 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
HMGB1 MAPK1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HMGB1 ASB1 25348397 N/A physical interaction ComPPI
HMGB1 ASB2 25348397 N/A physical interaction ComPPI
HMGB1 HUWE1 25348397 N/A physical interaction ComPPI
HMGB1 AGTRAP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HMGB1 WDR76 25348397 N/A physical interaction ComPPI
HMGB1 SMARCA2 25348397 N/A physical interaction ComPPI
HMGB1 SMARCA4 25348397 N/A physical interaction ComPPI
HMGB1 SMARCD1 25348397 N/A physical interaction ComPPI
HMGB1 SMARCD3 25348397 N/A physical interaction ComPPI
HMGB1 SUPT16H 25348397 N/A physical interaction ComPPI
HMGB1 NTRK1 25348397 N/A physical interaction ComPPI
HMGB1 CTDP1 25348397 N/A physical interaction ComPPI
HMGB1 EWSR1 25348397 N/A physical interaction ComPPI
HMGB1 UFD1 25348397 N/A physical interaction ComPPI
HMGB1 U2AF2 25348397 N/A physical interaction ComPPI
HMGB1 PARP1 25348397 N/A physical interaction ComPPI
HMGB1 HPF1 25348397 N/A physical interaction ComPPI
HMGB1 EGFR 25348397 N/A physical interaction ComPPI
HMGB1 CDC14B 25348397 N/A physical interaction ComPPI
HMGB1 SP100 25348397 N/A physical interaction ComPPI
HMGB1 POTEE 25348397 N/A physical interaction ComPPI
HMGB1 ATP2A1 25348397 N/A physical interaction ComPPI
HMGB1 GFAP 25348397 N/A physical interaction ComPPI
HMGB1 TUBA3C 25348397 N/A physical interaction ComPPI
HMGB1 UBE2N 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HMGB1 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HMGB1 IL1B 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HMGB1 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HMGB1 TXN 18996119 24234451 25348397 27898060 disulfide bond nuclear magnetic resonance ComPPI,IntAct,OmniPath
HMGB1 ETS1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HMGB1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
HMGB1 BECN1 20819940 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 LY96 20547845 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
HMGB1 HTT 23303669 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy,proximity ligation assay ComPPI,IntAct
HMGB1 MLH1 15014079 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 MSH2 15014079 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
HMGB1 APEX1 17803946 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 DUX4 24234451 25348397 26816005 association pull down ComPPI,IntAct
HMGB1 CCNDBP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMGB1 BCAR1 24234451 25348397 28007913 association anti bait coimmunoprecipitation ComPPI,IntAct
HMGB1 PPTC7 24234451 25348397 28330616 association pull down ComPPI,IntAct
XPA HMGB1 25348397 N/A physical interaction ComPPI
H3C1 HMGB1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H3-3A HMGB1 25348397 N/A physical interaction ComPPI
KPNA6 HMGB1 25348397 N/A physical interaction ComPPI
HMGB1 CUX1 11748221 14525934 N/A experimental interaction detection HPRD
HMGB3 HMGB1 24234451 30021884 physical association cross-linking study IntAct
HMGB1 KPNA1 17114460 27898060 N/A N/A OmniPath
HMGB1 TLR4 16267105 20547845 27898060 stimulant N/A OmniPath
TLR9 HMGB1 17417641 27898060 N/A N/A OmniPath
HMGB1 BECN1 20819940 27898060 inhibition N/A OmniPath
BECN1 HMGB1 20819940 27898060 stimulant N/A OmniPath
IL1B HMGB1 18250463 27898060 N/A N/A OmniPath
HMGB1 SDC1 1369684 27898060 N/A N/A OmniPath
HMGB1 THBD 15841214 27898060 N/A N/A OmniPath

Visualization










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