Gene Information gene info

  1. Home

GENE：TYK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TYK2
FullNmae tyrosine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12440
EnsembleID ENSG00000105397
Uniprot P29597

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TYK2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TYK2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TYK2 GO:0004713,GO:0004713,GO:0004713,GO:0004715,GO:0004715,GO:0004715,GO:0005131,GO:0005131,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0006468,GO:0006955,GO:0007259,GO:0007259,GO:0009898,GO:0019221,GO:0019221,GO:0019897,GO:0030154,GO:0031702,GO:0032729,GO:0032740,GO:0032819,GO:0035556,GO:0035722,GO:0038196,GO:0042022,GO:0042102,GO:0046427,GO:0051142,GO:0051142,GO:0060333,GO:0060337,GO:0060337,GO:0060337,GO:0060397,GO:0070062,GO:0072536,GO:0098586,GO:1900182,GO:2000318

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TYK2 hsa:7297 path:hsa04217 Necroptosis - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
TYK2 hsa:7297 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05160 Hepatitis C - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05161 Hepatitis B - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05162 Measles - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05164 Influenza A - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
TYK2 hsa:7297 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JAK1 TYK2 10022928 10415122 10433356 10485906 10542212 10542297 10623821 10982844 11160275 11207245 11306493 11371360 11694501 11698286 11867689 11870632 11875494 11964292 12087100 12223527 12401408 12469119 12496409 12734330 12754507 12811837 12818165 1439146 14607900 14610620 14657224 14764663 14764690 14764699 15099563 15120653 15166220 15282297 15312780 15356132 15449939 15573129 15579430 15864272 16171819 16200688 16243976 16413922 16424049 16713974 16982608 16987978 17351669 17404308 17485448 17513775 17969444 18209571 18250477 1825141 18389480 18451175 18508557 18555777 18555778 18830264 19457860 19581928 19833085 20138012 20184663 20406969 20462497 20510870 20671117 20856220 21097505 21115385 21191065 21220452 21469115 21716315 21840487 21930765 21930769 22383755 22595692 23034983 23124025 23291588 23390297 23567181 23704922 24011634 24030977 24091328 24243840 24346288 24418198 25002027 25582338 26192618 26201938 26268945 26755705 27216177 27557510 29145629 2965306 7512720 7521688 7526154 7543512 7590867 8197134 8232552 8605876 8621447 8702790 8837607 8910398 8943354 9312047 9334213 9535722 9822675 9834059 9845545 interaction type,physical association inferred by curator ACSN,Reactome
JAK2 TYK2 10485906 10807786 11160275 11306493 11371360 11867689 11870632 12223527 12244147 12372421 12401408 12496409 12754507 12818165 1439146 14610620 14657224 15099563 15356132 15546391 15573129 16243976 16413922 17404308 17485448 18209571 18250477 1825141 18451175 18555777 18555778 19581928 19833085 20138012 20184663 20406969 20510870 20856220 21042762 21097505 21115385 21469115 21840487 22077060 22595692 23034983 23124025 23390297 23567181 24011634 24030977 24091328 24204259 24346288 24418198 25002027 25582338 26192618 26201938 26268945 26755705 27216177 27557510 2965306 7512720 7521688 7543512 7590867 8683106 8700208 8837607 9535722 9834059 9845545 interaction type N/A ACSN
TYK2 IL6R 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 22595692 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TYK2 IL12RB1 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN
TYK2 IL12RB2 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN
TYK2 IFNAR1 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 26192618 7512720 7521688 7543512 interaction type N/A ACSN
TYK2 IFNAR2 11207245 11698286 11964292 12811837 14610620 14764699 15864272 17513775 19833085 21115385 21840487 21930765 21930769 26192618 7512720 7521688 7543512 interaction type N/A ACSN
TYK2 IL13 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
TYK2 IL13RA1 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23180781 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type,physical association unspecified method ACSN,InnateDB
TYK2 IL4R 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 1825141 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 2965306 7512720 7521688 7543512 9535722 9834059 interaction type N/A ACSN
TYK2 IL4 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10RA 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL10RB 10433356 10542212 10623821 11207245 11875494 12818165 14607900 14610620 15282297 15579430 15833879 16200688 16424049 16713974 17404308 19833085 20184663 21115385 21191065 21220452 21840487 26192618 26755705 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL6 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
TYK2 STAT3 10542297 11306493 11867689 12023369 12626585 12754507 1439146 14565860 14610620 14764663 15099563 15261459 15356132 15573129 18209571 18389480 18555777 18555778 19581928 19833085 20138012 20406969 21098725 21115385 21840487 23034983 23124025 23331499 23567181 23673666 24011634 24091328 24346288 24418198 25002027 25516297 25582338 26192618 26201938 26268945 27216177 27557510 29145629 7512720 7521688 7543512 7590867 8662928 8837607 9845545 interaction type,stimulation,physical association inferred by curator ACSN,Reactome,SignaLink
OSM TYK2 16204061 21840487 26192618 interaction type N/A ACSN
TYK2 STAT1 10918587 10982844 11207245 11294897 11698286 11839738 11964292 12637327 12811837 12817007 14565860 14610620 14764663 14764699 15261459 15322115 15864272 17513775 18389480 18988627 19833085 21115385 21840487 21930765 21930769 23124025 23331499 24243840 26192618 29145629 7512720 7521688 7543024 7543512 7657660 7690989 8232552 8780896 interaction type,stimulation,physical association inferred by curator ACSN,Reactome,SignaLink,SignaLink
TYK2 STAT6 10485906 11867689 12223527 12401408 14610620 14657224 15099563 16243976 16413922 17404308 17485448 18250477 18451175 19833085 20184663 20406969 20510870 20856220 21097505 21115385 21469115 21840487 23124025 23390297 24030977 24091328 26192618 26755705 27216177 7512720 7521688 7543512 9535722 interaction type N/A ACSN
TYK2 IL18 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20856220 21115385 21840487 23124025 23390297 24030977 24091328 26192618 27216177 2965306 7512720 7521688 7543512 9834059 interaction type N/A ACSN
TYK2 IL15 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
TYK2 IL15RA 10820393 11207245 11698286 11964292 12811837 14607946 14610620 14764699 15864272 16212621 16815076 17398124 17459805 17513775 19833085 19913445 20007590 20856220 21115385 21307131 21840487 21930765 21930769 23124025 24829413 25582338 26192618 7512720 7521688 7523571 7543512 interaction type N/A ACSN
TYK2 STAT4 10807786 11867689 12244147 12372421 14610620 15546391 16324152 19833085 20406969 21042762 21115385 22077060 23331499 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type,stimulation N/A ACSN,SignaLink
TYK2 TNF 11306493 11867689 12754507 1439146 14610620 15099563 15356132 15573129 18209571 18555777 18555778 19581928 19833085 20138012 20406969 21115385 21840487 23034983 23567181 24011634 24091328 24346288 24418198 25002027 25582338 26192618 26201938 26268945 27216177 27557510 7512720 7521688 7543512 7590867 8837607 9845545 interaction type N/A ACSN
IFNAR1 TYK2 14647450 15120645 15337770 23180781 23331499 24243840 29145629 7559568 8524272 8605876 8702790 9461596 9733772 phosphorylation reaction,stimulation,physical association anti tag coimmunoprecipitation,gst pull down,pull down,inferred by curator,in-gel kinase assay InnateDB,Reactome,SignaLink,SignaLink
TYK2 TYK2 10433356 16982608 23180781 29145629 7543512 8702790 8910398 9312047 physical association inferred by curator,in-gel kinase assay InnateDB,Reactome
PTPN6 TYK2 14624462 18508557 23180781 23331499 29145629 8524272 8943354 dephosphorylation reaction,inhibition,physical association anti tag coimmunoprecipitation,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
TYK2 JAK3 12207328 23180781 physical association anti tag coimmunoprecipitation InnateDB
TYK2 PTAFR 11309383 14500680 23180781 physical association anti tag coimmunoprecipitation InnateDB
TYK2 RACK1 15240704 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
VAV1 TYK2 23180781 9038355 physical association anti tag coimmunoprecipitation InnateDB
TYK2 STAT5A 23180781 23331499 9872990 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
TYK2 STAT5B 23180781 9872990 physical association anti tag coimmunoprecipitation InnateDB
TYK2 PTPN11 23180781 9794795 physical association anti tag coimmunoprecipitation InnateDB
TYK2 LYN 23180781 9633884 physical association protein kinase assay InnateDB
TYK2 EIF2AK2 23180781 23236554 physical association anti tag coimmunoprecipitation InnateDB
TYK2 STAT2 10022928 10542297 10982844 11694501 12040185 15312780 15449939 16171819 16987978 17351669 17969444 18508557 18988627 23331499 24243840 29145629 7526154 8197134 8232552 8605876 8605877 8621447 8702790 8943354 9334213 stimulation,physical association inferred by curator Reactome,SignaLink,SignaLink
PTPN1 TYK2 11694501 23331499 29145629 dephosphorylation reaction,stimulation inferred by curator Reactome,SignaLink,SignaLink
IFNB1 TYK2 10542297 23331499 stimulation N/A SignaLink,SignaLink
IFNAR2 TYK2 12040185 12960323 18988627 23331499 stimulation N/A SignaLink,SignaLink
IL20RA TYK2 12941475 23331499 stimulation N/A SignaLink,SignaLink
IL22RA1 TYK2 12941475 23331499 stimulation N/A SignaLink,SignaLink
IL10RA TYK2 12974481 23331499 stimulation N/A SignaLink,SignaLink
COPS5 TYK2 24043623 phosphorylation reaction,stimulation N/A SignaLink
MPL TYK2 23331499 7543416 stimulation N/A SignaLink
IL13RA1 TYK2 10409622 23331499 8609418 stimulation N/A SignaLink
CSF3R TYK2 23331499 9015216 stimulation N/A SignaLink
GHR TYK2 10502458 23331499 stimulation N/A SignaLink
IL6ST TYK2 10929036 23331499 9388212 stimulation N/A SignaLink
LIFR TYK2 11294841 23331499 stimulation N/A SignaLink
IL23R TYK2 12023369 23331499 stimulation N/A SignaLink
IL20RB TYK2 12941475 23331499 stimulation N/A SignaLink
IL10RB TYK2 12974481 23331499 stimulation N/A SignaLink
IFNLR1 TYK2 15120645 23331499 stimulation N/A SignaLink
LEPR TYK2 17228025 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
IRS1 TYK2 20005715 interaction type N/A PSP,SignaLink
IRS2 TYK2 18988627 20005715 8550573 interaction type N/A PSP,SignaLink
PIK3R1 TYK2 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 TYK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TYK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR TYK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 TYK2 18550668 trascriptional regulation,stimulation inferred by curator TFlink
MYC TYK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
TYK2 RACK1 22135298 phosphorylation N/A PhosphoSite
TYK2 IFNAR1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
TYK2 TYK2 22135298 phosphorylation N/A PhosphoSite
TYK2 SIVA1 22135298 phosphorylation N/A PhosphoSite
IL12RB2 TYK2 25361965 interaction type N/A PTMCode2
TYK2 IL12RB2 25361965 interaction type N/A PTMCode2
IFNAR1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 PTAFR 25361965 interaction type N/A PTMCode2
PTAFR TYK2 25361965 interaction type N/A PTMCode2
TYK2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 IL6ST 25361965 interaction type N/A PTMCode2
IL6ST TYK2 25361965 interaction type N/A PTMCode2
TYK2 PLAUR 25361965 interaction type N/A PTMCode2
PLAUR TYK2 25361965 interaction type N/A PTMCode2
TYK2 JAK1 25361965 interaction type N/A PTMCode2
JAK1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 CRKL 25361965 interaction type N/A PTMCode2
CRKL TYK2 25361965 interaction type N/A PTMCode2
TYK2 FYN 25361965 interaction type N/A PTMCode2
FYN TYK2 25361965 interaction type N/A PTMCode2
TYK2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 IL13RA1 25361965 interaction type N/A PTMCode2
IL13RA1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 IRS2 25361965 interaction type N/A PTMCode2
IRS2 TYK2 25361965 interaction type N/A PTMCode2
TYK2 JAKMIP1 25361965 interaction type N/A PTMCode2
JAKMIP1 TYK2 25361965 interaction type N/A PTMCode2
TYK2 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 TYK2 25361965 interaction type N/A PTMCode2
GHR TYK2 25361965 interaction type N/A PTMCode2
TYK2 GHR 25361965 interaction type N/A PTMCode2
CBL TYK2 25361965 interaction type N/A PTMCode2
TYK2 CBL 25361965 interaction type N/A PTMCode2
STAM2 TYK2 25361965 interaction type N/A PTMCode2
TYK2 STAM2 25361965 interaction type N/A PTMCode2
EIF2AK2 TYK2 25361965 interaction type N/A PTMCode2
TYK2 EIF2AK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPK TYK2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FHL3 TYK2 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GMNN TYK2 25348397 N/A physical interaction ComPPI
STAT1 TYK2 10918587 11294897 11839738 12637327 12817007 14525934 15322115 25348397 7543024 7657660 7690989 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TK1 TYK2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TYK2 KHDRBS2 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TYK2 KRT40 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TYK2 VAV1 10673353 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 LYN 14525934 25348397 9633884 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TYK2 CBL 14525934 25348397 8780698 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 PIK3R1 10995743 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TYK2 IFNAR1 10523853 14525934 24234451 25348397 95059042 9677371 9733772 physical association experimental interaction detection,molecular sieving,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TYK2 PTPN6 14525934 25348397 7629131 8780698 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 PTPN1 11694501 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TYK2 RACK1 12960323 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 IL13RA1 10409622 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 IL6ST 14525934 25348397 9388212 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 IRS2 14525934 25348397 8550573 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 GHR 10502458 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 CRKL 14525934 25348397 9374471 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 PRMT5 10531356 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
TYK2 STAM2 10899310 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 XRCC5 10673353 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 PLAUR 14525934 25348397 9974409 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 PTAFR 14500680 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 PDGFRB 14525934 25348397 8657151 9484840 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TYK2 STAT2 14525934 25348397 8605877 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TYK2 JAKMIP1 14525934 15277531 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TYK2 EIF2AK2 14525934 17290288 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TYK2 FYN 14525934 25348397 9196040 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 IRS1 14525934 25348397 8550573 N/A experimental interaction detection,in vivo ComPPI,HPRD
TYK2 JAK1 14525934 25348397 7589562 8702790 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TYK2 PTPRC 25348397 N/A in vitro ComPPI
TYK2 ELP2 25348397 N/A physical interaction ComPPI
TYK2 DNM2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TYK2 SOCS1 25348397 N/A physical interaction ComPPI
TYK2 KLF10 25348397 N/A physical interaction ComPPI
TYK2 LNX1 25348397 N/A physical interaction ComPPI
TYK2 HSP90AA1 25348397 N/A physical interaction ComPPI
TYK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
TYK2 JAK3 25348397 N/A physical interaction ComPPI
TYK2 COPS5 24043623 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TYK2 TRAF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TYK2 SIVA1 25348397 N/A physical interaction ComPPI
TYK2 SHMT2 25348397 N/A physical interaction ComPPI
TYK2 MOV10 25348397 N/A physical interaction ComPPI
TYK2 NXF1 25348397 N/A physical interaction ComPPI
TYK2 BAG2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT3 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT4 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT5 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT6A 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT7 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CCT8 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 DDX5 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 HNRNPH1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 HSPB1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 CEP170B 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 RAN 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 RUVBL1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 RUVBL2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 SLC2A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 ALYREF 25348397 N/A physical interaction ComPPI
TYK2 TRIM28 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 TUBA4A 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 WDR20 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TYK2 EFNB2 25348397 N/A physical interaction ComPPI
TYK2 PIH1D1 25348397 N/A physical interaction ComPPI
TYK2 TGFBR2 25348397 N/A physical interaction ComPPI
TYK2 LRRC46 25348397 N/A physical interaction ComPPI
TYK2 LPAR6 25348397 N/A physical interaction ComPPI
TYK2 RNF13 25348397 N/A physical interaction ComPPI
TYK2 ZNF333 25348397 N/A physical interaction ComPPI
TYK2 MIER2 25348397 N/A physical interaction ComPPI
TYK2 SIAH2 25348397 N/A physical interaction ComPPI
TYK2 UBE2L6 25348397 N/A physical interaction ComPPI
TYK2 LRP8 25348397 N/A physical interaction ComPPI
TYK2 IFT43 25348397 N/A physical interaction ComPPI
TYK2 PMEL 25348397 N/A physical interaction ComPPI
TYK2 TNFRSF19 25348397 N/A physical interaction ComPPI
TYK2 IL4R 25348397 N/A physical interaction ComPPI
TYK2 TMCO3 25348397 N/A physical interaction ComPPI
TYK2 GPR156 25348397 N/A physical interaction ComPPI
TYK2 CDH8 25348397 N/A physical interaction ComPPI
TYK2 CD79A 25348397 N/A physical interaction ComPPI
TYK2 TNFRSF13B 25348397 N/A physical interaction ComPPI
TYK2 HAVCR2 25348397 N/A physical interaction ComPPI
TYK2 PROSER2 25348397 N/A physical interaction ComPPI
TYK2 LGALS3BP 25348397 N/A physical interaction ComPPI
TYK2 DNAAF8 25348397 N/A physical interaction ComPPI
TYK2 MAS1 25348397 N/A physical interaction ComPPI
TYK2 NLGN3 25348397 N/A physical interaction ComPPI
TYK2 HNRNPL 25348397 N/A physical interaction ComPPI
TYK2 PRKCA 17290288 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TYK2 UBE2F 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
TYK2 HSP90AB1 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
TYK2 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
TYK2 JAK2 24234451 25348397 26175413 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TYK2 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TYK2 KRT31 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TYK2 KHDRBS3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TYK2 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TCP1 TYK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IFNAR2 TYK2 12960323 14525934 N/A experimental interaction detection HPRD
TYK2 TYK2 14525934 7589562 N/A experimental interaction detection HPRD
TYK2 MARCKS 16116087 1650359 27898060 N/A N/A OmniPath
LYN TYK2 27898060 9633884 N/A N/A OmniPath
PTPN1 TYK2 11694501 15780598 27898060 inhibition,stimulant N/A OmniPath
TYK2 RACK1 12960323 15240704 27898060 N/A N/A OmniPath
RACK1 TYK2 12960323 15240704 27898060 N/A N/A OmniPath
CSF3R TYK2 27898060 9015216 stimulant N/A OmniPath
EIF2AK2 TYK2 17290288 23236554 27898060 N/A N/A OmniPath
JAK3 TYK2 12207328 27898060 N/A N/A OmniPath
IL6ST TYK2 10929036 27898060 9388212 stimulant N/A OmniPath
TYK2 STAT5A 27898060 9872990 stimulant N/A OmniPath
TYK2 SIVA1 20727854 27898060 N/A N/A OmniPath
PTPN6 TYK2 14624462 27898060 7629131 8524272 8780698 inhibition N/A OmniPath
TYK2 STAT1 10435617 10918587 11294897 11839738 12637327 12817007 15322115 27898060 7543024 7657660 7690989 8780896 stimulant N/A OmniPath
TYK2 IL10RA 10433356 27898060 N/A N/A OmniPath
IL10RA TYK2 12974481 27898060 stimulant N/A OmniPath
IFNAR1 TYK2 10523853 14647450 15120645 15337770 15356134 18474601 24704786 27898060 7526154 7559568 8524272 8605876 8628273 8702790 9461596 95059042 9677371 9733772 stimulant N/A OmniPath
TYK2 IFNAR1 10523853 11786546 12220192 14647450 15120645 15337770 15356134 18474601 23129613 24704786 27898060 7526154 7559568 8524272 8605876 8628273 8700538 8702790 9121453 9461596 95059042 9677371 9733772 stimulant N/A OmniPath
LEPR TYK2 17228025 27898060 stimulant N/A OmniPath
JAK1 TYK2 19901323 27898060 7504784 7589562 8702790 stimulant N/A OmniPath
TYK2 JAK1 27898060 7504784 7589562 8702790 N/A N/A OmniPath
TYK2 STAT2 12040185 1638633 27898060 8605877 stimulant N/A OmniPath
GHR TYK2 10502458 27898060 stimulant N/A OmniPath
IFNB1 TYK2 10542297 27898060 stimulant N/A OmniPath
PTPN11 TYK2 27898060 9794795 N/A N/A OmniPath
IL10RB TYK2 10347215 27898060 stimulant N/A OmniPath
TYK2 STAT3 10542297 27898060 stimulant N/A OmniPath
CAMK2A TYK2 15659558 27898060 N/A N/A OmniPath
TYK2 STAT5B 27898060 9872990 stimulant N/A OmniPath
TYK2 STAT4 16324152 27898060 inhibition,stimulant N/A OmniPath
MPL TYK2 27898060 7543416 stimulant N/A OmniPath
PTAFR TYK2 11309383 14500680 27898060 N/A N/A OmniPath
IL20RA TYK2 12941475 27898060 stimulant N/A OmniPath
VAV1 TYK2 10673353 27898060 9038355 N/A N/A OmniPath
TYK2 VAV1 10673353 27898060 9038355 N/A N/A OmniPath
IL23R TYK2 12023369 27898060 stimulant N/A OmniPath
IL20RB TYK2 12941475 27898060 stimulant N/A OmniPath
TYK2 IL13RA1 10409622 12223527 27898060 8609418 N/A N/A OmniPath
IL13RA1 TYK2 10409622 12223527 12704343 27898060 8609418 stimulant N/A OmniPath
IL22RA1 TYK2 12087100 12941475 27898060 stimulant N/A OmniPath
PTPRC TYK2 11201744 27898060 N/A N/A OmniPath
IFNAR2 TYK2 12040185 1296032 12960323 27898060 stimulant N/A OmniPath
TYK2 DUSP3 17785772 27898060 stimulant N/A OmniPath
IFNLR1 TYK2 15120645 27898060 stimulant N/A OmniPath

Visualization










  Return