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GENE：STAT2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STAT2
FullNmae signal transducer and activator of transcription 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11363
EnsembleID ENSG00000170581
Uniprot P52630

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STAT2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STAT2 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
STAT2 GO:0000785,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0000981,GO:0001932,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0005886,GO:0006357,GO:0006357,GO:0006952,GO:0007259,GO:0007259,GO:0007259,GO:0042127,GO:0042802,GO:0043434,GO:0044389,GO:0045944,GO:0045944,GO:0051607,GO:0060337,GO:0060337,GO:0060339,GO:0070721,GO:0090140,GO:0090575

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
STAT2 hsa:6773 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04217 Necroptosis - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
STAT2 hsa:6773 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05160 Hepatitis C - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05161 Hepatitis B - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05162 Measles - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05164 Influenza A - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
STAT2 hsa:6773 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT1 STAT2 10022928 10982844 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17351669 17513775 17559085 17689680 18272812 18508557 19833085 21263073 21930765 24243840 25960930 26192618 29145629 8232552 8621447 8683106 interaction type,physical association inferred by curator ACSN,Reactome
STAT2 PDCD1 11134049 11830590 12193701 12223527 12796776 12811837 12967644 14607900 14764699 15814715 17016554 17513775 17559085 17689680 18272812 19833085 21263073 21930765 25960930 26192618 8683106 interaction type N/A ACSN
IRF7 STAT2 10924517 12077266 14578356 18028425 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT2 STAT6 10490982 21268015 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 STAT1 10490982 10523853 10925286 12954221 14722125 15978943 17374731 17923090 20943654 21178011 21268015 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IFNAR1 STAT2 10022928 10542297 10582086 10982844 11694501 12220192 15312780 15449939 16171819 16987978 17351669 17969444 18508557 23180781 23331499 24243840 29145629 7526154 8197134 8232552 8605876 8621447 8702790 8943354 9334213 interaction type,physical association affinity chromatography technology,gst pull down,inferred by curator InnateDB,Reactome,SignaLink,SignaLink
IFNAR2 STAT2 10582086 11786546 12220192 18456457 18988627 23180781 23331499 9121453 interaction type,physical association anti tag coimmunoprecipitation,gst pull down,pull down,surface plasmon resonance InnateDB,SignaLink,SignaLink
IRF9 STAT2 21268015 23180781 9242679 physical association anti tag coimmunoprecipitation InnateDB
STAT2 IRF9 10925286 12590259 12954221 15668228 15978943 16195385 17351669 17923090 20943654 21178011 21903422 23180781 23331499 29145629 7537377 8621447 8943351 9242679 stimulation,physical association anti tag coimmunoprecipitation,inferred by curator,electrophoretic mobility supershift assay InnateDB,Reactome,SignaLink
KPNA1 STAT2 12740372 23180781 physical association gst pull down InnateDB
STAT2 EIF2AK2 12954221 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT2 HDAC1 14645718 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
STAT2 IFIT2 12509459 14600148 15194680 16497831 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 CCL19 17182562 23180781 physical association affinity chromatography technology InnateDB
STAT2 IFI6 12244326 15668228 16195385 17923090 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF5 STAT2 15805103 23180781 physical association anti tag coimmunoprecipitation InnateDB
CCL2 STAT2 17167270 23180781 physical association electrophoretic mobility supershift assay InnateDB
STAT2 BRCA1 17374731 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 OAS1 15668228 23180781 physical association electrophoretic mobility supershift assay InnateDB
STAT2 IRF1 15668228 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 MED14 12509459 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 STAT2 18678383 23180781 physical association pull down InnateDB
STAT2 GBP1 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFI27 STAT2 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFITM1 STAT2 12244326 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 IFIT1 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFITM3 STAT2 16195385 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 ISG15 10523853 10925286 20943654 23180781 physical association electrophoretic mobility supershift assay InnateDB
CXCL11 STAT2 17202361 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 ZC3HAV1 20048147 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL21 STAT2 15178704 23180781 physical association anti tag coimmunoprecipitation InnateDB
EIF2AK2 STAT2 21178011 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT2 ADAR 23180781 26335850 physical association anti tag coimmunoprecipitation InnateDB
TYK2 STAT2 10022928 10542297 10982844 11694501 12040185 15312780 15449939 16171819 16987978 17351669 17969444 18508557 18988627 23331499 24243840 29145629 7526154 8197134 8232552 8605876 8605877 8621447 8702790 8943354 9334213 stimulation,physical association inferred by curator Reactome,SignaLink,SignaLink
STAT2 STAT2 10022928 10542297 10982844 16987978 18508557 29145629 8197134 8232552 8605876 physical association inferred by curator Reactome
JAK1 STAT2 10022928 10542297 10982844 12040185 16987978 18508557 18988627 23331499 24243840 29145629 8197134 8232552 8605876 9020188 stimulation,physical association inferred by curator Reactome,SignaLink,SignaLink
PTPN6 STAT2 18508557 29145629 8943354 dephosphorylation reaction inferred by curator Reactome
PTPN1 STAT2 11694501 29145629 dephosphorylation reaction inferred by curator Reactome
JAK3 STAT2 11406370 12495636 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR STAT2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 STAT2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 STAT2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 STAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 STAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS STAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BRCA1 STAT2 17374731 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 STAT2 16918696 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 STAT2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001F0C23 STAT2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 STAT2 23706177 25074381 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000047A67D STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 STAT2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS00004A9320 STAT2 23706177 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C85B2 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000B989F STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001A7F58 STAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LCK STAT2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SMARCE1 STAT2 25348397 N/A physical interaction ComPPI
SMARCC1 STAT2 25348397 N/A physical interaction ComPPI
STAT1 STAT2 10446176 14525934 15825084 17923090 24065129 24234451 25348397 26966684 8605877 8621447 association,physical association anti bait coimmunoprecipitation,coimmunoprecipitation,cross-linking study,experimental interaction detection,pull down,physical interaction,competition binding,in vivo ComPPI,HPRD,IntAct
TYK2 STAT2 14525934 25348397 8605877 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
KEAP1 STAT2 25348397 N/A physical interaction ComPPI
HSP90AB1 STAT2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CREBBP STAT2 10464260 14525934 25348397 8848048 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EP300 STAT2 25348397 N/A physical interaction ComPPI
INPPL1 STAT2 25348397 N/A physical interaction ComPPI
IFNAR1 STAT2 11786546 12220192 14525934 24234451 25348397 7559568 8605876 9121453 9677371 association anti bait coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HSP90AA1 STAT2 25348397 N/A physical interaction ComPPI
STAT2 MED14 12509459 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STAT2 SMARCA4 12244326 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
STAT2 JAK2 14525934 25348397 7746328 N/A experimental interaction detection,in vivo ComPPI,HPRD
STAT2 CXCR4 10506573 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STAT2 STAT6 10490982 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STAT2 IRF9 14525934 17923090 21903422 24065129 24234451 25348397 9242679 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
STAT2 JAK1 14525934 25348397 9020188 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STAT2 SMARCC2 25348397 N/A physical interaction ComPPI
STAT2 IFNAR2 11786546 14525934 17923090 24234451 25348397 9121453 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
STAT2 HSPB1 25348397 N/A physical interaction ComPPI
STAT2 RCAN1 25348397 N/A physical interaction ComPPI
STAT2 ELAVL1 25348397 N/A physical interaction ComPPI
STAT2 HSP90AA2P 25348397 N/A physical interaction ComPPI
STAT2 FNTA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STAT2 GAA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STAT2 IWS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STAT2 UBR4 25348397 N/A physical interaction ComPPI
STAT2 EGFR 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
STAT2 LIPT1 25348397 N/A physical interaction ComPPI
STAT2 DOK4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
STAT2 XPO1 25348397 N/A physical interaction ComPPI
STAT2 PML 25348397 N/A physical interaction ComPPI
STAT2 AURKA 25348397 N/A physical interaction ComPPI
STAT2 CDH1 25348397 N/A physical interaction ComPPI
STAT2 ZNF692 25348397 N/A physical interaction ComPPI
STAT2 TACC1 25348397 N/A physical interaction ComPPI
STAT2 MYCBP2 25348397 N/A physical interaction ComPPI
STAT2 DPP9 25348397 N/A physical interaction ComPPI
STAT2 INSYN2A 25348397 N/A physical interaction ComPPI
STAT2 FBXO45 25348397 N/A physical interaction ComPPI
STAT2 TRRAP 25348397 N/A physical interaction ComPPI
STAT2 USP1 25348397 N/A physical interaction ComPPI
STAT2 SELENOO 25348397 N/A physical interaction ComPPI
STAT2 KLHL10 25348397 N/A physical interaction ComPPI
STAT2 FBXO11 25348397 N/A physical interaction ComPPI
STAT2 EP400 25348397 N/A physical interaction ComPPI
STAT2 IARS2 25348397 N/A physical interaction ComPPI
STAT2 GYPA 25348397 N/A physical interaction ComPPI
STAT2 STAT3 17923090 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
STAT2 DCST1 24234451 25348397 27782195 physical association anti bait coimmunoprecipitation ComPPI,IntAct
STAT2 HDAC1 14525934 14645718 N/A experimental interaction detection HPRD
STAT2 STAT2 24234451 8605877 association coimmunoprecipitation,pull down,competition binding IntAct
FGFR1 STAT2 27898060 7532278 N/A N/A OmniPath
STAT6 STAT2 10490982 21268015 27898060 N/A N/A OmniPath
MED14 STAT2 12509459 27898060 stimulant N/A OmniPath
STAT2 MED14 12509459 27898060 N/A N/A OmniPath
STAT1 STAT2 10446176 10490982 12048190 14722125 1502203 15825084 15978943 17923090 21178011 21268015 27898060 8605877 8621447 9724754 N/A N/A OmniPath
STAT2 STAT1 10446176 10490982 12048190 14722125 1502203 15825084 15978943 17923090 21178011 21268015 27898060 8605877 8621447 9724754 stimulant N/A OmniPath
IFNAR1 STAT2 11786546 12220192 15356134 27898060 7559568 8605876 9121453 9677371 N/A N/A OmniPath
STAT2 IFNAR1 11786546 12220192 15356134 27898060 7559568 8605876 9121453 9677371 N/A N/A OmniPath
JAK1 STAT2 12040185 27898060 9020188 stimulant N/A OmniPath
TYK2 STAT2 12040185 1638633 27898060 8605877 stimulant N/A OmniPath
CREBBP STAT2 10464260 17923090 27898060 8848048 stimulant N/A OmniPath
HDAC1 STAT2 14645718 27898060 N/A N/A OmniPath
STAT2 EP300 10464260 15154850 18678383 27898060 N/A N/A OmniPath
STAT2 IRF9 12590259 15978943 17923090 21178011 21268015 21903422 27898060 8943351 9242679 stimulant N/A OmniPath
IRF9 STAT2 12590259 15978943 17923090 21178011 21268015 21903422 27898060 8943351 9242679 stimulant N/A OmniPath
IFNAR2 STAT2 11786546 12220192 17923090 18456457 27898060 9121453 stimulant N/A OmniPath
STAT2 IFNAR2 11786546 12220192 17923090 18456457 27898060 9121453 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BB70F STAT2 27087310 direct interaction,inhibition N/A NPInter

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