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GENE：STAT4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STAT4
FullNmae signal transducer and activator of transcription 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11365
EnsembleID ENSG00000138378
Uniprot Q14765

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STAT4 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STAT4 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
STAT4 GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005829,GO:0006357,GO:0006952,GO:0007259,GO:0007259,GO:0019221,GO:0035722,GO:0042127,GO:0042802,GO:0043434,GO:0045063,GO:0045944,GO:0090575,GO:0090575

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
STAT4 hsa:6775 path:hsa04217 Necroptosis - Homo sapiens (human)
STAT4 hsa:6775 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
STAT4 hsa:6775 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
STAT4 hsa:6775 path:hsa05161 Hepatitis B - Homo sapiens (human)
STAT4 hsa:6775 path:hsa05200 Pathways in cancer - Homo sapiens (human)
STAT4 hsa:6775 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT4 PRF1 10807786 10961885 11449378 12372421 26192618 8683106 8700208 9715265 interaction type N/A ACSN
STAT4 IFNG 10807786 10961885 11449378 12372421 26192618 8683106 8700208 9715265 interaction type N/A ACSN
IL12RB1 STAT4 10415122 10582086 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 23331499 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN,SignaLink
IL12RB2 STAT4 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type N/A ACSN
JAK2 STAT4 10807786 11867689 12244147 12372421 14610620 15546391 16324152 19833085 20406969 21042762 21115385 22077060 23331499 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type,stimulation N/A ACSN,SignaLink
TYK2 STAT4 10807786 11867689 12244147 12372421 14610620 15546391 16324152 19833085 20406969 21042762 21115385 22077060 23331499 24091328 24204259 26192618 27216177 7543512 8683106 8700208 9834059 interaction type,stimulation N/A ACSN,SignaLink
IL15 STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL15RA STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL2RB STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21516110 21840487 23124025 23180781 24829413 25582338 26192618 7512720 7521688 7523571 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
IL2RG STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
JAK1 STAT4 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 26192618 7512720 7521688 7523571 interaction type N/A ACSN
IL2 STAT4 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26192618 26755705 2965306 6164929 9625766 interaction type N/A ACSN
IFNG STAT4 11449378 15522880 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT3 STAT4 15522880 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF4 STAT4 14581002 16272311 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL2RA STAT4 12244150 23180781 physical association electrophoretic mobility shift assay InnateDB
IRF1 STAT4 10358173 21516110 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
STAT4 IL12RB2 10415122 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL21 STAT4 15178704 23180781 physical association anti tag coimmunoprecipitation InnateDB
TBX21 STAT4 21516110 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
GATA3 STAT4 23180781 23232398 physical association anti tag coimmunoprecipitation InnateDB
PIAS2 STAT4 12716907 23331499 stimulation N/A SignaLink
SOCS3 STAT4 14559241 23331499 stimulation N/A SignaLink
MAPK14 STAT4 10961885 17502367 23331499 stimulation N/A SignaLink
CNTFR STAT4 10582086 23331499 stimulation N/A SignaLink
LEPR STAT4 10582086 23331499 stimulation N/A SignaLink
IL23R STAT4 10582086 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR STAT4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 STAT4 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 STAT4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 STAT4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 STAT4 21632975 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXA1 STAT4 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 STAT4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 STAT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF STAT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A STAT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 STAT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 STAT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 STAT4 17046972 trascriptional regulation,stimulation inferred by curator TFlink
RELA STAT4 17046972 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 STAT4 24732377 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
STAT4 IFNGR1 25361965 interaction type N/A PTMCode2
IFNGR1 STAT4 25361965 interaction type N/A PTMCode2
STAT4 JUN 25361965 interaction type N/A PTMCode2
JUN STAT4 25361965 interaction type N/A PTMCode2
IL12RB2 STAT4 25361965 interaction type N/A PTMCode2
STAT4 IL12RB2 25361965 interaction type N/A PTMCode2
STAT3 STAT4 25361965 interaction type N/A PTMCode2
STAT4 STAT3 25361965 interaction type N/A PTMCode2
MAPK14 STAT4 25361965 interaction type N/A PTMCode2
STAT4 MAPK14 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NMI STAT4 14525934 24234451 25348397 9989503 physical association experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
PIAS2 STAT4 12716907 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
STAT1 STAT4 25348397 N/A physical interaction ComPPI
CRK STAT4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
JUN STAT4 11801649 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CREBBP STAT4 14525934 14660657 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STAT4 MAPK14 10961885 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STAT4 MAP2K6 10961885 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
STAT4 IL12RB1 10415122 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
STAT4 IL12RB2 10415122 14525934 24234451 25348397 9890938 association experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
STAT4 ZNF467 12426389 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STAT4 STAT3 14525934 15522880 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
STAT4 TRIM28 25348397 N/A physical interaction ComPPI
STAT4 ADRB2 25348397 N/A physical interaction ComPPI
STAT4 TKT 25348397 N/A physical interaction ComPPI
STAT4 SH2D1B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
STAT4 PDLIM2 25348397 N/A physical interaction ComPPI
STAT4 LAMTOR5 22740693 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
STAT4 STAT4 14525934 14704793 18591661 24234451 N/A cosedimentation in solution,experimental interaction detection,molecular sieving,two hybrid HPRD,IntAct
SOCS3 STAT4 14559241 27898060 stimulant N/A OmniPath
LEPR STAT4 10582086 27898060 stimulant N/A OmniPath
TYK2 STAT4 16324152 27898060 inhibition,stimulant N/A OmniPath
MAPK14 STAT4 10961885 17502367 1750237 27898060 stimulant N/A OmniPath
MAP2K6 STAT4 10961885 27898060 N/A N/A OmniPath
CSNK2A1 STAT4 10961885 27898060 N/A N/A OmniPath
STAT4 STAT3 15522880 27898060 N/A N/A OmniPath
JAK2 STAT4 16324152 27898060 inhibition,stimulant N/A OmniPath
IL12RB1 STAT4 10415122 1058209 27898060 inhibition,stimulant N/A OmniPath
IL23R STAT4 10582086 27898060 stimulant N/A OmniPath
STAT4 IL12RB2 10415122 27898060 9890938 N/A N/A OmniPath
IL12RB2 STAT4 10415122 27898060 9890938 inhibition,stimulant N/A OmniPath
PIAS2 STAT4 12716907 27898060 inhibition,stimulant N/A OmniPath
STAT4 LAMTOR5 22740693 27898060 stimulant N/A OmniPath

Visualization










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