GENE：CHMP2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP2A |
| FullNmae | charged multivesicular body protein 2A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:30216 |
| EnsembleID | ENSG00000130724 |
| Uniprot | O43633 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP2A | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2A | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP2A | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2A | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP2A | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2A | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP2A | GO:0000421,GO:0000776,GO:0000785,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005635,GO:0005643,GO:0005765,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006914,GO:0006997,GO:0007080,GO:0010324,GO:0010458,GO:0010824,GO:0015031,GO:0016020,GO:0016236,GO:0019076,GO:0019076,GO:0019904,GO:0030117,GO:0030496,GO:0031210,GO:0031468,GO:0032509,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0039702,GO:0039702,GO:0039702,GO:0043162,GO:0045184,GO:0045324,GO:0046761,GO:0046761,GO:0051258,GO:0051260,GO:0051469,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0090148,GO:0097352,GO:1901673,GO:1902774,GO:1903543,GO:1903723,GO:1904903,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP2A | hsa:27243 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP2A | hsa:27243 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CHMP2A | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | CHMP2A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| E2F1 | CHMP2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CHMP2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | CHMP2A | N/A | rna interference,inhibition | experimental interaction detection | miRSponge |
| URS0000324096 | CHMP2A | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
| URS00003D5391 | CHMP2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000039A052 | CHMP2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000003FD55 | CHMP2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000021D7C8 | CHMP2A | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CHMP2A | VPS4B | 14525934 15173323 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| CHMP2A | VPS4A | 14505570 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2A | NOL4 | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2A | EIF2B5 | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2A | MITD1 | 14525934 16730941 24234451 25348397 | colocalization,physical association | anti tag coimmunoprecipitation,beta lactamase complementation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,confocal microscopy,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2A | CHMP3 | 14525934 16730941 23051622 24234451 25348397 | protein cleavage,physical association | two hybrid,transmission electron microscopy,pull down,surface plasmon resonance,physical interaction,enzymatic footprinting,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2A | STAMBP | 16730941 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| CHMP2A | VTA1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | USP8 | 19302785 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| CHMP2A | USP54 | 19302785 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| CHMP2A | RANBP2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | ERLIN1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | PPP1CA | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | RRBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | ITGA4 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | E2F4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CHMP2A | TGFB3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| CHMP2A | DOCK8 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | UFD1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | CHMP4B | 23051622 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,surface plasmon resonance,physical interaction | ComPPI,IntAct |
| CHMP2A | CDV3 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | CSTF2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | HNRNPA3 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | EIF4EBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | PARVA | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | XPO1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | RAB2A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | RAB5C | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | RAB7A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | ATP6AP2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | TFG | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2A | TRIM35 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | DECR1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | CHMP5 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | SIX2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | SPAST | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | SNAP23 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | CCDC83 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | OSTF1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | DLST | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| CHMP2A | TARDBP | 25348397 | N/A | physical interaction | ComPPI |
| CHMP2A | PCBD1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| CHMP2A | VCAM1 | 22623428 24234451 25348397 | association | cross-linking study | ComPPI,IntAct |
| CHMP2A | RAB11A | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP2A | TNPO3 | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP2A | TRPC4AP | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP2A | TTC19 | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP2A | CHMP2A | 14525934 16730941 24234451 | physical association | two hybrid,two hybrid | HPRD,IntAct |
| HNRNPDL | CHMP2A | 24234451 30021884 | physical association | cross-linking study | IntAct |