GENE：CHMP2B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP2B |
| FullNmae | charged multivesicular body protein 2B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:24537 |
| EnsembleID | ENSG00000083937 |
| Uniprot | Q9UQN3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP2B | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2B | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP2B | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2B | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP2B | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP2B | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP2B | GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005643,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005770,GO:0005771,GO:0005828,GO:0005829,GO:0005829,GO:0005886,GO:0006914,GO:0006914,GO:0006997,GO:0007032,GO:0007080,GO:0010824,GO:0014069,GO:0015031,GO:0016236,GO:0019076,GO:0019076,GO:0019904,GO:0030496,GO:0031468,GO:0032509,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0039702,GO:0039702,GO:0039702,GO:0043162,GO:0045296,GO:0045324,GO:0046761,GO:0050804,GO:0050890,GO:0051469,GO:0061763,GO:0061763,GO:0061952,GO:0070050,GO:0070062,GO:0071985,GO:0090148,GO:0097352,GO:0098978,GO:0099159,GO:0099175,GO:1901673,GO:1902774,GO:1904903,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP2B | hsa:25978 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP2B | hsa:25978 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| CHMP2B | hsa:25978 | path:hsa05014 | Amyotrophic lateral sclerosis - Homo sapiens (human) |
| CHMP2B | hsa:25978 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CHMP2B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CHMP2B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000018C928 | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D69F6 | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077AED | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | CHMP2B | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BCD9C | CHMP2B | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000098B3B | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000080D0A | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000058276F | CHMP2B | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CHMP2A | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| DPY30 | CHMP2B | 14525934 16730941 24234451 25348397 | physical association | two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| VPS4B | CHMP2B | 25348397 | N/A | nuclear magnetic resonance,physical interaction,surface plasmon resonance array | ComPPI |
| PNMA1 | CHMP2B | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP3 | CHMP2B | 14525934 16730941 23051622 24234451 25348397 | physical association | two hybrid,surface plasmon resonance,physical interaction,surface plasmon resonance array,two hybrid | ComPPI,HPRD,IntAct |
| RAB7A | CHMP2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CDH1 | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| SQSTM1 | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| ATP6AP2 | CHMP2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PAFAH1B1 | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| TRAF2 | CHMP2B | 14525934 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| VHL | CHMP2B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NR4A1 | CHMP2B | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| USP8 | CHMP2B | 19302785 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| ATP6V1B1 | CHMP2B | 25348397 | N/A | physical interaction | ComPPI |
| CENPF | CHMP2B | 14525934 16730941 24234451 25348397 | physical association | two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| MAD2L1 | CHMP2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| VPS4A | CHMP2B | 25348397 | N/A | physical interaction,surface plasmon resonance array | ComPPI |
| TERF2IP | CHMP2B | 21044950 24234451 25348397 | physical association | pull down,physical interaction,bimolecular fluorescence complementation | ComPPI,IntAct |
| ATP6V1A | CHMP2B | 21674799 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RAB5C | CHMP2B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| USP54 | CHMP2B | 19302785 24234451 25348397 | N/A | pull down,physical interaction | ComPPI,IntAct |
| CHMP4B | CHMP2B | 23051622 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,surface plasmon resonance,physical interaction | ComPPI,IntAct |
| ATP5F1C | CHMP2B | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2B | PHGDH | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2B | LTN1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2B | GOLT1B | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2B | MYH14 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2B | SGO1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP2B | TMEM106B | 25348397 | N/A | physical interaction | ComPPI |
| MALSU1 | CHMP2B | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP2B | CHMP2B | 14525934 16730941 24234451 | physical association | two hybrid,two hybrid | HPRD,IntAct |
| CHMP2B | ATP5ME | 24234451 30021884 | physical association | cross-linking study | IntAct |