GENE：CHMP4A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP4A |
| FullNmae | charged multivesicular body protein 4A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:20274 |
| EnsembleID | ENSG00000254505 |
| Uniprot | Q9BY43 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP4A | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4A | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP4A | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4A | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP4A | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4A | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP4A | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP4A | GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005634,GO:0005643,GO:0005737,GO:0005765,GO:0005768,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006620,GO:0006900,GO:0006900,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0008289,GO:0009898,GO:0009898,GO:0010324,GO:0016236,GO:0030117,GO:0030496,GO:0031468,GO:0032511,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0039702,GO:0039702,GO:0042802,GO:0042803,GO:0043162,GO:0046761,GO:0050877,GO:0051117,GO:0051258,GO:0051469,GO:0061763,GO:0061952,GO:0071985,GO:0071985,GO:0090148,GO:0097320,GO:0097320,GO:0097352,GO:1901673,GO:1902774,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP4A | hsa:29082 | path:hsa03250 | Viral life cycle - HIV-1 - Homo sapiens (human) |
| CHMP4A | hsa:29082 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP4A | hsa:29082 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CHMP4A | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VPS4B | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| CDCA3 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| SYT17 | CHMP4A | 14525934 16189514 16730941 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid | ComPPI,HPRD,IntAct |
| CHRAC1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| NFYA | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| CHMP3 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| F2R | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| EIF6 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| RANBP1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| SMARCB1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| EGFR | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| TTC19 | CHMP4A | 16730941 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| PPIA | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| HSPE1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| TFG | CHMP4A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TNPO3 | CHMP4A | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| GAK | CHMP4A | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PDCD6IP | CHMP4A | 12860994 14525934 14583093 14678797 17350572 18511562 24234451 25348397 | N/A | experimental interaction detection,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| STAMBP | CHMP4A | 16730941 17711858 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| VPS4A | CHMP4A | 12860994 14525934 16730941 24234451 25348397 | physical association | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| TALDO1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| RCN1 | CHMP4A | 25348397 | N/A | physical interaction | ComPPI |
| USP54 | CHMP4A | 19302785 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| CHMP4A | CHMP4C | 14505570 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| CHMP4A | CHMP6 | 14505570 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| CHMP4A | CDK13 | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4A | CC2D1A | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4A | CHMP5 | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4A | CHMP4B | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP4A | ADSS2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | DCK | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | EFHD2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | IDH1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | RBBP7 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | ARL6IP6 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | VAX2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP4A | COX15 | 24234451 25348397 29128334 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| CHMP4A | BROX | 22484091 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP4A | ETS1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| CHMP4A | CHMP7 | 16856878 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| CHMP4A | CHMP4A | 14525934 16730941 24234451 | physical association | two hybrid,two hybrid | HPRD,IntAct |