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GENE：CHMP4B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CHMP4B
FullNmae charged multivesicular body protein 4B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16171
EnsembleID ENSG00000101421
Uniprot Q9H444

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CHMP4B pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP4B pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHMP4B necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP4B necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHMP4B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP4B autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP4B autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHMP4B cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
CHMP4B GO:0000281,GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005737,GO:0005765,GO:0005768,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006620,GO:0006900,GO:0006914,GO:0006914,GO:0006997,GO:0007080,GO:0009898,GO:0009898,GO:0010458,GO:0010506,GO:0010824,GO:0016236,GO:0030117,GO:0030496,GO:0031468,GO:0031982,GO:0032511,GO:0032585,GO:0036258,GO:0036258,GO:0036438,GO:0039702,GO:0039702,GO:0039702,GO:0042802,GO:0042803,GO:0043162,GO:0045296,GO:0046755,GO:0046761,GO:0046761,GO:0050877,GO:0051258,GO:0051469,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0071985,GO:0090148,GO:0090148,GO:0090611,GO:0097352,GO:1901673,GO:1902774,GO:1904930

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CHMP4B hsa:128866 path:hsa03250 Viral life cycle - HIV-1 - Homo sapiens (human)
CHMP4B hsa:128866 path:hsa04144 Endocytosis - Homo sapiens (human)
CHMP4B hsa:128866 path:hsa04217 Necroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 CHMP4B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CHMP4B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CHMP4B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000007FBA CHMP4B 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000171CD1 CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000001EB3 CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F0F49 CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 CHMP4B 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIAS2 CHMP4B 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
UBE2I CHMP4B 14525934 16189514 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DAXX CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP2A CHMP4B 23051622 24234451 25348397 26496610 association anti tag coimmunoprecipitation,surface plasmon resonance,physical interaction ComPPI,IntAct
IMPDH2 CHMP4B 25348397 N/A physical interaction ComPPI
VCP CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LMNA CHMP4B 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
H2BC4 CHMP4B 25348397 N/A physical interaction ComPPI
AIM2 CHMP4B 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
NF2 CHMP4B 25348397 N/A physical interaction ComPPI
TAF1 CHMP4B 25348397 N/A physical interaction ComPPI
FLNA CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKAR1A CHMP4B 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RAB7A CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MVP CHMP4B 25348397 N/A physical interaction ComPPI
CANX CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDH1 CHMP4B 25348397 N/A physical interaction ComPPI
EIF2AK2 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NECTIN3 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF6 CHMP4B 25348397 N/A physical interaction ComPPI
VDAC1 CHMP4B 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NUP98 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLTC CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BIN1 CHMP4B 25348397 N/A physical interaction ComPPI
HTT CHMP4B 17500595 24234451 25348397 physical association two hybrid ComPPI,IntAct
FBXO5 CHMP4B 25348397 N/A physical interaction ComPPI
EVI5 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOLC1 CHMP4B 25348397 N/A physical interaction ComPPI
HIPK2 CHMP4B 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMC3 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP8 CHMP4B 19302785 24234451 25348397 N/A pull down ComPPI,IntAct
VCAM1 CHMP4B 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 CHMP4B 25348397 N/A physical interaction ComPPI
ELOC CHMP4B 25348397 N/A physical interaction ComPPI
MECP2 CHMP4B 25348397 N/A physical interaction ComPPI
PLIN3 CHMP4B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFG CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UGCG CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6IP CHMP4B 12860994 14525934 14678797 18434552 18511562 21889351 22484091 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
KPNA6 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAMBP CHMP4B 14525934 16730941 17711858 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
RPL6 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EXOSC9 CHMP4B 16730941 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EEF1G CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5C CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CTCF CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TLN2 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4A CHMP4B 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP4B CHMP4C 14505570 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP4B CHMP5 14525934 16730941 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP4B TP53 25348397 N/A physical interaction ComPPI
CHMP4B CHMP2B 23051622 24234451 25348397 26496610 association anti tag coimmunoprecipitation,surface plasmon resonance,physical interaction ComPPI,IntAct
CHMP4B H2BC11 25348397 N/A physical interaction ComPPI
CHMP4B ATP6V0A1 25348397 N/A physical interaction ComPPI
CHMP4B FLOT2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B IGF2R 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B IST1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B ZNF281 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B SLC38A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B NLE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B CC2D1A 16730941 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
CHMP4B CDK5RAP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B OSBPL9 25348397 N/A physical interaction ComPPI
CHMP4B CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP4B PCGF1 25348397 N/A physical interaction ComPPI
CHMP4B DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
CHMP4B CHMP7 16856878 24234451 25348397 colocalization,physical association two hybrid,pull down,confocal microscopy ComPPI,IntAct
CHMP4B PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
ATP6V1B2 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct

Visualization










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