GENE：CHMP6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CHMP6 |
| FullNmae | charged multivesicular body protein 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25675 |
| EnsembleID | ENSG00000176108 |
| Uniprot | Q96FZ7 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CHMP6 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP6 | pyroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP6 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP6 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CHMP6 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP6 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CHMP6 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CHMP6 | GO:0000421,GO:0000776,GO:0000815,GO:0000815,GO:0000815,GO:0001778,GO:0005515,GO:0005643,GO:0005765,GO:0005771,GO:0005828,GO:0005829,GO:0005886,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0007175,GO:0010008,GO:0015031,GO:0016020,GO:0016236,GO:0030496,GO:0031468,GO:0032511,GO:0032585,GO:0036258,GO:0036258,GO:0039702,GO:0042176,GO:0043162,GO:0044877,GO:0046761,GO:0051469,GO:0061763,GO:0061952,GO:0070062,GO:0071985,GO:0090148,GO:0097352,GO:1901673,GO:1902774,GO:1904902,GO:1904930 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CHMP6 | hsa:79643 | path:hsa03250 | Viral life cycle - HIV-1 - Homo sapiens (human) |
| CHMP6 | hsa:79643 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| CHMP6 | hsa:79643 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CHMP6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CHMP6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | CHMP6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CHMP6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| USP8 | CHMP6 | 19302785 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| TRPC4AP | CHMP6 | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| BAIAP2 | CHMP6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CHMP4A | CHMP6 | 14505570 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| CHMP6 | ELOF1 | 14525934 16730941 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| CHMP6 | RIPPLY1 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP6 | SUN2 | 25348397 | N/A | physical interaction | ComPPI |
| CHMP6 | CDK13 | 16730941 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |