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GENE：CHMP5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CHMP5
FullNmae charged multivesicular body protein 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:26942
EnsembleID ENSG00000086065
Uniprot Q9NZZ3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CHMP5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP5 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CHMP5 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP5 lysosomal_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CHMP5 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CHMP5 GO:0000421,GO:0000776,GO:0001778,GO:0001919,GO:0005515,GO:0005643,GO:0005765,GO:0005771,GO:0005828,GO:0005829,GO:0005829,GO:0005886,GO:0006900,GO:0006914,GO:0006997,GO:0007080,GO:0010824,GO:0015031,GO:0030496,GO:0031468,GO:0032511,GO:0032585,GO:0036258,GO:0039702,GO:0043162,GO:0045296,GO:0046755,GO:0046761,GO:0051469,GO:0061763,GO:0061952,GO:0070062,GO:0071222,GO:0071225,GO:0071985,GO:0071985,GO:0090148,GO:0097352,GO:1901673,GO:1902774,GO:1904903,GO:1904930

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CHMP5 hsa:51510 path:hsa04144 Endocytosis - Homo sapiens (human)
CHMP5 hsa:51510 path:hsa04217 Necroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ISG15 CHMP5 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
AR CHMP5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CHMP5 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 CHMP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CHMP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CHMP5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PIAS2 CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2I CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
CHMP2A CHMP5 25348397 N/A physical interaction ComPPI
VPS4B CHMP5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MITD1 CHMP5 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SH3KBP1 CHMP5 25348397 N/A physical interaction ComPPI
SGTB CHMP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ISG15 CHMP5 25348397 N/A physical interaction ComPPI
H2BC4 CHMP5 25348397 N/A physical interaction ComPPI
PDCD10 CHMP5 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
APPBP2 CHMP5 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CHMP3 CHMP5 25348397 N/A physical interaction ComPPI
RAB7A CHMP5 25348397 N/A physical interaction ComPPI
CDH1 CHMP5 25348397 N/A physical interaction ComPPI
BAG6 CHMP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCA4 CHMP5 16730941 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PXN CHMP5 25348397 N/A physical interaction ComPPI
HNRNPL CHMP5 25348397 N/A physical interaction ComPPI
HABP4 CHMP5 25348397 N/A physical interaction ComPPI
EWSR1 CHMP5 25348397 N/A physical interaction ComPPI
RAB5A CHMP5 25348397 N/A physical interaction ComPPI
UBA2 CHMP5 25348397 N/A physical interaction ComPPI
USP8 CHMP5 19302785 24234451 25348397 N/A pull down ComPPI,IntAct
TSG101 CHMP5 25348397 N/A physical interaction ComPPI
AURKA CHMP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRPC4AP CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
ATP6V1B1 CHMP5 25348397 N/A physical interaction ComPPI
TTC19 CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
SNCA CHMP5 25348397 N/A physical interaction ComPPI
SNRPD2 CHMP5 25348397 N/A physical interaction ComPPI
TFG CHMP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GTF3A CHMP5 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HNRNPD CHMP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BRCA1 CHMP5 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
STAMBP CHMP5 17711858 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
VPS4A CHMP5 25348397 N/A physical interaction ComPPI
PSMA4 CHMP5 25348397 N/A physical interaction ComPPI
EXOSC9 CHMP5 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
ATP6V1A CHMP5 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
USP54 CHMP5 19302785 24234451 25348397 N/A pull down ComPPI,IntAct
CHMP4A CHMP5 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP4B CHMP5 14525934 16730941 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TCP10L CHMP5 25348397 N/A physical interaction ComPPI
CHMP1B CHMP5 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
VTA1 CHMP5 16730941 17261583 21543490 24234451 25348397 27898060 physical association two hybrid,physical interaction ComPPI,IntAct,OmniPath
CHMP5 ZNF91 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP5 ZNF142 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP5 URGCP 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP5 RPL38 14525934 16730941 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CHMP5 CAMK2A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CHMP5 UNK 25348397 N/A physical interaction ComPPI
CHMP5 ACTR6 25348397 N/A physical interaction ComPPI
CHMP5 H2BC11 25348397 N/A physical interaction ComPPI
CHMP5 STMN4 25348397 N/A physical interaction ComPPI
CHMP5 CHMP1A 25348397 N/A physical interaction ComPPI
CHMP5 BROX 25348397 N/A anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,x-ray crystallography,physical interaction ComPPI
CHMP5 CDK13 16730941 24234451 25348397 physical association two hybrid ComPPI,IntAct
CHMP5 CHMP5 14525934 16730941 24234451 physical association two hybrid,two hybrid HPRD,IntAct
ISG15 CHMP5 16009940 20164219 27898060 N/A N/A OmniPath

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