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GENE：NLRP3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NLRP3
FullNmae NLR family pyrin domain containing 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16400
EnsembleID ENSG00000162711
Uniprot Q96P20

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NLRP3 pyroptosis 39672029 This study investigates the role of the Chemokine receptor 2 (CCR2) in regulating NLRP3-dependent cardiomyocyte pyroptosis following myocardial ischemia-reperfusion (MIR), elucidating its molecular mechanisms. retulator signature
NLRP3 pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NLRP3 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NLRP3 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
NLRP3 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
NLRP3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NLRP3 cuproptosis 38414482 In our study, we found two stages of microglia from sham to stroke based on the pseudotime analysis and the CuDEGs: NLRP3 has a critical role in the stage transition. regulator
NLRP3 cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
NLRP3 cuproptosis 37983626 NFE2L2, NLRP3, GLS, LIPT1, and MTF1 were identified as potential cuproptosis predictors, thus shedding new light on ischemic stroke pathogenesis and heterogeneity. predictior
NLRP3 cuproptosis 38348451 Part of the NLRP3 inflammasome, which can be activated in response to cellular stress and contribute to inflammatory processes associated with cuproptosis. CRGs in the cuproptosis pathway
NLRP3 cuproptosis 36050740 A list of the cuproptosis-related genes was obtained from cuproptosis-related studies [18,19,20,21,22]. cuproptosis-related genes
NLRP3 cuproptosis 36195876 We found that all the 18 cuproptosis-related genes have significant value for predicting the prognosis of LIHC patients. Among them, 13 genes are risk factors, including NFE2L2, NLRP3, ATP7A, LIPT1, LIPT2, DLD, DLAT, PDHA1, PDHB, MTF1, GLS, CDKN2A and DLST. And the others are favorable factors, including FDX1, ATP7B, SLC31A1, LIAS and DBT. cuproptosis-related genes
NLRP3 cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Cuproptosis genes related mitochondrial respiration
NLRP3 cuproptosis 36479114 A total of 19 CRGs were analyzed in our following study, such as NFE2L2, NLRP3, ATP7B, ATP7A, SLC31A1, FDX1, LIAS and so on cuproptosis-related genes
NLRP3 cuproptosis 36818726 NLRP3, NFE2L2, ATP7A, LIPT1, GLS and MTF1 may serve as predictors of cuproptosis and play an important role in the pathogenesis of immune infiltration in IS. predictors of cuproptosis

Go Annotation:

GeneSymbol Go id
NLRP3 GO:0000139,GO:0002221,GO:0002674,GO:0002674,GO:0002830,GO:0005515,GO:0005524,GO:0005576,GO:0005634,GO:0005737,GO:0005737,GO:0005737,GO:0005737,GO:0005739,GO:0005783,GO:0005815,GO:0005829,GO:0005829,GO:0006915,GO:0006952,GO:0006954,GO:0006954,GO:0006954,GO:0007165,GO:0007231,GO:0009595,GO:0009595,GO:0016020,GO:0016887,GO:0031021,GO:0032088,GO:0032691,GO:0032731,GO:0032731,GO:0032731,GO:0032753,GO:0035591,GO:0042802,GO:0042834,GO:0043280,GO:0043280,GO:0043531,GO:0043565,GO:0043565,GO:0044546,GO:0045087,GO:0045630,GO:0045944,GO:0050728,GO:0050729,GO:0050729,GO:0051092,GO:0051260,GO:0051604,GO:0060090,GO:0070269,GO:0070273,GO:0071222,GO:0071222,GO:0072559,GO:0072559,GO:0072559,GO:0098586,GO:0140297,GO:0140297,GO:0140299,GO:0140608,GO:0140693,GO:1901223,GO:1901223,GO:1901224,GO:1901981,GO:2000553

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NLRP3 hsa:114548 path:hsa04217 Necroptosis - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05131 Shigellosis - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05132 Salmonella infection - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05133 Pertussis - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05135 Yersinia infection - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05164 Influenza A - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
NLRP3 hsa:114548 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PYCARD NLRP3 11989976 12615073 15030775 17959595 19104081 19158675 19337385 20385749 21575908 23180781 23202296 23702978 24803432 26192618 26885855 27048821 27066895 27439607 27984721 interaction type,physical association anti tag coimmunoprecipitation,two hybrid,fluorescence microscopy ACSN,InnateDB
NLRP3 IL1B 19104081 20385749 23202296 26192618 26885855 27048821 27066895 27439607 27984721 interaction type N/A ACSN
P2RX7 NLRP3 20086177 26192618 interaction type N/A ACSN
CD14 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK2 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
IRAK4 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
LY96 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
MYD88 NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
TIRAP NLRP3 11274345 11964313 12620219 12682231 12907458 14607900 14660645 15749884 15749903 16127449 16243976 16413922 16713974 16878026 17404308 17485448 17704786 18633355 20547845 21372296 21826665 23508573 23681101 23811849 26192618 9743347 interaction type N/A ACSN
SUGT1 NLRP3 17435760 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
HSP90AA1 NLRP3 17435760 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 HSP90AA1 17435760 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 SUGT1 17435760 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRC4 NLRP3 15107016 23180781 physical association anti tag coimmunoprecipitation InnateDB
CARD8 NLRP3 15030775 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 PYCARD 11786556 15030775 16037825 23180781 25686105 physical association affinity chromatography technology,anti tag coimmunoprecipitation,two hybrid InnateDB
NLRP3 CARD8 15030775 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 CASP1 15030775 16037825 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
MEFV NLRP3 17431422 23180781 physical association anti tag coimmunoprecipitation InnateDB
FAF1 NLRP3 17046979 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
NOD2 NLRP3 19337385 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
CASP1 NLRP3 21385879 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 TXNIP 20023662 23180781 24217221 physical association anti tag coimmunoprecipitation InnateDB
TXNIP NLRP3 23180781 24217221 physical association anti tag coimmunoprecipitation InnateDB
DHX33 NLRP3 23180781 23871209 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 MAVS 23180781 24048902 25816776 physical association anti tag coimmunoprecipitation InnateDB
NR1I2 NLRP3 23180781 25202020 physical association anti tag coimmunoprecipitation InnateDB
ABCB1 NLRP3 23180781 25202020 physical association anti tag coimmunoprecipitation InnateDB
CYP3A4 NLRP3 23180781 25202020 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 NLRP3 23180781 25686105 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 DHX33 23180781 25816776 physical association anti tag coimmunoprecipitation InnateDB
FBXL2 NLRP3 23180781 26037928 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 NLRP3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 NLRP3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR NLRP3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 NLRP3 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00001A405B NLRP3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000B7E30 NLRP3 25416803 28302726 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA NLRP3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
SNRPB NLRP3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
HNRNPC NLRP3 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SYK NLRP3 24234451 25348397 25605870 physical association anti tag coimmunoprecipitation ComPPI,IntAct
SH3BP1 NLRP3 25348397 N/A physical interaction ComPPI
HSP90AA1 NLRP3 25348397 N/A physical interaction ComPPI
FAF1 NLRP3 25348397 N/A physical interaction ComPPI
EIF2AK2 NLRP3 22801494 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NECTIN3 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBR5 NLRP3 25348397 N/A physical interaction ComPPI
LTBP4 NLRP3 25348397 N/A physical interaction ComPPI
GEMIN2 NLRP3 25348397 N/A physical interaction ComPPI
CBX5 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H1-5 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YBX3 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HDAC6 NLRP3 25348397 N/A physical interaction ComPPI
MAP1LC3A NLRP3 22286270 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
COPS7A NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PYCARD NLRP3 11786556 14525934 15020601 19158675 24234451 24630722 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,electron microscopy,experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,fluorescence microscopy,in vitro ComPPI,HPRD,IntAct
MEFV NLRP3 25348397 N/A physical interaction ComPPI
AP3B1 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DMAP1 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FBXL2 NLRP3 25348397 26037928 27898060 N/A physical interaction ComPPI,OmniPath
STUB1 NLRP3 25348397 N/A physical interaction ComPPI
MCFD2 NLRP3 25348397 N/A physical interaction ComPPI
SMARCA5 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ULK1 NLRP3 25348397 N/A physical interaction ComPPI
CARD8 NLRP3 25348397 N/A in vivo ComPPI
NLRC4 NLRP3 25348397 N/A physical interaction ComPPI
ARHGAP17 NLRP3 25348397 N/A physical interaction ComPPI
TOP1 NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LUC7L NLRP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 SUGT1 25348397 N/A physical interaction ComPPI
NLRP3 HSP90AA2P 25348397 N/A physical interaction ComPPI
NLRP3 DHX33 25348397 N/A physical interaction ComPPI
NLRP3 RBBP7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 SPAST 25348397 N/A physical interaction ComPPI
NLRP3 PHF14 25348397 N/A physical interaction ComPPI
NLRP3 URB1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 DNAJA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 CBX3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 FBXO28 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 MTCH1 25348397 N/A physical interaction ComPPI
NLRP3 FBXL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 UQCRQ 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 LUC7L3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 FEM1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 PHRF1 25348397 N/A physical interaction ComPPI
NLRP3 CCDC86 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 PCGF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 ZC3H8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 KIAA2013 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 NLRP5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 MARCHF7 25348397 25594175 27898060 N/A physical interaction ComPPI,OmniPath
NLRP3 USP50 25348397 N/A physical interaction ComPPI
NLRP3 MAVS 23582325 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
NLRP3 NEK7 24234451 25348397 26814970 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NLRP3 GPATCH4 24234451 25348397 26496610 association anti tag coimmunoprecipitation ComPPI,IntAct
ARIH2 NLRP3 25348397 N/A physical interaction ComPPI
NLRP3 NLRP3 23582325 24234451 24630722 physical association anti tag coimmunoprecipitation,electron microscopy IntAct
HSPD1 NLRP3 24234451 30021884 physical association cross-linking study IntAct
OR8I2 NLRP3 16169070 30476227 N/A two hybrid TheBiogrid
IZUMO4 NLRP3 16169070 30476227 N/A two hybrid TheBiogrid
NLRP3 LEO1 26186194 28514442 30476227 physical association affinity chromatography technology TheBiogrid
BUD23 NLRP3 27173435 30476227 physical association affinity chromatography technology TheBiogrid
CASP1 NLRP3 11821383 15030775 15190255 16037825 16407888 17382568 17470531 21385879 27898060 N/A N/A OmniPath
NLRP3 FAF1 17046979 27898060 N/A N/A OmniPath
FAF1 NLRP3 17046979 27898060 N/A N/A OmniPath
NOD2 NLRP3 19337385 27898060 N/A N/A OmniPath
NLRP3 PYCARD 11250163 11786556 12615073 15020601 15030775 16037825 16407888 17382568 17470531 19158675 19337385 21575908 21994322 22361007 23066025 24630722 24803432 25686105 27898060 N/A N/A OmniPath
PYCARD NLRP3 11250163 11786556 12615073 15020601 15030775 16037825 16407888 17382568 17470531 19158675 19337385 21575908 21994322 22361007 23066025 24630722 24803432 25686105 27898060 N/A N/A OmniPath
MAVS NLRP3 23582325 24048902 25816776 27898060 stimulant N/A OmniPath
NLRP3 CARD8 11821383 15030775 16407888 17382568 17470531 27898060 N/A N/A OmniPath
NLRC4 NLRP3 15107016 27898060 N/A N/A OmniPath
SUGT1 NLRP3 17435760 27898060 stimulant N/A OmniPath
MEFV NLRP3 17431422 27898060 N/A N/A OmniPath
DHX33 NLRP3 23871209 25816776 27898060 N/A N/A OmniPath

Visualization










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