GENE：IL33
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IL33 |
| FullNmae | interleukin 33 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:16028 |
| EnsembleID | ENSG00000137033 |
| Uniprot | O95760 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IL33 | pyroptosis | 38107476 | While others may exacerbate the condition, such as IL-6, IL-7, IL-15, IL-33, myostatin, fractalkine, follistatin-like 1 (FSTL1), visfatin, activin A, migration inhibitory factor (MIF), apelin and growth differentiation factor (GDF)-15. They exerts anti-/pro-apoptosis/pyroptosis/inflammation, chondrogenic differentiation and cell senescence effect in chondrocyte, synoviocyte and mesenchymal stem cell. | retulator signature |
| IL33 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL33 | necroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| IL33 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IL33 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IL33 | GO:0000122,GO:0001819,GO:0002112,GO:0002282,GO:0002638,GO:0002639,GO:0002686,GO:0002826,GO:0002830,GO:0005125,GO:0005125,GO:0005515,GO:0005576,GO:0005615,GO:0005634,GO:0005654,GO:0005654,GO:0005694,GO:0005737,GO:0006606,GO:0010186,GO:0010467,GO:0010628,GO:0030133,GO:0030225,GO:0032436,GO:0032689,GO:0032722,GO:0032736,GO:0032753,GO:0032754,GO:0032755,GO:0032760,GO:0038172,GO:0042092,GO:0043032,GO:0043032,GO:0043231,GO:0045345,GO:0045348,GO:0045944,GO:0048714,GO:0050729,GO:0050729,GO:0051607,GO:0051770,GO:0061518,GO:0071260,GO:0097191,GO:0106015,GO:0120042,GO:0150078,GO:0150142,GO:0150145 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| IL33 | hsa:90865 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| IL33 | hsa:90865 | path:hsa04217 | Necroptosis - Homo sapiens (human) |
| IL33 | hsa:90865 | path:hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| IL33 | hsa:90865 | path:hsa05164 | Influenza A - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CASP3 | IL33 | 19559631 23180781 | protein cleavage | protease assay | InnateDB |
| IL33 | CASP7 | 19559631 23180781 | protein cleavage | protease assay | InnateDB |
| IL33 | IL1RL1 | 18450470 19439663 19559631 23180781 | physical association | anti tag coimmunoprecipitation,dynamic light scattering,pull down | InnateDB |
| IL33 | RELA | 22708120 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IL33 | PRTN3 | 22270365 22307629 23180781 | protein cleavage | protease assay | InnateDB |
| IL33 | ELANE | 22307629 23180781 | protein cleavage | mass spectrometry studies of complexes,protease assay | InnateDB |
| IL33 | CTSG | 22307629 23180781 | protein cleavage | mass spectrometry studies of complexes,protease assay | InnateDB |
| IL1RL1 | IL33 | 19836339 23180781 23980170 | physical association | molecular sieving,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography | InnateDB |
| IL1RAP | IL33 | 19836339 23180781 | physical association | isothermal titration calorimetry,nuclear magnetic resonance | InnateDB |
| CMA1 | IL33 | 23180781 25313073 | protein cleavage | protease assay | InnateDB |
| GZMB | IL33 | 23180781 25313073 | protein cleavage | protease assay | InnateDB |
| CASP1 | IL33 | 19439663 23180781 | protein cleavage | protease assay | InnateDB |
| IL33 | IL1RAP | 18450470 23180781 | physical association | dynamic light scattering | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CEBPA | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | IL33 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| H2BC4 | IL33 | 18688256 24234451 25348397 | association | pull down | ComPPI,IntAct |
| H2AC11 | IL33 | 18688256 24234451 25348397 27898060 | association,physical association | pull down | ComPPI,IntAct,OmniPath |
| CASP1 | IL33 | 25348397 | N/A | physical interaction,protease assay,protein cleavage | ComPPI |
| H2BC21 | IL33 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | IL33 | 25348397 | N/A | physical interaction | ComPPI |
| H2AC18 | IL33 | 25348397 | N/A | physical interaction | ComPPI |
| CRMP1 | IL33 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| IL1RL1 | IL33 | 14525934 16286016 24234451 25348397 | N/A | experimental interaction detection,pull down,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| USP21 | IL33 | 25348397 | N/A | physical interaction | ComPPI |
| IL33 | USP17L2 | 25348397 | N/A | physical interaction | ComPPI |
| CASP1 | IL33 | 16286016 19439663 27898060 | stimulant | N/A | OmniPath |
| ELANE | IL33 | 22307629 27898060 | N/A | N/A | OmniPath |
| GZMB | IL33 | 25313073 27898060 | N/A | N/A | OmniPath |
| CASP7 | IL33 | 19559631 27898060 | N/A | N/A | OmniPath |
| CASP3 | IL33 | 19559631 27898060 | N/A | N/A | OmniPath |
| IL33 | IL1RL1 | 16286016 18450470 19439663 19559631 19836339 23980170 27898060 | N/A | N/A | OmniPath |
| PRTN3 | IL33 | 22270365 22307629 27898060 | N/A | N/A | OmniPath |
| CMA1 | IL33 | 25313073 27898060 | N/A | N/A | OmniPath |
| CTSG | IL33 | 22307629 27898060 | N/A | N/A | OmniPath |