Gene Information gene info

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GENE：FTL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FTL
FullNmae ferritin light chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3999
EnsembleID ENSG00000087086
Uniprot P02792

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FTL necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTL mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
FTL lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTL autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTL autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FTL GO:0005506,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0008043,GO:0008198,GO:0008199,GO:0016020,GO:0035578,GO:0042802,GO:0044754,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FTL hsa:2512 path:hsa04216 Ferroptosis - Homo sapiens (human)
FTL hsa:2512 path:hsa04217 Necroptosis - Homo sapiens (human)
FTL hsa:2512 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 FTL 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 FTL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FTL 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NFE2L2 FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR FTL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
FTH1 FTL 25361965 interaction type N/A PTMCode2
FTL FTH1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA3 FTL 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FTL FTH1 11591653 14525934 16169070 16189514 21516116 24234451 25348397 25416956 25910212 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
FTL MYOG 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FTL SMAD9 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL MPHOSPH6 14525934 15231747 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
FTL MYOC 14525934 16289162 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FTL GADD45A 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTL PTN 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTL MAP3K12 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FTL TAF10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTL KNG1 12071855 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
FTL PALS2 14525934 15231747 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FTL SPINK7 25348397 N/A physical interaction ComPPI
FTL UCHL5 25348397 N/A physical interaction ComPPI
FTL RAP2A 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL GRB2 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL PIK3CA 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL CLEC4G 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTL TOX4 25348397 N/A physical interaction ComPPI
FTL HSPD1 25348397 N/A physical interaction ComPPI
FTL POLR2D 25348397 N/A physical interaction ComPPI
FTL EIF4G1 25348397 N/A physical interaction ComPPI
FTL PPP1CC 25348397 N/A physical interaction ComPPI
FTL VKORC1 25348397 N/A physical interaction ComPPI
FTL HTT 23275563 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping,two hybrid prey pooling approach ComPPI,IntAct
FTL NAMPT 18486613 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
FTL IGSF8 25348397 N/A physical interaction ComPPI
FTL CERT1 25348397 N/A physical interaction ComPPI
FTL PACSIN2 25348397 N/A physical interaction ComPPI
FTL AURKA 25348397 N/A physical interaction ComPPI
FTL CEP250 25348397 N/A physical interaction ComPPI
FTL CEP57 25348397 N/A physical interaction ComPPI
FTL SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FTL USHBP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
FTL ZDHHC17 24234451 24705354 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FTL MYZAP 25348397 N/A physical interaction ComPPI
FTL POLR2M 25348397 N/A physical interaction ComPPI
FTL LUC7L 25348397 N/A physical interaction ComPPI
FTL LUC7L2 25348397 N/A physical interaction ComPPI
FTL HERC2 24234451 25348397 29426014 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FTL HERC2P3 25348397 N/A physical interaction ComPPI
FTL NCOA4 25348397 N/A physical interaction ComPPI
FTL NKAP 25348397 N/A physical interaction ComPPI
FTL SREK1IP1 25348397 N/A physical interaction ComPPI
FTL ZCCHC17 25348397 N/A physical interaction ComPPI
FTL ZNF263 25348397 N/A physical interaction ComPPI
FTL ZNF558 25348397 N/A physical interaction ComPPI
FTL NOP53 25348397 N/A physical interaction ComPPI
FTL ZNF133 25348397 N/A physical interaction ComPPI
FTL MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
FTL TSG101 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
FTL UBE2DNL 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
FTL PSENEN 23685131 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
FTL NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FTL ECH1 24234451 25348397 29426014 association anti tag coimmunoprecipitation ComPPI,IntAct
FTL FTL 11591653 14525934 16169070 16189514 16790936 24234451 25416956 25910212 physical association experimental interaction detection,x-ray crystallography,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid HPRD,IntAct
IGDCC3 FTL 11591653 14525934 N/A experimental interaction detection HPRD

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