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GENE：SHARPIN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SHARPIN
FullNmae SHANK associated RH domain interactor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25321
EnsembleID ENSG00000179526
Uniprot Q9H0F6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SHARPIN necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SHARPIN necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
SHARPIN GO:0004842,GO:0005515,GO:0005829,GO:0005829,GO:0007005,GO:0010803,GO:0030262,GO:0030425,GO:0031424,GO:0031593,GO:0042742,GO:0042802,GO:0043123,GO:0043123,GO:0043130,GO:0043161,GO:0044877,GO:0045202,GO:0046872,GO:0050728,GO:0071797,GO:0071797,GO:0071797,GO:0097039,GO:0097039,GO:2000348

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SHARPIN hsa:81858 path:hsa04217 Necroptosis - Homo sapiens (human)
SHARPIN hsa:81858 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
SHARPIN hsa:81858 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RBCK1 SHARPIN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 21709223 23180781 24699077 24958845 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RNF31 SHARPIN 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845 26192618 interaction type N/A ACSN
SHARPIN IKBKG 11280761 11460167 14660645 17301840 18264787 21133840 21232017 24699077 24958845 26192618 interaction type N/A ACSN
IKBKG SHARPIN 21709223 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 SHARPIN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SHARPIN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 SHARPIN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SHARPIN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SHARPIN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SHARPIN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
SHANK1 SHARPIN 25361965 interaction type N/A PTMCode2
SHARPIN SHANK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPATA2 SHARPIN 25348397 N/A physical interaction ComPPI
TXN2 SHARPIN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNFAIP3 SHARPIN 23032186 24234451 25348397 30561431 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
ITGB1 SHARPIN 21947080 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
UBB SHARPIN 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
UBC SHARPIN 25348397 N/A isothermal titration calorimetry,pull down,physical interaction,physical interaction ComPPI
RPS27A SHARPIN 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
UBA52 SHARPIN 25348397 N/A isothermal titration calorimetry,pull down,physical interaction ComPPI
IKBKB SHARPIN 21455180 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF1A SHARPIN 25348397 N/A physical interaction ComPPI
ITGB2 SHARPIN 25348397 N/A physical interaction ComPPI
PDLIM7 SHARPIN 25348397 N/A physical interaction ComPPI
TNF SHARPIN 23032186 23104095 23955153 24234451 25348397 30561431 association anti tag coimmunoprecipitation,pull down,physical interaction,virotrap ComPPI,IntAct
RABGEF1 SHARPIN 25348397 N/A physical interaction ComPPI
TRAF1 SHARPIN 25348397 N/A physical interaction ComPPI
LMO2 SHARPIN 25348397 N/A physical interaction ComPPI
MDM2 SHARPIN 25348397 N/A physical interaction ComPPI
SHANK1 SHARPIN 11178875 12753155 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ITGA1 SHARPIN 25348397 N/A physical interaction ComPPI
CHUK SHARPIN 21455180 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTEN SHARPIN 20458142 25152374 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ITGA2 SHARPIN 21947080 24234451 25348397 association,physical association anti bait coimmunoprecipitation,fluorescence polarization spectroscopy,pull down,physical interaction ComPPI,IntAct
TFAP2C SHARPIN 24234451 24835590 25348397 physical association two hybrid ComPPI,IntAct
BIRC2 SHARPIN 24234451 25348397 27070702 association anti bait coimmunoprecipitation ComPPI,IntAct
BIRC3 SHARPIN 24234451 25348397 27070702 association anti bait coimmunoprecipitation ComPPI,IntAct
ITGAM SHARPIN 25348397 N/A physical interaction ComPPI
BCL10 SHARPIN 24234451 25348397 27070702 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LTBR SHARPIN 25348397 N/A physical interaction ComPPI
ESR1 SHARPIN 25348397 N/A physical interaction ComPPI
TLR3 SHARPIN 25348397 N/A physical interaction ComPPI
AURKB SHARPIN 25348397 N/A physical interaction ComPPI
NOD2 SHARPIN 25348397 N/A physical interaction ComPPI
IL1A SHARPIN 21947080 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MALT1 SHARPIN 24234451 25348397 27070702 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SHARPIN ITGA5 21947080 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,physical interaction ComPPI,IntAct
SHARPIN IKBKG 21455180 21709223 23032186 24234451 25348397 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,virotrap ComPPI,IntAct
SHARPIN RBCK1 21455180 21455181 23032186 24234451 25348397 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction,virotrap ComPPI,IntAct
SHARPIN RNF31 21455180 21455181 22158122 23032186 23104095 23746843 24141947 24234451 24461064 24726327 25348397 26600301 26670046 27898060 30561431 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,virotrap ComPPI,IntAct,OmniPath
SHARPIN SHANK2 25348397 N/A physical interaction ComPPI
SHARPIN ITGAL 24210817 25348397 26600301 27898060 N/A physical interaction ComPPI,OmniPath
SHARPIN ITGAD 25348397 N/A physical interaction ComPPI
SHARPIN LIPF 25348397 N/A physical interaction ComPPI
SHARPIN CYLD 25348397 N/A physical interaction ComPPI
SHARPIN KCTD7 25348397 N/A physical interaction ComPPI
SHARPIN YOD1 25348397 N/A physical interaction ComPPI
OTULIN SHARPIN 25348397 N/A physical interaction ComPPI
SHARPIN SHARPIN 11178875 14525934 24234451 30561431 association experimental interaction detection,virotrap HPRD,IntAct
SHARPIN VPS37D 24234451 30561431 association virotrap IntAct
SHARPIN SEMA4G 24234451 30561431 association virotrap IntAct
SHARPIN MOXD1 24234451 30561431 association virotrap IntAct
SHARPIN MEAK7 24234451 30561431 association virotrap IntAct
SHARPIN PDPN 24234451 30561431 association virotrap IntAct
SHARPIN MKRN4P 24234451 30561431 association virotrap IntAct
SHARPIN MKRN2 24234451 30561431 association virotrap IntAct
SHARPIN RTL6 24234451 30561431 association virotrap IntAct
SHARPIN TRAF3 24234451 30561431 association virotrap IntAct
SHARPIN TENM3 24234451 30561431 association virotrap IntAct
SHARPIN TAB1 24234451 30561431 association virotrap IntAct
SHARPIN NCS1 24234451 30561431 association virotrap IntAct
SHARPIN MAP3K7 24234451 30561431 association virotrap IntAct
SHARPIN HPRT1 24234451 30561431 association virotrap IntAct
SHARPIN ULBP3 24234451 30561431 association virotrap IntAct
SHARPIN TNIP1 24234451 30561431 association virotrap IntAct
SHARPIN TNIP2 24234451 30561431 association virotrap IntAct
SHARPIN GDI1 24234451 30561431 association virotrap IntAct
SHARPIN ULK3 24234451 30561431 association virotrap IntAct
SHARPIN TAB2 24234451 30561431 association virotrap IntAct
SHARPIN DHFR 24234451 30561431 association virotrap IntAct
SHARPIN UEVLD 24234451 30561431 association virotrap IntAct
SHARPIN S1PR2 24234451 30561431 association virotrap IntAct
SHARPIN ORAI1 24234451 30561431 association virotrap IntAct
SHARPIN FZD7 24234451 30561431 association virotrap IntAct
SHARPIN DNAJB4 24234451 30561431 association virotrap IntAct
SHARPIN RAB9A 24234451 30561431 association virotrap IntAct
SHARPIN PHB2 24234451 30561431 association virotrap IntAct
SHARPIN ZCCHC3 24234451 30561431 association virotrap IntAct
SHARPIN UMAD1 24234451 30561431 association virotrap IntAct
EYA1 SHARPIN 20956555 27898060 N/A N/A OmniPath
IKBKG SHARPIN 21455180 21709223 23032186 23986494 27898060 N/A N/A OmniPath

Visualization










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