Gene Information gene info

  1. Home

GENE：USP21

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol USP21
FullNmae ubiquitin specific peptidase 21
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12620
EnsembleID ENSG00000143258
Uniprot Q9UK80

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
USP21 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
USP21 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
USP21 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
USP21 GO:0003713,GO:0004843,GO:0004843,GO:0004843,GO:0004843,GO:0005515,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0006508,GO:0008234,GO:0008234,GO:0019784,GO:0045815,GO:0045893,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
USP21 hsa:27005 path:hsa04217 Necroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 USP21 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A USP21 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 USP21 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 USP21 20554955 23395819 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
PRDM14 USP21 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS USP21 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 USP21 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002FC5B0 USP21 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EC1BE USP21 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002B7450 USP21 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC USP21 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 USP21 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
FAM110A USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP20 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BHLHE40 USP21 25348397 N/A physical interaction ComPPI
PPIB USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCTD9 USP21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EFEMP2 USP21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ISG15 USP21 25348397 N/A physical interaction ComPPI
JOSD1 USP21 25348397 N/A physical interaction ComPPI
TRAF6 USP21 25348397 N/A physical interaction ComPPI
FAM53C USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KRT40 USP21 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KCTD6 USP21 25348397 N/A physical interaction ComPPI
CBY1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RBM8A USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBL USP21 25348397 N/A physical interaction ComPPI
TIAM1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MAPK3 USP21 25348397 N/A physical interaction ComPPI
GAB2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CBLC USP21 25348397 N/A physical interaction ComPPI
USP7 USP21 25348397 N/A physical interaction ComPPI
HDAC4 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GLI1 USP21 25348397 N/A physical interaction ComPPI
GLI2 USP21 25348397 N/A physical interaction ComPPI
RTKN USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ARHGEF2 USP21 25348397 N/A physical interaction ComPPI
CUL3 USP21 25348397 N/A physical interaction ComPPI
UBB USP21 25348397 N/A fluorescent resonance energy transfer,physical interaction ComPPI
UBC USP21 20622874 21399617 22195557 22298430 22626734 23287719 25348397 25527291 27898060 N/A fluorescent resonance energy transfer,physical interaction ComPPI,OmniPath
RPS27A USP21 25348397 N/A fluorescent resonance energy transfer,physical interaction ComPPI
UBA52 USP21 25348397 N/A fluorescent resonance energy transfer,physical interaction ComPPI
MAGI1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PHLDB2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MARK4 USP21 25348397 N/A physical interaction ComPPI
RAB3IP USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
UTRN USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAD51 USP21 25348397 N/A physical interaction ComPPI
BRCA2 USP21 25348397 N/A physical interaction ComPPI
XPO1 USP21 25348397 N/A physical interaction ComPPI
H2AC18 USP21 25348397 N/A physical interaction ComPPI
USP4 USP21 25348397 N/A physical interaction ComPPI
EXOSC10 USP21 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TRIM23 USP21 25348397 N/A physical interaction ComPPI
MARK2 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MELK USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM63 USP21 25348397 N/A physical interaction ComPPI
PRKCI USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SH3PXD2A USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TBC1D25 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP8 USP21 25348397 N/A physical interaction ComPPI
AURKA USP21 25348397 N/A physical interaction ComPPI
RIPK1 USP21 25348397 N/A physical interaction ComPPI
UCHL1 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATXN3 USP21 25348397 N/A physical interaction ComPPI
USP33 USP21 25348397 N/A physical interaction ComPPI
UPF3B USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SYNE1 USP21 25348397 N/A physical interaction ComPPI
CDK16 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MARK3 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MPP1 USP21 25348397 N/A physical interaction ComPPI
BAZ2A USP21 25348397 N/A physical interaction ComPPI
KIF13B USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25B USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIF1C USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TESK2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
STAMBP USP21 25348397 N/A physical interaction ComPPI
LRSAM1 USP21 25348397 N/A physical interaction ComPPI
BAP1 USP21 25348397 N/A physical interaction ComPPI
ZNF350 USP21 25348397 N/A physical interaction ComPPI
CKAP5 USP21 25348397 N/A physical interaction ComPPI
HECW2 USP21 25348397 N/A physical interaction ComPPI
MARK1 USP21 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SRGAP2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DTX3 USP21 25348397 N/A physical interaction ComPPI
ZNF638 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SENP3 USP21 25348397 N/A physical interaction ComPPI
SIPA1L1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PCGF6 USP21 25348397 N/A physical interaction ComPPI
UCHL3 USP21 25348397 N/A physical interaction ComPPI
TRIM8 USP21 25348397 N/A physical interaction ComPPI
RNF144A USP21 25348397 N/A physical interaction ComPPI
RASAL2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SH3BP4 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZBTB21 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF4E2 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM54 USP21 25348397 N/A physical interaction ComPPI
KCTD3 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM5 USP21 25348397 N/A physical interaction ComPPI
MAP4 USP21 25348397 N/A physical interaction ComPPI
HOXC10 USP21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
USP21 FUCA1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP21 ANKRD28 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP21 PPP6R3 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP21 USP48 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP21 RBM45 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
USP21 UBE2S 25348397 N/A physical interaction ComPPI
USP21 USP51 25348397 N/A physical interaction ComPPI
USP21 OTUB1 25348397 N/A physical interaction ComPPI
USP21 OTUB2 25348397 N/A physical interaction ComPPI
USP21 USP15 25348397 N/A physical interaction ComPPI
USP21 USP28 25348397 N/A physical interaction ComPPI
USP21 ESPL1 25348397 N/A physical interaction ComPPI
USP21 SENP8 25348397 N/A physical interaction ComPPI
USP21 USP14 25348397 N/A physical interaction ComPPI
USP21 USP2 25348397 N/A physical interaction ComPPI
USP21 RBCK1 25348397 N/A physical interaction ComPPI
USP21 RNF185 25348397 N/A physical interaction ComPPI
USP21 GATA3 25348397 N/A physical interaction ComPPI
USP21 DDX58 24493797 25348397 27898060 N/A physical interaction ComPPI,OmniPath
USP21 IFIH1 25348397 N/A physical interaction ComPPI
USP21 DHX58 25348397 N/A physical interaction ComPPI
USP21 IL33 25348397 N/A physical interaction ComPPI
USP21 NANOGP8 25348397 N/A physical interaction ComPPI
USP21 NANOG 25348397 N/A physical interaction ComPPI
USP21 WDR47 25348397 N/A physical interaction ComPPI
USP21 SLF1 25348397 N/A physical interaction ComPPI
USP21 KCTD11 25348397 N/A physical interaction ComPPI
USP21 TP53 25348397 N/A physical interaction ComPPI
USP21 KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 FAM110B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 ANKRD34A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 MAPKAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 NADK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 MAP3K21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 AFDN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 DEPDC1B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
USP21 PLEKHA7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TRIM9 USP21 25348397 N/A physical interaction ComPPI
AGAP1 USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BEND3 USP21 19615732 24234451 25348397 26100909 27898060 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
YOD1 USP21 25348397 N/A physical interaction ComPPI
NEDD8 USP21 27898060 9353319 N/A N/A OmniPath

Visualization










  Return