GENE：ABCB6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ABCB6 |
| FullNmae | ATP binding cassette subfamily B member 6 (LAN blood group) |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:47 |
| EnsembleID | ENSG00000115657 |
| Uniprot | Q9NP58 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ABCB6 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ABCB6 | cuproptosis | 36466876 | Overall, 25 CuDEGs were identified, including ABCB6, BACE1, FDX1, GLS, LIAS, MT1M, PDHA1, etc. | retulator signature |
| ABCB6 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| ABCB6 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.26 database. |
| ABCB6 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ABCB6 | GO:0000139,GO:0005524,GO:0005654,GO:0005739,GO:0005739,GO:0005740,GO:0005741,GO:0005741,GO:0005765,GO:0005768,GO:0005774,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0006778,GO:0006778,GO:0006779,GO:0006878,GO:0006879,GO:0007420,GO:0015439,GO:0015439,GO:0015439,GO:0015562,GO:0015886,GO:0015886,GO:0015886,GO:0016887,GO:0020037,GO:0020037,GO:0031901,GO:0032585,GO:0033013,GO:0033162,GO:0035351,GO:0036020,GO:0042168,GO:0043190,GO:0043588,GO:0046906,GO:0055085,GO:0070062,GO:0070062,GO:0098849,GO:0140359,GO:0140359,GO:0140359,GO:1903232 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ABCB6 | hsa:10058 | path:hsa02010 | ABC transporters - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ABCB6 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | ABCB6 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | ABCB6 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| MYC | ABCB6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMI1 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| DPEP1 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R3 | ABCB6 | 18624398 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TNF | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| SDCBP | ABCB6 | 24234451 25348397 26787460 | N/A | phage display | ComPPI,IntAct |
| FANCD2 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| RNF2 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| TSG101 | ABCB6 | 19549727 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
| TOLLIP | ABCB6 | 21903422 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| GRPR | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| GNAI2 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| CLEC2D | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| TOMM40 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| RNF126 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| FLOT2 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| HLA-DPA1 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| ERGIC3 | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| ABCB6 | CEACAM21 | 25348397 | N/A | physical interaction | ComPPI |
| ABCB6 | MRAP2 | 25348397 | N/A | physical interaction | ComPPI |
| ABCB6 | PCDHA12 | 25348397 | N/A | physical interaction | ComPPI |
| DCT | ABCB6 | 25348397 | N/A | physical interaction | ComPPI |
| TOLLIP | ABCB6 | 21903422 27898060 | N/A | N/A | OmniPath |