GENE:ACADM
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ACADM |
| FullNmae | acyl-CoA dehydrogenase medium chain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:89 |
| EnsembleID | ENSG00000117054 |
| Uniprot | P11310 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ACADM | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ACADM | GO:0001889,GO:0003995,GO:0003995,GO:0005634,GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005978,GO:0006111,GO:0006635,GO:0009409,GO:0009791,GO:0019254,GO:0030424,GO:0031966,GO:0033539,GO:0033539,GO:0042594,GO:0042802,GO:0045329,GO:0050660,GO:0051791,GO:0051793,GO:0051793,GO:0055007,GO:0070991,GO:0070991 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ACADM | hsa:34 | path:hsa00071 | Fatty acid degradation - Homo sapiens (human) |
| ACADM | hsa:34 | path:hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| ACADM | hsa:34 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ACADM | hsa:34 | path:hsa01212 | Fatty acid metabolism - Homo sapiens (human) |
| ACADM | hsa:34 | path:hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| ACADM | hsa:34 | path:hsa04936 | Alcoholic liver disease - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ACADM | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ACADM | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ACADM | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| MYC | ACADM | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ACADM | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| USP20 | ACADM | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RPN1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| LDHB | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| LDHA | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R1A | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| JUN | ACADM | 24234451 25348397 25609649 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CUL3 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| CTSD | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| NTRK1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| CANX | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| HSP90B1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| VDAC1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| ANG | ACADM | 24234451 25348397 28777577 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RAB2A | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| VDAC2 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| ATP1A1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| STRAP | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| UQCRC2 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| IDH3A | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| CAND1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| SUCLG2 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| SUCLA2 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| PDK1 | ACADM | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| CLPP | ACADM | 24234451 25348397 26058080 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| ARF4 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| PPP2R1B | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| PRKCSH | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| SEC63 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| ATP6V1A | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| DNAJA1 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| FAF2 | ACADM | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | SUMO4 | 14525934 16236267 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ACADM | USP50 | 19615732 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ACADM | HDAC1 | 23752268 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ACADM | AASS | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | AHSA1 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | ARF1 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | ARF5 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | ATP9A | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | CCT6B | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | GALE | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | NFS1 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | SLC25A3 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | TECR | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | ATP5F1C | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | DDOST | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | DDX39B | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | ETFA | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | GFPT1 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | GFPT2 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | HIBCH | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | PSMC2 | 25348397 | N/A | physical interaction | ComPPI |
| ACADM | GABARAPL1 | 20562859 24234451 25348397 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| ACADM | HSPD1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| MGST3 | ACADM | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TRMT61B | ACADM | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| ACADM | ACADM | 14525934 24234451 3597357 8823176 | N/A | experimental interaction detection,molecular sieving | HPRD,IntAct |
| PNKD | ACADM | 24234451 30021884 | physical association | cross-linking study | IntAct |
