Gene Information gene info

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GENE：B2M

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol B2M
FullNmae beta-2-microglobulin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:914
EnsembleID ENSG00000166710
Uniprot P61769

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
B2M mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
B2M GO:0000139,GO:0001895,GO:0001913,GO:0001916,GO:0002237,GO:0002481,GO:0002503,GO:0002726,GO:0005515,GO:0005576,GO:0005615,GO:0005765,GO:0005788,GO:0005794,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006826,GO:0006879,GO:0007608,GO:0007611,GO:0007611,GO:0009897,GO:0010977,GO:0012507,GO:0016020,GO:0019885,GO:0019886,GO:0023026,GO:0030670,GO:0031901,GO:0031902,GO:0031905,GO:0032092,GO:0033077,GO:0034756,GO:0035580,GO:0042026,GO:0042605,GO:0042612,GO:0042612,GO:0042613,GO:0042802,GO:0042803,GO:0042824,GO:0045646,GO:0048260,GO:0050680,GO:0050768,GO:0050778,GO:0050870,GO:0051289,GO:0055038,GO:0060586,GO:0070062,GO:0071281,GO:0071283,GO:0071316,GO:1900121,GO:1900122,GO:1904434,GO:1904437,GO:1904724,GO:1990000,GO:1990712,GO:2000774,GO:2000978

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
B2M hsa:567 path:hsa04612 Antigen processing and presentation - Homo sapiens (human)
B2M hsa:567 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
B2M hsa:567 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
B2M hsa:567 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
B2M hsa:567 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
B2M hsa:567 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
B2M LCK 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 26192618 8642276 interaction type N/A ACSN
B2M CD247 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 26192618 8642276 interaction type N/A ACSN
B2M PTPRC 10358761 10559964 11154916 11509172 11717192 14508489 16181333 22076556 22790179 24457417 26192618 8642276 interaction type N/A ACSN
CALR B2M 14508489 16181333 16239148 17204652 20958319 22076556 23157435 23850759 26192618 interaction type N/A ACSN
PDIA3 B2M 14508489 16181333 16239148 17204652 20958319 22076556 23157435 23850759 26192618 interaction type N/A ACSN
B2M USF2 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay,enzymatic study InnateDB
B2M USF1 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay,enzymatic study InnateDB
B2M IRF2 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M IRF1 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M IRF4 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M IRF8 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M NFKB1 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M RELA 12480693 23180781 physical association electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
B2M KLRD1 18083576 18448674 23180781 physical association surface plasmon resonance,x-ray crystallography InnateDB
B2M KLRC1 18083576 18448674 23180781 physical association surface plasmon resonance,x-ray crystallography InnateDB
B2M HLA-E 18448674 23180781 physical association x-ray crystallography InnateDB
B2M PABPC1 17267406 23180781 physical association anti tag coimmunoprecipitation InnateDB
B2M MEX3A 17267406 23180781 physical association anti tag coimmunoprecipitation InnateDB
B2M MEX3B 17267406 23180781 physical association anti tag coimmunoprecipitation InnateDB
MEX3C B2M 17267406 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR B2M 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 B2M 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 B2M 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 B2M 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 B2M 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 B2M 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 B2M 12480693 trascriptional regulation,stimulation inferred by curator TFlink
USF1 B2M 12480693 trascriptional regulation,stimulation inferred by curator TFlink
USF2 B2M 12480693 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000DDD35 B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00002075FA B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 B2M 20371350 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000017EE98 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016FF9C B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CAE0C B2M 20371350 21572407 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C5BAA B2M 20371350 21572407 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001EE123 B2M 20371350 21572407 23446348 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000023BE29 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 B2M 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C B2M 20371350 21572407 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEE35 B2M 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000544FF1 B2M 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
B2M B2M 25361965 interaction type N/A PTMCode2
HLA-G B2M 25361965 interaction type N/A PTMCode2
B2M HLA-G 25361965 interaction type N/A PTMCode2
B2M HLA-A 25361965 interaction type N/A PTMCode2
HLA-A B2M 25361965 interaction type N/A PTMCode2
B2M HLA-E 25361965 interaction type N/A PTMCode2
HLA-E B2M 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 B2M 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
UBE2I B2M 25348397 N/A physical interaction ComPPI
KPNA3 B2M 25348397 N/A physical interaction ComPPI
KPNA4 B2M 25348397 N/A physical interaction ComPPI
TFRC B2M 10638746 20133674 24234451 25348397 association,physical association pull down,x-ray crystallography,physical interaction ComPPI,IntAct
CRYAB B2M 25348397 N/A physical interaction ComPPI
PCNA B2M 23527218 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LIN37 B2M 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
INS B2M 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
GRB2 B2M 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KPNB1 B2M 25348397 N/A physical interaction ComPPI
TAP2 B2M 25348397 N/A physical interaction ComPPI
TAP1 B2M 17055437 18802093 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TAPBP B2M 25348397 N/A physical interaction ComPPI
MAP1S B2M 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCOLCE B2M 24117177 24234451 25348397 N/A two hybrid,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
BAG6 B2M 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CALR B2M 14525934 24234451 25241761 25348397 8769474 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
LILRB2 B2M 17056715 24234451 25348397 27649529 physical association surface plasmon resonance,x-ray crystallography,surface plasmon resonance array ComPPI,IntAct
CFTR B2M 25348397 N/A physical interaction ComPPI
RANGAP1 B2M 25348397 N/A physical interaction ComPPI
CD8A B2M 11914379 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CD1D B2M 10221650 11257307 14525934 17581592 24234451 25348397 27898060 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
HFE B2M 10791995 14525934 15965644 20618438 24234451 25348397 27898060 9546397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
MAPK15 B2M 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TPST1 B2M 25348397 N/A physical interaction ComPPI
B2M HLA-A 11502003 1448153 14525934 24163410 24234451 25348397 26439010 27649529 93026 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
B2M HLA-B 10975842 11738047 12244049 14525934 1525820 17057332 24234451 2450918 25348397 26186194 26439010 27649529 27898060 8624811 8624812 8976183 physical association experimental interaction detection,fluorescence polarization spectroscopy,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct,OmniPath
B2M HLA-G 14525934 17056715 24234451 25348397 27898060 9228302 physical association experimental interaction detection,x-ray crystallography,in vivo ComPPI,HPRD,IntAct,OmniPath
B2M HLA-E 10064069 14525934 25348397 9605335 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD
B2M HLA-F 11169396 14525934 20483783 24234451 25348397 27649529 physical association experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
B2M CD1B 12118248 14525934 14764708 24234451 25348397 27898060 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
B2M CD1A 12833155 14525934 15723809 24234451 25348397 27898060 N/A experimental interaction detection,x-ray crystallography,in vitro ComPPI,HPRD,IntAct,OmniPath
B2M CD1E 10948205 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
B2M FCGRT 10933786 12006623 14525934 24234451 25348397 27898060 N/A experimental interaction detection,x-ray crystallography,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
B2M LILRB1 24234451 25348397 27649529 physical association surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,IntAct
B2M PRSS23 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
B2M A2M 10731476 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
B2M CXCR4 25348397 N/A physical interaction ComPPI
B2M HLA-C 10429675 14525934 24234451 2450918 25348397 27649529 28546555 physical association experimental interaction detection,fluorescence-activated cell sorting,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
B2M HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
B2M ERBB3 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
B2M RGPD2 25348397 N/A physical interaction ComPPI
B2M RGPD5 25348397 N/A physical interaction ComPPI
B2M DLGAP5 25348397 N/A physical interaction ComPPI
B2M RANBP2 25348397 N/A physical interaction ComPPI
B2M CDCA2 25348397 N/A physical interaction ComPPI
B2M NUSAP1 25348397 N/A physical interaction ComPPI
B2M NEMP1 25348397 N/A physical interaction ComPPI
B2M PPAT 25348397 N/A physical interaction ComPPI
B2M RANGRF 25348397 N/A physical interaction ComPPI
B2M MR1 23051753 25348397 27898060 N/A molecular sieving,x-ray crystallography,physical interaction,ion exchange chromatography ComPPI,OmniPath
B2M LIN54 17531812 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
B2M EBI3 24018270 24234451 25348397 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
B2M CD244 20164429 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
B2M NCR2 20164429 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
B2M KIR3DL1 24234451 25348397 27649529 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
B2M KIR3DS1 24234451 25348397 27649529 physical association surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
B2M B2M 12023961 14525934 17108084 18579777 19172750 19564620 20826442 21131979 21220305 21569201 22289140 22575645 24234451 covalent binding classical fluorescence spectroscopy,transmission electron microscopy,cosedimentation in solution,electron microscopy,experimental interaction detection,fluorescence technology,mass spectrometry studies of complexes,molecular sieving,nuclear magnetic resonance,x-ray crystallography,electron tomography,comigration in sds page,x-ray fiber diffraction,atomic force microscopy,solid state nmr HPRD,IntAct
CHRM4 B2M 24234451 28298427 physical association ubiquitin reconstruction IntAct
B2M OTOF 24234451 30021884 physical association cross-linking study IntAct
B2M HMCN1 24234451 30021884 physical association cross-linking study IntAct
B2M OSBP 24234451 30021884 physical association cross-linking study IntAct
B2M MORC2 24234451 30021884 physical association cross-linking study IntAct
B2M CALR 10618487 25241761 27898060 8769474 9597133 N/A N/A OmniPath
B2M TAP1 10618487 17055437 27898060 N/A N/A OmniPath
B2M PDIA3 10618487 27898060 9597133 N/A N/A OmniPath
B2M CANX 27898060 9597133 N/A N/A OmniPath
B2M TAP2 10618487 27898060 N/A N/A OmniPath
B2M TAPBP 10618487 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AD303 B2M 27087310 direct interaction,inhibition N/A NPInter

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