GENE：CCK
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CCK |
| FullNmae | cholecystokinin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1569 |
| EnsembleID | ENSG00000187094 |
| Uniprot | P06307 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CCK | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CCK | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CCK | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CCK | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CCK | GO:0001764,GO:0005179,GO:0005184,GO:0005184,GO:0005515,GO:0005576,GO:0005615,GO:0007165,GO:0007409,GO:0007586,GO:0030424,GO:0030424,GO:0042755,GO:0051428 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CCK | hsa:885 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| CCK | hsa:885 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| CCK | hsa:885 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CCK | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CCK | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | CCK | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SP1 | CCK | 8561897 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| CTCF | CCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | CCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | CCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | CCK | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | CCK | 15030385 15073527 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREBBP | CCK | 15030385 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EWSR1 | CCK | 17438102 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | CCK | 17438102 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CCK | 1360635 7693011 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | CCK | 1360635 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | CCK | 11022044 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | CCK | 11022044 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | CCK | 8561897 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBQLN2 | CCK | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CCKAR | CCK | 10400673 10595537 11300760 14525934 25348397 9006937 9603948 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CCKBR | CCK | 10438490 12695525 14525934 15001692 15068617 15520004 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| CPE | CCK | 12479974 14525934 9275097 | N/A | experimental interaction detection | HPRD |
| MEP1A | CCK | 11278902 14525934 | N/A | experimental interaction detection | HPRD |
| MEP1B | CCK | 11278902 14525934 | N/A | experimental interaction detection | HPRD |
| ENPEP | CCK | 14525934 8804068 | N/A | experimental interaction detection | HPRD |
| CCK | CCKBR | 10368033 10438490 12695525 15001692 15068617 15520004 27898060 8349705 | stimulant | N/A | OmniPath |
| CCK | CCKAR | 10368033 10400673 10595537 11300760 27898060 9006937 9603948 | stimulant | N/A | OmniPath |
| CPE | CCK | 12479974 27898060 9275097 | N/A | N/A | OmniPath |
| ENPEP | CCK | 27898060 8804068 | inhibition | N/A | OmniPath |