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GENE：EIF2AK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol EIF2AK1
FullNmae eukaryotic translation initiation factor 2 alpha kinase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24921
EnsembleID ENSG00000086232
Uniprot Q9BQI3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
EIF2AK1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
EIF2AK1 GO:0002526,GO:0004694,GO:0004694,GO:0005515,GO:0005524,GO:0005634,GO:0005737,GO:0006468,GO:0006909,GO:0008285,GO:0010999,GO:0020037,GO:0030225,GO:0042803,GO:0045993,GO:0046501,GO:0046777,GO:0046986,GO:0051649,GO:0060586,GO:0106310,GO:0140467,GO:0140468,GO:1990641

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
EIF2AK1 hsa:27102 path:hsa05160 Hepatitis C - Homo sapiens (human)
EIF2AK1 hsa:27102 path:hsa05162 Measles - Homo sapiens (human)
EIF2AK1 hsa:27102 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 EIF2AK1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 EIF2AK1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 EIF2AK1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 EIF2AK1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 EIF2AK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 EIF2AK1 19133234 trascriptional regulation,stimulation inferred by curator TFlink
EP300 EIF2AK1 19133234 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 EIF2AK1 19133234 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 EIF2AK1 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 EIF2AK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 EIF2AK1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 EIF2AK1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
EIF2AK1 EIF2S1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
EIF2AK1 CDC37 25361965 interaction type N/A PTMCode2
CDC37 EIF2AK1 25361965 interaction type N/A PTMCode2
EIF2AK1 EIF2AK2 25361965 interaction type N/A PTMCode2
EIF2AK2 EIF2AK1 25361965 interaction type N/A PTMCode2
EIF2S1 EIF2AK1 25361965 interaction type N/A PTMCode2
EIF2AK1 HSP90AA1 25361965 interaction type N/A PTMCode2
HSP90AA1 EIF2AK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MFAP1 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HSPA8 EIF2AK1 24234451 25348397 29568061 association pull down ComPPI,IntAct
DELE1 EIF2AK1 25348397 N/A physical interaction ComPPI
CDK6 EIF2AK1 25348397 N/A physical interaction ComPPI
HSP90AB1 EIF2AK1 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
DDX20 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
LIG4 EIF2AK1 25348397 N/A physical interaction ComPPI
HSP90AA1 EIF2AK1 11036079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RBM14 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2S1 EIF2AK1 10542257 14525934 1677563 25348397 9819435 N/A experimental interaction detection,in vivo ComPPI,HPRD
MDM2 EIF2AK1 25348397 N/A physical interaction ComPPI
FASLG EIF2AK1 25348397 N/A physical interaction ComPPI
POLD1 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ATRX EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
AP3B1 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC37 EIF2AK1 11036079 14525934 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
EAF1 EIF2AK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2AK1 HSP90AA2P 25348397 N/A physical interaction ComPPI
EIF2AK1 NAF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF2AK1 EIF2AK1 12767237 14525934 N/A experimental interaction detection HPRD
H1-5 EIF2AK1 24234451 30021884 physical association cross-linking study IntAct
EIF2AK1 EIF2S1 10542257 10563826 11041858 11337501 15550948 1677563 24714526 27898060 3352609 9819435 9930704 inhibition,stimulant N/A OmniPath

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