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GENE：FXN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FXN
FullNmae frataxin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3951
EnsembleID ENSG00000165060
Uniprot Q16595

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FXN mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FXN apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FXN apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FXN cuproptosis 36313717 Proteins carrying iron-sulfur clusters are essential for the basic metabolism of all organisms. Eukaryotic iron-sulfur cluster assembly includes direct mitochondrial iron-sulfur cluster (ISC) co-assembly pathway and cytosolic iron-sulfur cluster assembly (CIA) pathway that uses active sulfur as substrate, these pathways containing protein complex (composed of cysteine desulfurase, a scaffold protein, auxiliary ISD11 protein, acyl carrier protein, frataxin, and ferredoxin), the related genes (including NFS1, ISD11, ACP1, ISCU2, FXN, FDX2, FDXR) and proteins of cytokine induced apoptosis inhibitor 1 (CIAPIN1), novel diflavin oxidoreductase 1 (NDOR1), nucleotide binding protein 2 (NUBP2), nucleotide binding protein 1 (NUBP1), iron-only hydrogenase-like protein 1 (IOP1), and Cytosolic iron-Sulfur assembly component 1 (CIAO1) Proteins carrying iron-sulfur cluster
FXN cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in聽Table S1. Genes of iron-sulfur cluster related proteins

Go Annotation:

GeneSymbol Go id
FXN GO:0004322,GO:0004322,GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005759,GO:0005829,GO:0006119,GO:0006783,GO:0006879,GO:0006879,GO:0007005,GO:0007628,GO:0008198,GO:0008198,GO:0008199,GO:0008199,GO:0008284,GO:0009792,GO:0010039,GO:0010722,GO:0016226,GO:0016226,GO:0016540,GO:0018283,GO:0018283,GO:0019230,GO:0030307,GO:0034755,GO:0034986,GO:0034986,GO:0035265,GO:0040015,GO:0043066,GO:0043085,GO:0044571,GO:0044572,GO:0044572,GO:0046621,GO:0046716,GO:0051349,GO:0051349,GO:0051537,GO:0051537,GO:0070301,GO:0090201,GO:0099128,GO:1904231,GO:1904234,GO:1990221,GO:1990229

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FXN hsa:2395 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TP53 FXN 23180781 25158131 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 FXN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC FXN 12695333 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 FXN 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FXN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SRF FXN 20808827 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E0524 FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000017DBB8 FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004AE8D3 FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00005ECFE5 FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004214BB FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000031BC7D FXN 23382970 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004214BB FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002E0524 FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00005ECFE5 FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000017DBB8 FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00004AE8D3 FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000031BC7D FXN 23382970 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000033EBB8 FXN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A405B FXN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002A71AD FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003808EC FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032EF64 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000237CBD FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000B1C9 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000A07C1 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 FXN 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA FXN 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 FXN 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004929F1 FXN 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002373FD FXN 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 FXN 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000CC005 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 FXN 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD FXN 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 FXN 25416803 26717909 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000237E04 FXN 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004900F1 FXN 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000075AB14 FXN 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000041FA2C FXN 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC FXN 22135298 phosphorylation N/A PhosphoSite
CS FXN 25361965 interaction type N/A PTMCode2
FXN CS 25361965 interaction type N/A PTMCode2
CPNE1 FXN 25361965 interaction type N/A PTMCode2
FXN CPNE1 25361965 interaction type N/A PTMCode2
SDHB FXN 25361965 interaction type N/A PTMCode2
FXN SDHB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PICK1 FXN 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ACTN1 FXN 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
FXN PMPCB 14525934 25348397 27898060 9700204 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
FXN LYRM4 25348397 N/A physical interaction ComPPI
FXN RNF126 25348397 N/A physical interaction ComPPI
FXN PASK 21418524 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
FXN SDHA 15961414 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FXN SDHB 15961414 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FXN DAPP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FXN GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FXN ETFRF1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SRC FXN 25948553 27898060 N/A N/A OmniPath

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