Gene Information gene info

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GENE：LCN2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LCN2
FullNmae lipocalin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6526
EnsembleID ENSG00000148346
Uniprot P80188

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LCN2 pyroptosis 38844113 We found that LCN2 effectively regulated pyroptosis events by modulating the NF-κB/NLRP3/GSDMD signaling axis in NCM460 cells stimulated by LPS and ATP. retulator signature
LCN2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LCN2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LCN2 ferroptosis 38871948 Mechanistically, MafG physically interacted with non-muscle myosin heavy chain IIa (MYH9) to transcriptionally activate lipocalin 2 (LCN2) expression, a known suppressor for ferroptosis. retulator signature

Go Annotation:

GeneSymbol Go id
LCN2 GO:0005506,GO:0005506,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0006915,GO:0015891,GO:0034755,GO:0035580,GO:0036094,GO:0042742,GO:0042802,GO:0045087,GO:0070062,GO:0120162,GO:0140315,GO:1903981

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LCN2 hsa:3934 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKBIZ LCN2 17447895 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB1 LCN2 17447895 23180781 physical association anti tag coimmunoprecipitation InnateDB
RELA LCN2 17447895 23180781 physical association anti tag coimmunoprecipitation InnateDB
LRP2 LCN2 15670845 23180781 physical association surface plasmon resonance InnateDB
MMP9 LCN2 17721627 17907186 23180781 physical association anti tag coimmunoprecipitation InnateDB
SLC22A17 LCN2 17253959 23180781 physical association anti tag coimmunoprecipitation InnateDB
CEBPB LCN2 20220144 23180781 physical association electrophoretic mobility supershift assay InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 LCN2 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LCN2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA LCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 LCN2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 LCN2 15536164 19707556 20220144 24391115 trascriptional regulation,stimulation inferred by curator TFlink
NR3C2 LCN2 22469622 trascriptional regulation,stimulation inferred by curator TFlink
RELA LCN2 15536164 19707556 20220144 24391115 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 LCN2 24391115 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
MMP2 LCN2 25361965 interaction type N/A PTMCode2
LCN2 MMP2 25361965 interaction type N/A PTMCode2
LCN2 MMP9 25361965 interaction type N/A PTMCode2
MMP9 LCN2 25361965 interaction type N/A PTMCode2
LRP2 LCN2 25361965 interaction type N/A PTMCode2
LCN2 LRP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TBC1D22B LCN2 25348397 N/A physical interaction ComPPI
PDE4DIP LCN2 25348397 N/A physical interaction ComPPI
ZBED1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TXN2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKAA2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CTDSP2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBASH3A LCN2 25348397 N/A two hybrid ComPPI
SGTA LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MYDGF LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTB LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SEC61G LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHIC2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRIM32 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PICK1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZIC1 LCN2 25348397 N/A physical interaction ComPPI
ITGA9 LCN2 25348397 N/A physical interaction ComPPI
P4HB LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
XRN2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PDIA4 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBQLN2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TRH LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EHHADH LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSG101 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAMP2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NPPA LCN2 25348397 N/A physical interaction ComPPI
UBQLN1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CAMLG LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
POU4F2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMF LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NEIL2 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LY96 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX19B LCN2 25348397 N/A physical interaction ComPPI
MMP2 LCN2 14525934 25348397 27898060 7683678 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
MMP9 LCN2 10339412 1281792 14525934 17721627 17907186 18077379 24234451 25348397 27898060 physical association experimental interaction detection,physical interaction,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD,IntAct,OmniPath
CCNC LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 KIR3DS1 25348397 N/A physical interaction ComPPI
LCN2 UGT1A10 25348397 N/A physical interaction ComPPI
LCN2 L2HGDH 25348397 N/A physical interaction ComPPI
LCN2 HNRNPA1 25348397 N/A physical interaction ComPPI
LCN2 DDX31 25348397 N/A physical interaction ComPPI
LCN2 SINHCAF 25348397 N/A physical interaction ComPPI
LCN2 SNX27 25348397 N/A physical interaction ComPPI
LCN2 RNF25 25348397 N/A physical interaction ComPPI
LCN2 GID8 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
LCN2 URM1 21209336 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LCN2 BEX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 UBE2F 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 URB1-AS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 ALKBH4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 TRIAP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 SCNM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 MAGED4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 TBC1D21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 CLMP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 ASB10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 ODAPH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 LAIR2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 VEZF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 C20ORF85 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 HDDC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 FAM25C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HGF LCN2 14525934 15637066 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PELI1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PTRH1 LCN2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
LCN2 LCN2 14525934 24234451 7683678 8633182 physical association experimental interaction detection,two hybrid array,two hybrid prey pooling approach HPRD,IntAct
LRP2 LCN2 14525934 15670845 27898060 N/A experimental interaction detection HPRD,OmniPath
LCN2 SLC22A17 17253959 27898060 N/A N/A OmniPath

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