GENE：MT2A
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MT2A |
| FullNmae | metallothionein 2A |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7406 |
| EnsembleID | ENSG00000125148 |
| Uniprot | P02795 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MT2A | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| MT2A | ferroptosis | 38657513 | Knockdown of MT2A restored the aberrant activation of the MAPK signaling pathway, elevated antioxidant capacity, ferroptosis inhibition, and ultimately the development of malignant phenotypes that induced by 4-NP in the transformed cells. | retulator signature |
| MT2A | cuproptosis | 38613350 | First, a 10-cuproptosis-related gene signature (ADAM9, ADAM17, ALB, AQP1, CDK1, MT2A, PAM, SOD3, STEAP3, and TMPRSS6) displayed excellent predictive performance for the overall survival of cholangiocarcinoma. | retulator signature |
| MT2A | cuproptosis | 38408075 | We retrieved 21 genes involved in Cuproptosis from the literature, including CDKN2A, DLD, DLAT, FDX1, GLS, LIAS, LIPT1, MTF1, PDHA1, and PDHB, ATB7B, CUTC, GRX1, MT1A, MT2A, MT3, XIAP, ATM, PRNP, P53, and SP1. | genes involved in Cuproptosis |
| MT2A | cuproptosis | 38408075 | We showed the mechanism of action of these genes in Cuproptosis. Excess Cu2+ stimulates the activation of ATM which activates SP1 and P53. P53 promotes PRNP, MT1A, MT2A and MT3A to expel Cu2+ out of the cell. | suppressor |
| MT2A | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| MT2A | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.16 database. |
| MT2A | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.36 database. |
| MT2A | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| MT2A | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MT2A | GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0006878,GO:0006882,GO:0008270,GO:0010273,GO:0036016,GO:0036018,GO:0045926,GO:0046872,GO:0071276,GO:0071280,GO:0071294,GO:0071294 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MT2A | hsa:4502 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MT2A | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | MT2A | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | MT2A | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | MT2A | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AHR | MT2A | 23994556 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | MT2A | 11409902 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | MT2A | 11409902 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001CC864 | MT2A | 23553990 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00000157F5 | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C3AC1 | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000077AED | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000045DBD | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | MT2A | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKD1 | MT2A | 14525934 14550308 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,beta galactosidase complementation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,confocal microscopy,two hybrid | ComPPI,HPRD,IntAct |
| PAXIP1 | MT2A | 25348397 | N/A | physical interaction | ComPPI |
| TNS2 | MT2A | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ECT2 | MT2A | 25348397 | N/A | physical interaction | ComPPI |
| RIN3 | MT2A | 24234451 25348397 25814554 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ARF6 | MT2A | 25348397 | N/A | physical interaction | ComPPI |
| NEDD4L | MT2A | 25348397 | N/A | physical interaction | ComPPI |
| RCHY1 | MT2A | 21988832 24234451 25348397 | colocalization,physical association | two hybrid,physical interaction,confocal microscopy | ComPPI,IntAct |
| TFAP2C | MT2A | 24234451 24835590 25348397 | physical association | two hybrid | ComPPI,IntAct |
| BARD1 | MT2A | 25348397 | N/A | physical interaction | ComPPI |
| ADAMTS4 | MT2A | 14525934 16099106 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| MT2A | USP25 | 25348397 | N/A | physical interaction | ComPPI |
| MT2A | LAMTOR5 | 25348397 | N/A | physical interaction | ComPPI |
| MT2A | MCPH1 | 25348397 | N/A | physical interaction | ComPPI |
| SHBG | MT2A | 14525934 15862967 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| AR | MT2A | 17721441 27898060 | stimulant | N/A | OmniPath |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00009B8B61 | MT2A | 27087310 | direct interaction,inhibition | N/A | NPInter |