GENE：P2RX7
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | P2RX7 |
| FullNmae | purinergic receptor P2X 7 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8537 |
| EnsembleID | ENSG00000089041 |
| Uniprot | Q99572 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| P2RX7 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| P2RX7 | lysosomal_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| P2RX7 | immunogenic | 37275552 | To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. | retulator signature |
| P2RX7 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| P2RX7 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| P2RX7 | GO:0000165,GO:0000902,GO:0001530,GO:0001614,GO:0001845,GO:0001913,GO:0001916,GO:0001934,GO:0002028,GO:0002931,GO:0004931,GO:0004931,GO:0005102,GO:0005515,GO:0005524,GO:0005737,GO:0005739,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0006509,GO:0006649,GO:0006900,GO:0006954,GO:0007005,GO:0007166,GO:0007166,GO:0009306,GO:0009410,GO:0009612,GO:0009897,GO:0010043,GO:0010524,GO:0010628,GO:0014047,GO:0014049,GO:0014051,GO:0014054,GO:0016020,GO:0016079,GO:0016485,GO:0017121,GO:0019233,GO:0030163,GO:0030501,GO:0031594,GO:0031668,GO:0032059,GO:0032060,GO:0032060,GO:0032308,GO:0032310,GO:0032496,GO:0032730,GO:0032731,GO:0032755,GO:0032963,GO:0033198,GO:0034405,GO:0034767,GO:0035585,GO:0035590,GO:0042098,GO:0042802,GO:0043025,GO:0043029,GO:0043132,GO:0043409,GO:0043410,GO:0045779,GO:0045794,GO:0045821,GO:0046513,GO:0046931,GO:0046931,GO:0048705,GO:0048873,GO:0050714,GO:0050830,GO:0051209,GO:0051495,GO:0051592,GO:0051602,GO:0051709,GO:0051882,GO:0051899,GO:0051901,GO:0060079,GO:0060907,GO:0070231,GO:0070234,GO:0070588,GO:0070588,GO:0071318,GO:0071359,GO:0072593,GO:0097190,GO:0097191,GO:0098793,GO:0098794,GO:1904172 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| P2RX7 | hsa:5027 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| P2RX7 | hsa:5027 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| P2RX7 | hsa:5027 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| P2RX7 | NLRP3 | 20086177 26192618 | interaction type | N/A | ACSN |
| P2RX7 | PYCARD | 20086177 26192618 | interaction type | N/A | ACSN |
| CAMP | P2RX7 | 15067080 23180781 | physical association | competition binding | InnateDB |
| NLRP2 | P2RX7 | 23180781 23625868 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | P2RX7 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | P2RX7 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | P2RX7 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | P2RX7 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | P2RX7 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000016FD1A | P2RX7 | 18682393 \N | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000021D7C8 | P2RX7 | 18682393 \N | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS000021D7C8 | P2RX7 | 18682393 23824327 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS000016FD1A | P2RX7 | 18682393 23824327 24312495 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00001C4762 | P2RX7 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000451A1 | P2RX7 | 22100165 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EE7F0 | P2RX7 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000030F801 | P2RX7 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006DA05 | P2RX7 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000116F83 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040FA88 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003ACE11 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F0C23 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | P2RX7 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PLEKHF2 | P2RX7 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | P2RX7 | 25348397 | N/A | physical interaction | ComPPI |
| EFEMP2 | P2RX7 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ACTB | P2RX7 | 25348397 | N/A | in vivo | ComPPI |
| KRT31 | P2RX7 | 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NCK1 | P2RX7 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| GRB2 | P2RX7 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| CASK | P2RX7 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| SVIL | P2RX7 | 25348397 | N/A | in vivo | ComPPI |
| TRIM27 | P2RX7 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| EFNB3 | P2RX7 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| P2RX7 | PANX1 | 17036048 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| P2RX7 | TM9SF1 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| P2RX7 | ABL1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| P2RX7 | KRT34 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| P2RX7 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| P2RX7 | NOTCH2NLA | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| P2RX7 | HSF2BP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| P2RX7 | ZNF655 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| EMP3 | P2RX7 | 12107182 25348397 27898060 | N/A | in vitro | ComPPI,OmniPath |
| CAMP | P2RX7 | 15067080 27898060 | N/A | N/A | OmniPath |
| P2RX4 | P2RX7 | 17785580 27898060 | N/A | N/A | OmniPath |
| CDK1 | P2RX7 | 11707406 27898060 | N/A | N/A | OmniPath |