GENE：PMAIP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PMAIP1 |
| FullNmae | phorbol-12-myristate-13-acetate-induced protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9108 |
| EnsembleID | ENSG00000141682 |
| Uniprot | Q13794 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PMAIP1 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PMAIP1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PMAIP1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PMAIP1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PMAIP1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PMAIP1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PMAIP1 | GO:0001836,GO:0005515,GO:0005634,GO:0005739,GO:0005739,GO:0005741,GO:0005829,GO:0005829,GO:0006915,GO:0006974,GO:0010498,GO:0010907,GO:0010917,GO:0042149,GO:0043029,GO:0043065,GO:0043065,GO:0043280,GO:0043331,GO:0043517,GO:0046902,GO:0051607,GO:0071456,GO:0072332,GO:0072593,GO:0090200,GO:0090200,GO:0097136,GO:0097193,GO:1902043,GO:1902237,GO:2001244 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PMAIP1 | hsa:5366 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| PMAIP1 | hsa:5366 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PMAIP1 | IRF3 | 16832344 19152337 23180781 | physical association | anti tag coimmunoprecipitation,electrophoretic mobility supershift assay | InnateDB |
| PMAIP1 | IRF7 | 16832344 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| PMAIP1 | CREB1 | 16832344 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| PMAIP1 | POLR2F | 23180781 23994473 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PMAIP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | PMAIP1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | PMAIP1 | 18414489 21878914 22216287 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | PMAIP1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | PMAIP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PMAIP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PMAIP1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PMAIP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PMAIP1 | 14695212 15856024 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATM | PMAIP1 | 20368352 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KLF6 | PMAIP1 | 22718761 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| KLF9 | PMAIP1 | 22144178 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | PMAIP1 | 22216287 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP73 | PMAIP1 | 17700533 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000171525 | PMAIP1 | 22615771 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000171525 | PMAIP1 | 21572407 22615771 25416803 | mrna cleavage,inhibition | clip,miRNA interference luciferase reporter assay | TarBase |
| URS000021D7C8 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000122ED0 | PMAIP1 | 19088304 23592263 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS000003ABC4 | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00001C04A2 | PMAIP1 | 20371350 21572407 23446348 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS000035CC3E | PMAIP1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000AA464 | PMAIP1 | 20371350 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS00001597DC | PMAIP1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000041CB9C | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000250A40 | PMAIP1 | 21572407 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031BC7D | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031D186 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FA24D | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000076995 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000367985 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00006AA21F | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000096022 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BA274 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020579D | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001383CF | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ECFE5 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C28B2 | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016E46F | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001BCAC5 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000299AD8 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C7662 | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C02E4 | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000020CEC2 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C85C7 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012A1DD | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000055BBE5 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CD810 | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | PMAIP1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B341F | PMAIP1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000330617 | PMAIP1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004959F4 | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018C928 | PMAIP1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000236310 | PMAIP1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EE123 | PMAIP1 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C5BAA | PMAIP1 | 20371350 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001EFBE3 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000050CCE0 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004214BB | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AAA0 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F4AC3 | PMAIP1 | 20371350 21572407 23446348 24488097 25416803 | mrna cleavage,inhibition | experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay | TarBase |
| URS00003D8730 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272039 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | PMAIP1 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F7766 | PMAIP1 | 20371350 21572407 22012620 23446348 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001941B8 | PMAIP1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CAE0C | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | PMAIP1 | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000211070 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010F787 | PMAIP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000034979B | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000018E72A | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000039D790 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | PMAIP1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CDK5 | PMAIP1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| BCL2L1 | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | BCL2L1 | 25361965 | interaction type | N/A | PTMCode2 |
| BAX | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | BAX | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | BCL2 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2 | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | MCL1 | 25361965 | interaction type | N/A | PTMCode2 |
| MCL1 | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| BCL2L2 | PMAIP1 | 25361965 | interaction type | N/A | PTMCode2 |
| PMAIP1 | BCL2L2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CUL5 | PMAIP1 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2L11 | PMAIP1 | 23374347 24234451 25348397 | physical association | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BCL2L2 | PMAIP1 | 15694340 24234451 25348397 | N/A | anti tag coimmunoprecipitation,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BCL2L1 | PMAIP1 | 10807576 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD |
| RNF7 | PMAIP1 | 25348397 | N/A | physical interaction | ComPPI |
| GSK3B | PMAIP1 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| MCL1 | PMAIP1 | 14525934 15694340 15901672 16697956 20085765 21132008 21454712 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,surface plasmon resonance,physical interaction,in vitro | ComPPI,HPRD,IntAct |
| ZBTB16 | PMAIP1 | 14525934 16169070 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| HUWE1 | PMAIP1 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2A1 | PMAIP1 | 14525934 15694340 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| UCHL1 | PMAIP1 | 25348397 | N/A | physical interaction | ComPPI |
| BCL2 | PMAIP1 | 10807576 14525934 21454712 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| PMAIP1 | BAX | 14525934 15705586 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| PMAIP1 | PPBP | 14525934 16169070 24234451 25348397 | physical association | two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| PMAIP1 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| PMAIP1 | MED4 | 25348397 | N/A | physical interaction | ComPPI |
| PMAIP1 | MYCN | 24234451 26859456 | association | chromatin immunoprecipitation assay | IntAct |
| CDK5 | PMAIP1 | 21145489 25829494 26411306 27898060 | inhibition | N/A | OmniPath |
| PMAIP1 | BCL2L1 | 10807576 15694340 15721256 15725726 27898060 | inhibition | N/A | OmniPath |
| MYC | PMAIP1 | 15856024 27898060 | inhibition,stimulant | N/A | OmniPath |
| PMAIP1 | BCL2 | 10807576 15694340 15725726 21454712 27898060 | inhibition | N/A | OmniPath |
| PMAIP1 | GMCL1 | 15694340 27898060 | inhibition | N/A | OmniPath |
| TRIM28 | PMAIP1 | 17942393 27898060 | inhibition | N/A | OmniPath |
| TP53 | PMAIP1 | 10807576 27898060 | stimulant | N/A | OmniPath |
| PMAIP1 | MCL1 | 15694340 15721256 15901672 16697956 19148187 21139584 21353614 21454712 21613222 22219388 22361683 23341456 27898060 | inhibition | N/A | OmniPath |
| PMAIP1 | BCL2A1 | 15694340 27898060 | inhibition | N/A | OmniPath |
| AR | PMAIP1 | 17721441 27898060 | stimulant | N/A | OmniPath |
| PMAIP1 | BAX | 15705586 27898060 | stimulant | N/A | OmniPath |