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GENE：S100A8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol S100A8
FullNmae S100 calcium binding protein A8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10498
EnsembleID ENSG00000143546
Uniprot P05109

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
S100A8 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
S100A8 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
S100A8 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
S100A8 GO:0002523,GO:0002523,GO:0002544,GO:0002790,GO:0002793,GO:0005509,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0006914,GO:0006915,GO:0006919,GO:0006954,GO:0008017,GO:0008270,GO:0010043,GO:0014002,GO:0018119,GO:0030307,GO:0030593,GO:0030593,GO:0032119,GO:0032496,GO:0034774,GO:0035425,GO:0035662,GO:0042742,GO:0045087,GO:0045111,GO:0045471,GO:0048306,GO:0050544,GO:0050729,GO:0050786,GO:0050832,GO:0051092,GO:0051493,GO:0062023,GO:0070062,GO:0070488,GO:0070488,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
S100A8 hsa:6279 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
S100A9 S100A8 10571075 10976885 12553726 12645005 17553524 18802069 18809714 19732719 23180781 23248262 23431180 26192618 interaction type,physical association mass spectrometry studies of complexes,pull down,x-ray crystallography ACSN,InnateDB
STAT3 S100A8 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 26192618 27216177 28186502 7543512 interaction type N/A ACSN
CEACAM3 S100A8 11708798 23180781 physical association anti tag coimmunoprecipitation InnateDB
S100A8 NCF2 15642721 23180781 physical association pull down InnateDB
RAC1 S100A8 15642721 23180781 physical association pull down InnateDB
RAC2 S100A8 15642721 23180781 physical association pull down InnateDB
S100A8 S100A8 10771424 23180781 physical association x-ray crystallography InnateDB
MBD1 S100A8 23180781 24464130 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 S100A8 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C S100A8 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
E2F1 S100A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 S100A8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR S100A8 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA S100A8 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB S100A8 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG S100A8 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 S100A8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 S100A8 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
S100A8 S100A9 25361965 interaction type N/A PTMCode2
S100A9 S100A8 25361965 interaction type N/A PTMCode2
S100A8 EXOSC1 25361965 interaction type N/A PTMCode2
EXOSC1 S100A8 25361965 interaction type N/A PTMCode2
S100A8 EXOSC2 25361965 interaction type N/A PTMCode2
EXOSC2 S100A8 25361965 interaction type N/A PTMCode2
NCF2 S100A8 25361965 interaction type N/A PTMCode2
S100A8 NCF2 25361965 interaction type N/A PTMCode2
EXOSC4 S100A8 25361965 interaction type N/A PTMCode2
S100A8 EXOSC4 25361965 interaction type N/A PTMCode2
S100A8 S100A8 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TBC1D22B S100A8 25348397 N/A physical interaction ComPPI
TFAP4 S100A8 25348397 N/A physical interaction ComPPI
UBASH3B S100A8 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
BAG3 S100A8 25348397 N/A physical interaction ComPPI
CDKN1A S100A8 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBB S100A8 25348397 N/A physical interaction ComPPI
MCM5 S100A8 25348397 N/A physical interaction ComPPI
KEAP1 S100A8 25348397 N/A physical interaction ComPPI
MCM2 S100A8 25348397 N/A physical interaction ComPPI
DDIT4L S100A8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NF2 S100A8 25348397 N/A physical interaction ComPPI
SHC1 S100A8 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
UNC119 S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GRB2 S100A8 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
COPS5 S100A8 25348397 N/A physical interaction ComPPI
PAXIP1 S100A8 25348397 N/A physical interaction ComPPI
GAPDH S100A8 24234451 25348397 25417112 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,fluorescent resonance energy transfer,biochemical ComPPI,IntAct
DLD S100A8 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PRMT1 S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
KSR2 S100A8 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
TUBA4A S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CFTR S100A8 25348397 N/A physical interaction ComPPI
USF2 S100A8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKBIB S100A8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CDK2 S100A8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBA1A S100A8 25348397 N/A physical interaction ComPPI
CEACAM3 S100A8 11708798 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PPP2R2A S100A8 24234451 25348397 28330616 association pull down ComPPI,IntAct
NOS2 S100A8 24234451 25348397 25417112 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
TUBGCP3 S100A8 25348397 N/A physical interaction ComPPI
PTEN S100A8 25348397 N/A physical interaction ComPPI
VCAM1 S100A8 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
NCF2 S100A8 14525934 15642721 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PPM1B S100A8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PPIA S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
BECN1 S100A8 25348397 N/A physical interaction ComPPI
LRIF1 S100A8 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
TRIM25 S100A8 25348397 N/A physical interaction ComPPI
GDF9 S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RIF1 S100A8 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
TERF1 S100A8 25348397 N/A physical interaction ComPPI
POT1 S100A8 25348397 N/A physical interaction ComPPI
ESR1 S100A8 21182205 24234451 25348397 25604459 association cosedimentation through density gradient,physical interaction,tandem affinity purification ComPPI,IntAct
NUAK1 S100A8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K3 S100A8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF3IP1 S100A8 20391533 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TERF2 S100A8 25348397 N/A physical interaction ComPPI
RAB17 S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MOB1A S100A8 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KLC2 S100A8 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A8 ERG28 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A8 IGSF21 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
S100A8 PDCD11 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A8 CHGB 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A8 S100A9 10571075 10976885 12553726 14525934 17553524 20936779 23431180 24234451 25348397 25417112 27898060 9867828 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,genetic,in vitro,two hybrid ComPPI,HPRD,IntAct,OmniPath
S100A8 LRRK1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
S100A8 ASB3 25348397 N/A physical interaction ComPPI
S100A8 TP53 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
S100A8 DMWD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
S100A8 SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
S100A8 SIRT7 25348397 N/A physical interaction ComPPI
S100A8 APP 25348397 N/A physical interaction ComPPI
S100A8 SIRT6 25348397 N/A physical interaction ComPPI
S100A8 SMTNL2 25348397 N/A physical interaction ComPPI
S100A8 DPH6 25348397 N/A physical interaction ComPPI
S100A8 EFHD1 25348397 N/A physical interaction ComPPI
S100A8 CCNYL1 25348397 N/A physical interaction ComPPI
S100A8 CYLD 25348397 N/A physical interaction ComPPI
S100A8 PPP2R2B 19156129 24234451 25348397 association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
S100A8 SLX4 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
S100A8 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ZNF16 S100A8 21874239 24234451 25348397 physical association two hybrid ComPPI,IntAct
S100A8 S100A8 10771424 14525934 N/A experimental interaction detection HPRD
MAPT S100A8 24234451 26402096 association anti bait coimmunoprecipitation IntAct
S100A8 RAC2 15642721 27898060 N/A N/A OmniPath
S100A8 TLR4 17767165 27898060 N/A N/A OmniPath
S100A8 RAC1 15642721 27898060 N/A N/A OmniPath

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