Gene Information gene info

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GENE：TF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TF
FullNmae transferrin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11740
EnsembleID ENSG00000091513
Uniprot P02787

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TF mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TF ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TF ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TF GO:0001895,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005769,GO:0005769,GO:0005770,GO:0005788,GO:0005886,GO:0005905,GO:0006826,GO:0006879,GO:0007015,GO:0008198,GO:0008199,GO:0009925,GO:0009986,GO:0010008,GO:0016324,GO:0019731,GO:0030139,GO:0030316,GO:0030669,GO:0031410,GO:0031647,GO:0031982,GO:0034755,GO:0034756,GO:0034774,GO:0034986,GO:0042327,GO:0045178,GO:0045780,GO:0045893,GO:0048260,GO:0048260,GO:0048471,GO:0055037,GO:0055037,GO:0060395,GO:0070062,GO:0070371,GO:0071281,GO:0072562,GO:1990459,GO:1990459,GO:1990712,GO:2000147

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TF hsa:7018 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
TF hsa:7018 path:hsa04216 Ferroptosis - Homo sapiens (human)
TF hsa:7018 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
TF hsa:7018 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TF HFE 19254567 23180781 physical association anti tag coimmunoprecipitation InnateDB
LGALS3 TF 18263896 23180781 physical association pull down InnateDB
IL7R TF 20167604 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 TF 12459033 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
GATA1 TF 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TF 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A TF 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
TFCP2 TF 20796026 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
TP73 TF 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA TF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
DDIT3 TF 12939601 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 TF 12744731 22119392 trascriptional regulation,stimulation inferred by curator TFlink
RELA TF 12744731 22119392 trascriptional regulation,stimulation inferred by curator TFlink
SP1 TF 8548503 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 TF 8548503 trascriptional regulation,stimulation inferred by curator TFlink
YY1 TF 8548503 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB TF N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPD TF N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TF N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB TF N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC TF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 TF 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000006FDD4 TF 23666757 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
APOA1 TF 25361965 interaction type N/A PTMCode2
TF APOA1 25361965 interaction type N/A PTMCode2
TF ALB 25361965 interaction type N/A PTMCode2
ALB TF 25361965 interaction type N/A PTMCode2
TF CALR 25361965 interaction type N/A PTMCode2
CALR TF 25361965 interaction type N/A PTMCode2
TF GAST 25361965 interaction type N/A PTMCode2
GAST TF 25361965 interaction type N/A PTMCode2
TF CUBN 25361965 interaction type N/A PTMCode2
CUBN TF 25361965 interaction type N/A PTMCode2
TF HFE 25361965 interaction type N/A PTMCode2
HFE TF 25361965 interaction type N/A PTMCode2
TTR TF 25361965 interaction type N/A PTMCode2
TF TTR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TTR TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CA8 TF 25348397 N/A physical interaction ComPPI
TFRC TF 12210842 14525934 14691533 16271884 16354665 20404192 21788477 24234451 25348397 29302006 6268632 physical association classical fluorescence spectroscopy,cosedimentation in solution,electron paramagnetic resonance,experimental interaction detection,fluorescence-activated cell sorting,mass spectrometry studies of complexes,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
CTSL TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IGHG1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SYT17 TF 25348397 N/A physical interaction ComPPI
SH3BP2 TF 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CD81 TF 24234451 25348397 30024968 association anti bait coimmunoprecipitation ComPPI,IntAct
GRB2 TF 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GTF2F2 TF 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
SMAD3 TF 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSMA3 TF 25348397 N/A physical interaction ComPPI
APOA1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CANX TF 14525934 25348397 9312001 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CALR TF 14525934 25348397 9312001 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PPP1CA TF 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
MYC TF 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RYR1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
C3 TF 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CFTR TF 25348397 N/A physical interaction ComPPI
MAPK6 TF 25348397 N/A physical interaction ComPPI
RAB5A TF 25348397 N/A physical interaction ComPPI
FNBP1 TF 25348397 N/A physical interaction ComPPI
TFR2 TF 11027676 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
HFE TF 20618438 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
EDIL3 TF 25348397 N/A physical interaction ComPPI
UPF1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SYT2 TF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TUBB4A TF 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ESR1 TF 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
MATN3 TF 25348397 N/A physical interaction ComPPI
TIMELESS TF 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SORT1 TF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DDX19B TF 25348397 N/A physical interaction ComPPI
MIS12 TF 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
GAST TF 19664057 24234451 25348397 27898060 N/A cross-linking study,surface plasmon resonance,competition binding,surface plasmon resonance array ComPPI,IntAct,OmniPath
IGFBP3 TF 11297622 11749962 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
RMDN3 TF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TYRP1 TF 25348397 N/A physical interaction ComPPI
ALDH2 TF 25348397 N/A physical interaction ComPPI
IGF2 TF 25348397 N/A physical interaction ComPPI
TUBB3 TF 14525934 16169070 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
UTP3 TF 25348397 N/A physical interaction ComPPI
SH2D4A TF 25348397 N/A physical interaction ComPPI
GABARAPL1 TF 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ALB TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
GLRA2 TF 25348397 N/A physical interaction ComPPI
URM1 TF 21209336 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SNX27 TF 25348397 N/A physical interaction ComPPI
SLX4 TF 19596235 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
IGKC TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MC1R TF 25348397 N/A physical interaction ComPPI
FN1 TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CCDC82 TF 25348397 N/A physical interaction ComPPI
ERGIC3 TF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF IGF1 25348397 N/A physical interaction ComPPI
TF VKORC1 25348397 N/A physical interaction ComPPI
TF LAMC3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TF GDPD1 25348397 N/A physical interaction ComPPI
TF STPG2 25348397 N/A physical interaction ComPPI
TF SLC38A6 25348397 N/A physical interaction ComPPI
TF DDX31 25348397 N/A physical interaction ComPPI
TF IGHA1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF SERPIND1 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF SETX 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF IGKV2D-40 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF KRT72 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TF PGRMC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF CPLX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF HSD17B13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF TMEM52B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF GPR42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF LEUTX 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TF IGHG4 24234451 25348397 physical association inference by socio-affinity scoring ComPPI,IntAct
CUBN TF 11606717 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
TF IGFBP1 11297622 14525934 N/A experimental interaction detection HPRD
TF IGFBP2 11297622 14525934 N/A experimental interaction detection HPRD
TF IGFBP4 11297622 14525934 N/A experimental interaction detection HPRD
TF IGFBP5 11297622 14525934 N/A experimental interaction detection HPRD
TF IGFBP6 11297622 14525934 N/A experimental interaction detection HPRD
TF DRD2 24234451 28298427 physical association ubiquitin reconstruction IntAct
MAPT TF 24234451 26402096 association anti bait coimmunoprecipitation IntAct
IL7R TF 20167604 27898060 N/A N/A OmniPath
TF TFRC 12210842 14691533 16271884 16354665 20404192 21788477 27898060 6268632 6270680 9546397 stimulant N/A OmniPath

Visualization










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