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GENE：TFRC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TFRC
FullNmae transferrin receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11763
EnsembleID ENSG00000072274
Uniprot P02786

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TFRC mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TFRC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TFRC ferroptosis 35821227 We demonstrated that the TFRC gene plays an important role in promoting ferroptosis in CVB3 infection and downregulation of TFRC attenuated the ferroptosis. retulator signature
TFRC ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TFRC GO:0001618,GO:0001666,GO:0001934,GO:0003723,GO:0003725,GO:0004998,GO:0004998,GO:0004998,GO:0005515,GO:0005576,GO:0005615,GO:0005768,GO:0005769,GO:0005886,GO:0005886,GO:0005886,GO:0005905,GO:0006826,GO:0006826,GO:0006879,GO:0006879,GO:0006953,GO:0007584,GO:0009897,GO:0009897,GO:0009986,GO:0009986,GO:0010008,GO:0010008,GO:0010039,GO:0010042,GO:0010628,GO:0010637,GO:0016020,GO:0016323,GO:0019901,GO:0030316,GO:0030544,GO:0030669,GO:0030890,GO:0031334,GO:0031410,GO:0031623,GO:0032526,GO:0033138,GO:0033572,GO:0033572,GO:0035556,GO:0042102,GO:0042470,GO:0042802,GO:0042803,GO:0043066,GO:0043123,GO:0043231,GO:0044877,GO:0045780,GO:0045830,GO:0046688,GO:0046718,GO:0048471,GO:0051092,GO:0055037,GO:0055038,GO:0070062,GO:0071466,GO:0072562,GO:0150104,GO:1900182,GO:1903561,GO:1990712,GO:1990830

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TFRC hsa:7037 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
TFRC hsa:7037 path:hsa04144 Endocytosis - Homo sapiens (human)
TFRC hsa:7037 path:hsa04145 Phagosome - Homo sapiens (human)
TFRC hsa:7037 path:hsa04216 Ferroptosis - Homo sapiens (human)
TFRC hsa:7037 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
TFRC hsa:7037 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACAP1 TFRC 16256741 23180781 physical association affinity chromatography technology InnateDB
HFE TFRC 19254567 23180781 physical association anti tag coimmunoprecipitation InnateDB
LGALS3 TFRC 16393961 23180781 physical association pull down InnateDB
RNF2 TFRC 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 TFRC 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TFRC 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TFRC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TFRC 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC TFRC 12695333 16466700 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 TFRC 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A TFRC 10446187 10446188 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TFRC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VHL TFRC 15985433 trascriptional regulation,stimulation inferred by curator TFlink
YY1 TFRC 19437620 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 TFRC N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 TFRC N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN TFRC N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 TFRC N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000096022 TFRC 19135902 rna interference,inhibition northern blot,miRNA interference luciferase reporter assay miRSponge
URS00003CF1AD TFRC 18523662 19135902 19164563 rna interference,inhibition experimental interaction detection,northern blot,miRNA interference luciferase reporter assay miRSponge
URS00003CF1AD TFRC 18523662 19135902 19164563 25416803 mrna cleavage,inhibition experimental interaction detection,northern blot,miRNA interference luciferase reporter assay TarBase
URS0000096022 TFRC 19135902 25416803 mrna cleavage,inhibition experimental interaction detection,northern blot,miRNA interference luciferase reporter assay TarBase
URS000008DA94 TFRC 19135902 25416803 mrna cleavage,inhibition northern blot TarBase
URS000055128B TFRC 22473208 22896707 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00000EED18 TFRC 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00004E008F TFRC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001F0C23 TFRC 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C0FCB TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC379 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001D69F6 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 TFRC 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000202460 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002F74F1 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000ED600 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000004BACE TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000047944F TFRC 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000166778 TFRC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 TFRC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 TFRC 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 TFRC 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 TFRC 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC TFRC 22135298 phosphorylation N/A PhosphoSite
PRKCA TFRC 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 TFRC 25348397 N/A physical interaction ComPPI
SGTA TFRC 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TFRC RAB5B 14525934 25348397 27898060 7789520 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
TFRC CD247 14525934 25348397 27898060 9448136 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
TFRC HFE 14525934 15965644 20618438 24234451 25348397 9465039 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
TFRC RANBP9 14525934 14722085 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
TFRC GABARAP 11997026 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TFRC ACAP1 14525934 15525538 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TFRC CD4 14525934 14705953 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
TFRC TF 12210842 14525934 14691533 16271884 16354665 20404192 21788477 24234451 25348397 29302006 6268632 physical association classical fluorescence spectroscopy,cosedimentation in solution,electron paramagnetic resonance,experimental interaction detection,fluorescence-activated cell sorting,mass spectrometry studies of complexes,molecular sieving,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array ComPPI,HPRD,IntAct
TFRC SVIP 25348397 N/A physical interaction ComPPI
TFRC PXK 25348397 N/A physical interaction ComPPI
TFRC RYK 25348397 N/A physical interaction ComPPI
TFRC BST2 25348397 N/A physical interaction ComPPI
TFRC HDAC5 25348397 N/A physical interaction ComPPI
TFRC LAPTM4A 25348397 N/A physical interaction ComPPI
TFRC LAPTM4B 25348397 N/A physical interaction ComPPI
TFRC OPTN 25348397 N/A physical interaction ComPPI
TFRC RAB8A 22854040 24234451 25348397 colocalization,physical association pull down,physical interaction,confocal microscopy ComPPI,IntAct
TFRC HGS 25348397 N/A physical interaction ComPPI
TFRC PRKN 25348397 N/A physical interaction ComPPI
TFRC SH3BP4 16325581 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,surface plasmon resonance,physical interaction,competition binding ComPPI,IntAct
TFRC KCNA3 25348397 N/A physical interaction ComPPI
TFRC KCNA5 25348397 N/A physical interaction ComPPI
TFRC FBXO6 25348397 N/A physical interaction ComPPI
TFRC ATP6V1B1 25348397 N/A physical interaction ComPPI
TFRC ESR1 21182205 24234451 25348397 association affinity chromatography technology,cosedimentation through density gradient,physical interaction ComPPI,IntAct
TFRC B4GALT1 25348397 N/A physical interaction ComPPI
TFRC FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TFRC VCAM1 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TFRC ATF2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC ITGA4 25348397 N/A physical interaction ComPPI
TFRC MYO1G 19968988 24234451 25348397 colocalization cosedimentation through density gradient,physical interaction ComPPI,IntAct
TFRC MARCHF8 25348397 N/A physical interaction ComPPI
TFRC CLN3 25348397 N/A physical interaction ComPPI
TFRC ADRB2 25348397 N/A physical interaction ComPPI
TFRC RPA1 25348397 N/A physical interaction ComPPI
TFRC RPA2 25348397 N/A physical interaction ComPPI
TFRC RPA3 25348397 N/A physical interaction ComPPI
TFRC ASB4 25348397 N/A physical interaction ComPPI
TFRC LGR4 25348397 N/A physical interaction ComPPI
TFRC TP53 25348397 N/A physical interaction ComPPI
TFRC HUWE1 25348397 N/A physical interaction ComPPI
TFRC CAV1 25348397 N/A physical interaction ComPPI
TFRC MDM2 25348397 N/A physical interaction ComPPI
TFRC CUL7 25348397 N/A physical interaction ComPPI
TFRC RNF2 25348397 N/A physical interaction ComPPI
TFRC EGFR 25348397 N/A physical interaction ComPPI
TFRC ZFP36 25348397 N/A physical interaction ComPPI
TFRC DLK1 25348397 N/A physical interaction ComPPI
TFRC NTRK1 25348397 N/A physical interaction ComPPI
TFRC TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFRC RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFRC POC5 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFRC TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFRC TMEM216 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TFRC AHSA1 25348397 N/A physical interaction ComPPI
TFRC ERBB2 24189400 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
TFRC GJB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC PDGFRA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC RAB5C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC RAB7A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC ATP6AP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TFRC ARFGAP1 25348397 N/A physical interaction ComPPI
TFRC AP2B1 25348397 N/A physical interaction ComPPI
TFRC SENP3 25348397 N/A physical interaction ComPPI
TFRC ESRRB 25348397 N/A physical interaction ComPPI
TFRC COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TFRC PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TFRC TRIM25 25348397 N/A physical interaction ComPPI
TFRC LMNA 25348397 N/A physical interaction ComPPI
TFRC BRCA1 25348397 N/A physical interaction ComPPI
TFRC TES 25348397 N/A physical interaction ComPPI
TFRC FTH1 20133674 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
TFRC B2M 10638746 20133674 24234451 25348397 association,physical association pull down,x-ray crystallography,physical interaction ComPPI,IntAct
TFRC VPS51 25348397 N/A physical interaction,tandem affinity purification ComPPI
TFRC IKBKE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TFRC MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC YWHAZ 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
TFRC ATP6V1A 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
TFRC CD9 23289620 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC ALB 23384347 24234451 25348397 N/A pull down,comigration in gel electrophoresis ComPPI,IntAct
TFRC SPPL2A 23384347 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
TFRC TBC1D14 22613832 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
TFRC ATG9A 22613832 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
TFRC EPS15 23211419 24234451 25348397 physical association proximity ligation assay ComPPI,IntAct
TFRC TBC1D17 22854040 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
TFRC JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC GET1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC FAM210B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC RELL2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC SLC10A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC RMDN3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC GPR152 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC HIBADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC LHFPL5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC SLC30A10 24234451 25348397 26728129 colocalization confocal microscopy ComPPI,IntAct
TFRC SLC30A4 24234451 25348397 26728129 colocalization confocal microscopy ComPPI,IntAct
TFRC SLC30A3 24234451 25348397 26728129 colocalization confocal microscopy ComPPI,IntAct
TFRC PTPRO 24234451 25348397 28330616 association pull down ComPPI,IntAct
TFRC KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
TFRC CD81 24234451 25348397 30024968 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
TFRC PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
TFRC OCRL 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TFRC BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TFRC LAMP1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
TFRC RAB9A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TFRC TGOLN2 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
TRAF6 TFRC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MGST3 TFRC 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TFRC TFRC 10531064 10638746 14525934 14980223 20208545 23384347 24234451 29302006 N/A cosedimentation in solution,experimental interaction detection,molecular sieving,comigration in gel electrophoresis HPRD,IntAct
TFRC POTEA 24234451 30021884 physical association cross-linking study IntAct
TFRC ETV2 24234451 30021884 physical association cross-linking study IntAct
TFRC AFF3 24234451 30021884 physical association cross-linking study IntAct
TFRC ZNF788P 24234451 30021884 physical association cross-linking study IntAct
TFRC ADCY5 24234451 30021884 physical association cross-linking study IntAct
TFRC EIF4A3 24234451 30021884 physical association cross-linking study IntAct
TFRC NPEPL1 24234451 30021884 physical association cross-linking study IntAct
SRC TFRC 21859709 27898060 N/A N/A OmniPath
PRKCA TFRC 27898060 3013873 3119581 3129437 N/A N/A OmniPath
MAPK1 TFRC 27898060 3013873 3119581 N/A N/A OmniPath
TF TFRC 12210842 14691533 16271884 16354665 20404192 21788477 27898060 6268632 6270680 9546397 stimulant N/A OmniPath
SH3BP4 TFRC 16325581 27898060 inhibition N/A OmniPath

Visualization










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