Gene Information gene info

  1. Home

GENE：ATP7B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ATP7B
FullNmae ATPase copper transporting beta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:870
EnsembleID ENSG00000123191
Uniprot P35670

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ATP7B mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ATP7B cuproptosis 37279744 Nine cuproptosis-related genes were differentially expressed between the severe CAP group and the control group: ATP7B, DBT, DLAT, DLD, FDX1, GCSH, LIAS, LIPT1, and SLC31A1. retulator signature
ATP7B cuproptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
ATP7B cuproptosis 36882769 Through the function of ATPase copper transporting beta (ATP7B), excess copper is excreted into the bile and leaves the body. copper transport
ATP7B cuproptosis 36882769 The entry and departure of copper ions into and out of the cell are controlled by the copper ion transporters SLC31A1 and ATP7B, whereas the transit of copper ions through the outer and inner mitochondrial membranes is controlled by COX17 and SLC25A3, respectively. transporters
ATP7B cuproptosis 36882769 ATPases, including ATP7A and ATP8B, associated with the extracellular excretion of copper, export Cu ions bound to metal binding sites in the presence of ATP. export Cu ions
ATP7B cuproptosis 36882769 knock out lead to intracellular copper accumulation Driver
ATP7B cuproptosis 38408075 ATP7B and GRX1 excrete excess copper ions out of the mitochondria. CUTC directly binds Cu2+ while XIAP passivates and hydrolyzes caspase after binding Cu2+ to inhibit Cuproptosis. suppressor
ATP7B cuproptosis 38168558 Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). copper transporters
ATP7B cuproptosis 38495196 Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. 63 cuproptosis-related genes
ATP7B cuproptosis 38348451 Encode copper transport proteins located on the cell membrane CRGs in the cuproptosis pathway
ATP7B cuproptosis 35964468 Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.40 database.
ATP7B cuproptosis 36313717 The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. Genes related to copper homeostasis pathway
ATP7B cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes
ATP7B cuproptosis 36211378 Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) 43 cuproptosis-related genes in the study
ATP7B cuproptosis 36118866 Inhibitor cuproptosis gene
ATP7B cuproptosis 36685880 A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. cuproptosis-related genes
ATP7B cuproptosis 36568423 Additionally, 41 cuproptosis regulators were obtained from the previous publications. cuproptosis-related genes
ATP7B cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes
ATP7B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ATP7B GO:0000139,GO:0005375,GO:0005507,GO:0005507,GO:0005515,GO:0005524,GO:0005739,GO:0005770,GO:0005794,GO:0005802,GO:0005886,GO:0005886,GO:0006825,GO:0006825,GO:0006825,GO:0006878,GO:0006878,GO:0006882,GO:0007595,GO:0015677,GO:0015677,GO:0015680,GO:0016020,GO:0016323,GO:0016887,GO:0031410,GO:0032588,GO:0034220,GO:0043682,GO:0043682,GO:0043682,GO:0043682,GO:0046688,GO:0048471,GO:0051208,GO:0051649,GO:0060003,GO:0140581,GO:1990961

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ATP7B hsa:540 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
ATP7B hsa:540 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 ATP7B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ATP7B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ATP7B 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 ATP7B 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 ATP7B 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00005D986D ATP7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 ATP7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 ATP7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 ATP7B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F ATP7B 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
CLU ATP7B 21242307 22130675 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DNAJB2 ATP7B 25348397 N/A physical interaction ComPPI
GLRX ATP7B 25348397 N/A physical interaction ComPPI
ZBTB16 ATP7B 14525934 16676348 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
ATOX1 ATP7B 10497213 10557326 12763797 12968035 14525934 16573520 17919502 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
COMMD1 ATP7B 12968035 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ELAVL1 ATP7B 25348397 N/A physical interaction ComPPI
ATP7B DCTN4 14525934 16554302 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
ATP7B HP 25348397 N/A physical interaction ComPPI
ATP7B NRG1 25348397 N/A physical interaction ComPPI
ATP7B CLEC2D 25348397 N/A physical interaction ComPPI
ATP7B ITM2A 25348397 N/A physical interaction ComPPI
ATP7B NTRK3 25348397 N/A physical interaction ComPPI
ATP7B TGOLN2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct

Visualization










  Return