Gene Information gene info

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GENE：SMAD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SMAD4
FullNmae SMAD family member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6770
EnsembleID ENSG00000141646
Uniprot Q13485

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SMAD4 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD4 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD4 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SMAD4 apoptosis 36281726 Further investigations showed that SMAD4 could inhibit osteoblast apoptosis. retulator signature

Go Annotation:

GeneSymbol Go id
SMAD4 GO:0000122,GO:0000785,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001222,GO:0001223,GO:0001228,GO:0001541,GO:0001649,GO:0001658,GO:0001666,GO:0001701,GO:0001702,GO:0001837,GO:0003148,GO:0003161,GO:0003190,GO:0003198,GO:0003220,GO:0003251,GO:0003360,GO:0003677,GO:0003682,GO:0003700,GO:0005515,GO:0005518,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0005667,GO:0005737,GO:0005813,GO:0005829,GO:0005829,GO:0006351,GO:0006357,GO:0006366,GO:0006879,GO:0007179,GO:0007179,GO:0007179,GO:0007179,GO:0007283,GO:0007338,GO:0007411,GO:0008285,GO:0009653,GO:0010614,GO:0010631,GO:0010666,GO:0010718,GO:0014033,GO:0014898,GO:0017015,GO:0030154,GO:0030308,GO:0030325,GO:0030509,GO:0030509,GO:0030509,GO:0030511,GO:0030513,GO:0031005,GO:0032444,GO:0032525,GO:0032909,GO:0032924,GO:0033686,GO:0035556,GO:0036302,GO:0042118,GO:0042177,GO:0042733,GO:0042802,GO:0042803,GO:0043199,GO:0043565,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0046872,GO:0046881,GO:0048382,GO:0048589,GO:0048663,GO:0048733,GO:0048859,GO:0051797,GO:0060065,GO:0060391,GO:0060395,GO:0060395,GO:0060412,GO:0060956,GO:0061040,GO:0061629,GO:0062009,GO:0070102,GO:0070371,GO:0070373,GO:0070411,GO:0070411,GO:0070412,GO:0071141,GO:0071141,GO:0071144,GO:0071144,GO:0071333,GO:0071559,GO:0071773,GO:0072133,GO:0072134,GO:0072520,GO:1901522,GO:1902895,GO:1905305

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SMAD4 hsa:4089 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04110 Cell cycle - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04520 Adherens junction - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05161 Hepatitis B - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05200 Pathways in cancer - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05210 Colorectal cancer - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
SMAD4 hsa:4089 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD4 SMAD2 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 26192618 6357187 8515656 8871614 9312026 9389648 9618481 9670020 association N/A ACSN
SMAD4 SMAD3 10092624 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11486006 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17591701 17689680 17705132 18353785 18729074 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23180781 23338822 23390297 23784029 23869868 25374926 26192618 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020 association,physical association anti tag coimmunoprecipitation,gst pull down,electrophoretic mobility supershift assay,tandem affinity purification ACSN,InnateDB
SMAD4 SNAI1 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16179589 16510505 16617148 16713975 16831886 17018611 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18768831 18832382 19208835 19412634 19597490 20731704 21041997 21042762 21199805 21317430 21577210 21614932 21883379 22006115 22331441 22406545 22514743 22945800 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 SP1 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 26192618 8515656 9312026 9389648 9618481 9670020 interaction type N/A ACSN
SMAD4 HMGA2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
SMAD4 ZEB1 11074002 11279127 11792802 12490555 12702545 12743038 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 19839049 20519943 20731704 21199805 21224848 21317430 21614932 21883379 22006115 22406545 225147423 22945800 26192618 9389648 interaction type N/A ACSN
SMAD4 ATF3 11074002 11170475 11279127 11792802 12490555 12702545 12718878 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 23850759 26192618 8893010 9389648 9865696 interaction type N/A ACSN
SMAD4 ACTA2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 FAP 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD7 SMAD4 11279127 15265520 19032343 23180781 23784029 26192618 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
SMAD4 TIMP1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 TNC 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 ITGB5 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 SPP1 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 26192618 8515656 9312026 9389648 9618481 9670020 interaction type N/A ACSN
SMAD4 ETS1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 ITGA11 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 26192618 9389648 9670020 interaction type N/A ACSN
SMAD4 FGF2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 GLI1 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 GLI2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 POSTN 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 26192618 9389648 9670020 interaction type N/A ACSN
SMAD4 NOX4 11074002 11279127 11792802 12702545 12809600 15265520 16179589 16713975 21042762 21614932 22331441 23784029 26192618 9389648 9670020 interaction type N/A ACSN
SMAD4 PTP4A3 11074002 11279127 11792802 12702545 12809600 15265520 16713975 18471976 20609352 21053359 21084277 21614932 21811102 22073279 22970020 23178297 24403062 25139404 26192618 27222233 27526109 9389648 interaction type N/A ACSN
SMAD4 SNAI2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
SMAD4 ZEB2 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
SMAD4 TWIST1 11074002 11279127 11792802 12490555 12702545 12809600 14623871 15265520 16510505 16617148 16713975 16831886 17093497 17403902 17490644 17550342 17563753 17671186 18297062 18832382 19208835 19412634 20731704 21199805 21317430 21614932 21883379 22006115 22406545 22945800 26192618 9389648 interaction type N/A ACSN
SMAD4 NOS2 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD4 IFNG 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
SMAD4 IRF3 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 14729983 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23180781 23390297 26192618 6357187 8515656 8871614 9389648 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
SMAD4 TBX21 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 26192618 6357187 8515656 8871614 9389648 interaction type N/A ACSN
TGFBR1 SMAD4 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330 26192618 interaction type N/A ACSN
TGFBR2 SMAD4 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330 26192618 interaction type N/A ACSN
SMAD4 SQSTM1 15761153 23180781 physical association luminescence based mammalian interactome mapping InnateDB
SMAD4 ATF2 10085140 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
SMAD2 SMAD4 10531362 10878024 11027280 11274206 12167862 12794086 12808092 12957874 15231748 15350224 15613484 15817471 17272273 17591701 18511908 18729074 18783722 18988627 19135894 21071413 21454478 21532621 23180781 23331499 9288972 stimulation,physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB,SignaLink,SignaLink
SMAD4 WWP1 15946939 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 BTRC 15855639 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 VEGFA 11486006 18952601 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
SMAD4 HIF1A 11486006 23180781 physical association electrophoretic mobility supershift assay InnateDB
SMAD4 ARNT 11486006 23180781 physical association electrophoretic mobility supershift assay InnateDB
SMAD4 IRF7 14729983 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 COL1A1 19558215 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,nucleic acid uv cross-linking assay InnateDB
SMAD4 ZFYVE9 15613484 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 ACHE 19468687 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
SMAD4 NOTCH4 16007227 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 SMAD4 10092624 14647410 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD4 SKI 12764135 19032343 23180781 physical association anti tag coimmunoprecipitation,tandem affinity purification InnateDB
SMAD4 SKIL 12764135 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 SERPINE1 10092624 19139564 23180781 9606191 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
SMAD4 SKOR2 19934318 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 FHL1 19139564 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD4 FHL2 19139564 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD4 FHL3 19139564 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD4 CDKN1A 19139564 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 MYC 19139564 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 TTK 17452325 23180781 physical association tandem affinity purification InnateDB
SMAD4 ZFYVE16 17272273 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 KLF5 19419955 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
SMAD4 CDKN2B 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
EP300 SMAD4 19419955 21269274 22033265 23180781 23331499 9679056 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
SMAD4 ID1 20206131 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 ITGB7 12606711 23180781 physical association pull down InnateDB
SMAD4 GATA2 20211142 23180781 physical association pull down InnateDB
ISG15 SMAD4 16009940 23180781 physical association unspecified method InnateDB
NLK SMAD4 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
GATA2 SMAD4 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 UBE2I 21988832 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD4 CREB1 23331499 9689110 stimulation N/A SignaLink,SignaLink
SMAD4 LEF1 10890911 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD4 FOS 10942775 23331499 stimulation N/A SignaLink,SignaLink
SKI SMAD4 10531062 12732634 12793438 12874272 14525983 14699069 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD3 SMAD4 10531362 10878024 10995777 12794086 12957874 15231748 15350224 18988627 19135894 21071413 21532621 22045334 23331499 9311995 stimulation N/A SignaLink,SignaLink
SUMO1 SMAD4 12740389 12813045 14514699 21071413 23331499 stimulation N/A SignaLink,SignaLink
SMAD1 SMAD4 10531362 14534577 15231748 15761153 18988627 21071413 21454478 23331499 stimulation N/A SignaLink,SignaLink
HYAL2 SMAD4 20542955 23331499 stimulation N/A SignaLink,SignaLink
WWOX SMAD4 20542955 23331499 stimulation N/A SignaLink,SignaLink
SMAD4 ATF1 10480932 23331499 stimulation N/A SignaLink
SNIP1 SMAD4 10887155 23331499 stimulation N/A SignaLink
XPO1 SMAD4 11074002 23331499 stimulation N/A SignaLink
SMAD4 MEF2A 11160896 23331499 stimulation N/A SignaLink
EIF4E SMAD4 12150994 23331499 stimulation N/A SignaLink
SKIL SMAD4 10531062 12793438 23331499 stimulation N/A SignaLink
PIAS4 SMAD4 12904571 23331499 stimulation N/A SignaLink
NUP214 SMAD4 12917407 23331499 stimulation N/A SignaLink
NUP153 SMAD4 12917407 23331499 stimulation N/A SignaLink
SMAD5 SMAD4 10531362 14534577 15231748 23331499 stimulation N/A SignaLink
FBXW11 SMAD4 14988407 23331499 stimulation N/A SignaLink
PIAS1 SMAD4 15028714 15231748 23331499 stimulation N/A SignaLink
TRIM33 SMAD4 15820681 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SMAD4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SMAD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SMAD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SMAD4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
DMTF1 SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
SRF SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
ZEB1 SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
NRF1 SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
BPTF SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
TP53 SMAD4 21421563 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SMAD4 11854297 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SMAD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GLI1 SMAD4 24739390 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 SMAD4 23817620 trascriptional regulation,stimulation inferred by curator TFlink
JUNB SMAD4 11854297 trascriptional regulation,stimulation inferred by curator TFlink
KAT2B SMAD4 19525977 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB SMAD4 N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR1 SMAD4 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN SMAD4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 SMAD4 23393589 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00001EFBE3 SMAD4 21968601 22507670 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS0000338542 SMAD4 21036908 rna interference,inhibition western blot miRSponge
URS00002075FA SMAD4 20940405 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS00001CC379 SMAD4 23226455 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000035CC3E SMAD4 20940405 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000006FDD4 SMAD4 20940405 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS0000184017 SMAD4 20118412 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00001C11BC SMAD4 23393589 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000031602A SMAD4 23393589 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS000003575B SMAD4 21112326 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000003575B SMAD4 21112326 25416803 26747772 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000035CC3E SMAD4 20940405 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002075FA SMAD4 20371350 20940405 21572407 23446348 24220575 25416803 mrna cleavage,inhibition array technology,clip,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 SMAD4 20371350 20940405 21572407 23446348 23998804 24220575 25416803 mrna cleavage,inhibition array technology,clip,miRNA interference luciferase reporter assay TarBase
URS0000042E1F SMAD4 20371350 20940405 21572407 23446348 25416803 27286257 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB SMAD4 21159887 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004505E4 SMAD4 21352803 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001EFBE3 SMAD4 21968601 22020746 22507670 23832538 24939082 25416803 27438138 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000184017 SMAD4 20118412 23922662 25416803 25804630 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001F0C23 SMAD4 22357933 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000315338 SMAD4 20371350 21572407 22942087 23393589 23418453 23446348 25416803 26817584 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001C11BC SMAD4 20371350 21572407 23393589 23446348 25416803 26019136 26640587 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000031602A SMAD4 20371350 21572407 23393589 23446348 24685242 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00001CC379 SMAD4 23226455 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002C0FCB SMAD4 20371350 21572407 23446348 24220575 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip,miRNA interference luciferase reporter assay TarBase
URS0000338542 SMAD4 21036908 25416803 mrna cleavage,inhibition western blot TarBase
URS000021D7C8 SMAD4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000029D9F1 SMAD4 23221074 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000239117 SMAD4 23591200 24504368 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000016914 SMAD4 23800974 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000101787 SMAD4 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00004F4657 SMAD4 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS0000345DEB SMAD4 20371350 23538390 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000039E1E1 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000037D7E5 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 SMAD4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000195F5B SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 SMAD4 20371350 25416803 26077733 28340489 28348487 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS000008931A SMAD4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B SMAD4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 SMAD4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 SMAD4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 SMAD4 20371350 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 SMAD4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 SMAD4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F SMAD4 23824327 25416803 26600197 28370334 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00002E92A8 SMAD4 25416803 26918315 27536132 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CF056 SMAD4 25416803 27418678 28105233 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000001EB3 SMAD4 25416803 26494556 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002CCA6E SMAD4 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000425000 SMAD4 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK11 SMAD4 22135298 phosphorylation N/A PhosphoSite
NLK SMAD4 22135298 phosphorylation N/A PhosphoSite
LEMD3 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 LEMD3 25361965 interaction type N/A PTMCode2
BMPR1B SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BMPR1B 25361965 interaction type N/A PTMCode2
ACVR1C SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ACVR1C 25361965 interaction type N/A PTMCode2
MAPK1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 MAPK1 25361965 interaction type N/A PTMCode2
BMP4 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BMP4 25361965 interaction type N/A PTMCode2
ATF2 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ATF2 25361965 interaction type N/A PTMCode2
TOB1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TOB1 25361965 interaction type N/A PTMCode2
STK11IP SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 STK11IP 25361965 interaction type N/A PTMCode2
HRAS SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 HRAS 25361965 interaction type N/A PTMCode2
FSTL3 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 FSTL3 25361965 interaction type N/A PTMCode2
TRAP1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TRAP1 25361965 interaction type N/A PTMCode2
CEBPB SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 CEBPB 25361965 interaction type N/A PTMCode2
JUND SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 JUND 25361965 interaction type N/A PTMCode2
JUNB SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 JUNB 25361965 interaction type N/A PTMCode2
HNF4A SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 HNF4A 25361965 interaction type N/A PTMCode2
SMAD4 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TRIM33 25361965 interaction type N/A PTMCode2
TRIM33 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 MAX 25361965 interaction type N/A PTMCode2
MAX SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 TGFBR2 25361965 interaction type N/A PTMCode2
TGFBR2 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 DLX1 25361965 interaction type N/A PTMCode2
DLX1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ZNF521 25361965 interaction type N/A PTMCode2
ZNF521 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BTRC 25361965 interaction type N/A PTMCode2
BTRC SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 JUN 25361965 interaction type N/A PTMCode2
JUN SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 FOXO4 25361965 interaction type N/A PTMCode2
FOXO4 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 AR 25361965 interaction type N/A PTMCode2
AR SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 FOXH1 25361965 interaction type N/A PTMCode2
FOXH1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SKI 25361965 interaction type N/A PTMCode2
SKI SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BMP2 25361965 interaction type N/A PTMCode2
BMP2 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 FOXO1 25361965 interaction type N/A PTMCode2
FOXO1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 EID2 25361965 interaction type N/A PTMCode2
EID2 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 CITED1 25361965 interaction type N/A PTMCode2
CITED1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD7 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SMAD7 25361965 interaction type N/A PTMCode2
MYOD1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 MYOD1 25361965 interaction type N/A PTMCode2
SKP2 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SKP2 25361965 interaction type N/A PTMCode2
AKT1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 AKT1 25361965 interaction type N/A PTMCode2
SMAD6 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SMAD6 25361965 interaction type N/A PTMCode2
BMPR1A SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 BMPR1A 25361965 interaction type N/A PTMCode2
HOXC8 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 HOXC8 25361965 interaction type N/A PTMCode2
GSC SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 GSC 25361965 interaction type N/A PTMCode2
SKIL SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 SKIL 25361965 interaction type N/A PTMCode2
ACVR1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ACVR1 25361965 interaction type N/A PTMCode2
STUB1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 STUB1 25361965 interaction type N/A PTMCode2
ACVRL1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ACVRL1 25361965 interaction type N/A PTMCode2
ZNF423 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ZNF423 25361965 interaction type N/A PTMCode2
KPNB1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 KPNB1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LMO4 SMAD4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PIAS2 SMAD4 14514699 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
UBE2I SMAD4 12621041 14525934 15231748 16189514 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid pooling approach,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SNW1 SMAD4 25348397 N/A physical interaction ComPPI
TSSK3 SMAD4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DAXX SMAD4 25348397 N/A physical interaction ComPPI
RSPH14 SMAD4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FHL3 SMAD4 25348397 N/A physical interaction ComPPI
FBP2 SMAD4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CRYAB SMAD4 25348397 N/A physical interaction ComPPI
ISG15 SMAD4 25348397 N/A physical interaction ComPPI
LRATD2 SMAD4 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN1A SMAD4 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
SKIL SMAD4 10531062 14525934 15231748 24234451 25348397 25609649 association,physical association two hybrid,experimental interaction detection,physical interaction,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
S100A14 SMAD4 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 JUN 10220381 14525934 24234451 25348397 25609649 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
SMAD4 JUND 10220381 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 SMAD5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 GLI3 14525934 25348397 9843199 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 TDG 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 MYOD1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 TENM3 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 RFX1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 PSMD11 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 DNAJB2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 DCP1B 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 HMG20A 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 XPO5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 RPL28 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 TCTA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 HDLBP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 CD59 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 RALA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 GPNMB 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 PSG9 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 NELFCD 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 MAPK13 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 TM9SF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 EEF1A1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 ZBED5 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 RMND5B 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 UHRF2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 MAPK1 12801888 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD4 PSG2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 USB1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 SNRNP70 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 SPTBN1 12543979 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 CEBPB 12202226 12524424 14525934 16959612 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD4 FOXO4 14525934 15084259 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD4 CITED1 14525934 25348397 9707553 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMAD4 AR 12226080 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 TFE3 10557285 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 HNF4A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
SMAD4 ACVR1B 14525934 25348397 9892009 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 SMAD2 11274206 12167862 14525934 15231748 15350224 18511908 18729074 19135894 21297662 21532621 21988832 22442258 24234451 25348397 25609649 9389648 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo,tandem affinity purification,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
SMAD4 CAMK2G 25348397 N/A physical interaction,in vivo ComPPI
SMAD4 FOXO3 14525934 15084259 21532621 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD4 SMAD3 10995777 14525934 15231748 15350224 18729074 19135894 21297662 21532621 21597466 21988832 22045334 22442258 24234451 25348397 25609649 25910212 27107012 29997244 9311995 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,proximity ligation assay,two hybrid bait and prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
SMAD4 BTRC 14525934 14988407 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 FOXH1 14525934 25348397 9288972 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 UBE2L3 12794086 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD4 ZNF423 10660046 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 FSTL3 11571638 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SMAD4 DCP1A 15231748 24234451 25348397 25609649 27107012 association,physical association two hybrid,physical interaction,in vitro,in vivo,tandem affinity purification,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
SMAD4 STK11IP 21988832 24234451 25348397 physical association two hybrid,physical interaction,in vivo ComPPI,IntAct
SMAD4 COPS5 11818334 14525934 14993265 24234451 25348397 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
SMAD4 TGFBRAP1 11278302 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 SNIP1 10887155 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 DLX1 14525934 14671321 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SMAD4 PIAS3 14525934 14691252 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 TOB1 11163184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD4 ECSIT 14525934 14633973 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 PIAS1 14525934 15028714 15231748 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
SMAD4 EID2 14525934 14612439 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 ZNF521 14525934 14630787 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 CTNNB1 12000714 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD4 MEF2A 11160896 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD4 AP2B1 25348397 N/A in vivo ComPPI
SMAD4 APBB2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 ARL5B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 BRCA1 14525934 15735739 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 CHEK1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 EIF2AK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 FBXO30 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 FBXO34 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 HDGF 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 ITK 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 NAT8 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 NEK6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 NRAS 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 NUAK2 25348397 N/A in vivo ComPPI
SMAD4 OCLN 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 PAK1 25348397 N/A in vivo ComPPI
SMAD4 PLK4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAB13 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAB25 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAB2B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAB34 25348397 N/A in vivo ComPPI
SMAD4 RAB38 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAB3B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RAC2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RASD2 25348397 N/A in vivo ComPPI
SMAD4 RASL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RHEBL1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RHOD 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RHOG 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RHOJ 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RIPK2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 RRAS2 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 SMAD1 11779505 14525934 15231748 15761153 17183365 24234451 24412244 25348397 9436979 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,experimental interaction detection,molecular sieving,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
SMAD4 SQSTM1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 STK35 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 UBC 22045334 24234451 25348397 physical association anti tag coimmunoprecipitation,in vivo ComPPI,IntAct
SMAD4 UBA52 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 STUB1 14525934 14701756 15708501 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 TGFBR2 14525934 25348397 8774881 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 RBL1 12150994 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 FOXG1 11387330 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 NOTCH4 14525934 16007227 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 EWSR1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SMAD4 SMAD9 16189514 24234451 25348397 25609649 association,physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,tandem affinity purification ComPPI,IntAct
SMAD4 NUP214 12917407 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 ESR1 11555647 12576474 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
SMAD4 PRKAR2A 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 PRKAR1B 14525934 14966294 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 SP1 10878024 11114293 14525934 21297662 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD4 ESR2 11555647 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 EP300 14525934 25348397 9843571 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 CTCF 12099698 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SMAD4 TRAP1 11278302 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMAD4 PKHD1 25348397 N/A two hybrid,in vitro ComPPI
SMAD4 PARD3 12650946 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SMAD4 MEX3B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 UBE2Z 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 PBK 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 SASH3 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 CREBBP 14525934 25348397 9679056 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SMAD4 DVL1 12650946 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 ERBIN 25348397 N/A physical interaction,in vitro ComPPI
SMAD4 PIAS4 12904571 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
SMAD4 AKT1 14525934 16362038 23397142 24234451 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SMAD4 FOXO1 14525934 15084259 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD4 HOXA9 11042172 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD4 HOXC8 10224145 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD4 ZMYM2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 MAX 12551947 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD4 PAPPA2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 CSH1 25348397 N/A two hybrid,two hybrid,physical interaction ComPPI
SMAD4 CSH2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 FBLN1 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 SKI 12419246 12857746 14525934 14525983 15231748 19032343 24234451 25348397 25609649 26977879 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,cosedimentation through density gradient,experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
SMAD4 DVL1P1 25348397 N/A physical interaction ComPPI
SMAD4 MDM4 25348397 N/A physical interaction ComPPI
SMAD4 KPNB1 25348397 N/A physical interaction ComPPI
SMAD4 CEBPA 25348397 N/A physical interaction ComPPI
SMAD4 CEBPD 25348397 N/A physical interaction ComPPI
SMAD4 TGFBR1 14525934 25348397 8774881 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD4 LEF1 10890911 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SMAD4 SMAD6 25348397 N/A physical interaction ComPPI
SMAD4 SKP2 25348397 N/A physical interaction ComPPI
SMAD4 SMAD7 15128733 19032343 24234451 25348397 association physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
SMAD4 SMURF1 25348397 N/A physical interaction ComPPI
SMAD4 GATA2 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 NKX3-2 25348397 N/A physical interaction ComPPI
SMAD4 YY1 25348397 N/A physical interaction ComPPI
SMAD4 MECOM 25348397 N/A physical interaction ComPPI
SMAD4 SUMO1 25348397 N/A physical interaction ComPPI
SMAD4 HDAC1 25348397 N/A physical interaction ComPPI
SMAD4 KDM6B 25348397 N/A physical interaction ComPPI
SMAD4 TRIM33 19135894 20603019 21597466 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAD4 NKX2-5 19736317 24234451 25348397 25609649 association physical interaction,chromatin immunoprecipitation assay,tandem affinity purification ComPPI,IntAct
SMAD4 USP9X 14525934 19135894 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
SMAD4 USP15 25348397 N/A physical interaction ComPPI
SMAD4 DACH1 14525983 24234451 25348397 physical association coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
SMAD4 WWP1 25348397 N/A physical interaction ComPPI
SMAD4 RNF11 25348397 N/A physical interaction ComPPI
SMAD4 HGS 25348397 N/A physical interaction ComPPI
SMAD4 PAX6 25348397 N/A physical interaction ComPPI
SMAD4 EIF4A3 25348397 N/A physical interaction ComPPI
SMAD4 NCBP1 25348397 N/A physical interaction ComPPI
SMAD4 ALYREF 25348397 N/A physical interaction ComPPI
SMAD4 DDX39B 25348397 N/A physical interaction ComPPI
SMAD4 THOC2 25348397 N/A physical interaction ComPPI
SMAD4 THOC5 25348397 N/A physical interaction ComPPI
SMAD4 ZMIZ1 25348397 N/A physical interaction ComPPI
SMAD4 HERC5 25348397 N/A physical interaction ComPPI
SMAD4 EEF1A1P5 25348397 N/A physical interaction ComPPI
SMAD4 ATF7IP 14525934 15231748 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 CNKSR1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 KLF5 25348397 N/A physical interaction ComPPI
SMAD4 IRF7 25348397 N/A physical interaction ComPPI
SMAD4 IRF3 25348397 N/A physical interaction ComPPI
SMAD4 NCOR1 25348397 N/A physical interaction ComPPI
SMAD4 FHL1 25348397 N/A physical interaction ComPPI
SMAD4 FHL2 25348397 N/A physical interaction ComPPI
SMAD4 CSNK1D 25348397 N/A physical interaction ComPPI
SMAD4 TGFB1I1 25348397 N/A physical interaction ComPPI
SMAD4 PLG 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 LPA 25348397 N/A physical interaction ComPPI
SMAD4 SERPINA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAD4 FN1 14525934 15231748 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD4 RELA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 SOX12 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 NR0B2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 CYFIP2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 NLK 21988832 23602568 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,two hybrid array,confocal microscopy,tandem affinity purification ComPPI,IntAct
SMAD4 OTUB1 25348397 N/A physical interaction ComPPI
SMAD4 SMURF2 25348397 N/A physical interaction ComPPI
SMAD4 GLI1 25348397 N/A physical interaction ComPPI
SMAD4 LHX4 25348397 N/A physical interaction ComPPI
SMAD4 SHMT1 25348397 N/A physical interaction ComPPI
SMAD4 ILKAP 25348397 N/A physical interaction ComPPI
SMAD4 NFIA 25348397 N/A physical interaction ComPPI
SMAD4 BCAS3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 BEX1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 DKK3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 GREB1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 IL24 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 LYPD3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 SERPINB5 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 THRSP 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD4 XPO1 25348397 N/A physical interaction ComPPI
SMAD4 NFIX 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD4 NFKB1 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD4 CHAF1B 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
SMAD4 DNMT3L 25348397 N/A physical interaction ComPPI
SMAD4 NANOGP8 25348397 N/A physical interaction ComPPI
SMAD4 NANOG 25348397 N/A physical interaction ComPPI
SMAD4 AHR 25348397 N/A physical interaction ComPPI
SMAD4 TIAF1 25348397 N/A physical interaction ComPPI
SMAD4 TRIM25 25348397 N/A physical interaction ComPPI
SMAD4 USP4 25348397 N/A physical interaction ComPPI
SMAD4 KDM1A 25348397 N/A physical interaction ComPPI
SMAD4 NR2F2 23201680 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
SMAD4 MED15 12167862 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
SMAD4 DLX4 21297662 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct
SMAD4 LAMTOR5 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
SMAD4 CAV1 24211445 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
SMAD4 ALDOB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 BAAT 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 AOPEP 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 MSANTD3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 TSTD2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 CDC14B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 FANCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 HEMGN 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 HRAS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 CCDC180 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 PPP2CB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 SFRP2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 SFRP4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 SHC1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 ZNF189 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 ZNF510 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 PRMT5 19032343 24234451 25348397 association cosedimentation through density gradient ComPPI,IntAct
SMAD4 GLI2 24234451 25348397 25670079 association anti tag coimmunoprecipitation ComPPI,IntAct
SMAD4 PAX8 24234451 25348397 27107012 physical association split luciferase complementation ComPPI,IntAct
SMAD4 ZIC1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMAD4 NFKBID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RASSF5 SMAD4 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
JUNB SMAD4 10220381 14525934 15231748 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PRKG1 SMAD4 19424179 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBB SMAD4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RPS27A SMAD4 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRPF40A SMAD4 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
ZBTB7A SMAD4 25348397 N/A physical interaction ComPPI
ALDOC SMAD4 25348397 N/A physical interaction ComPPI
ATF2 SMAD4 10085140 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PPP3R2 SMAD4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD4 ZNF8 12370310 14525934 N/A experimental interaction detection,two hybrid HPRD
SMAD4 SMAD4 10647180 11224571 14525934 21988832 24234451 25609649 9111321 association,physical association experimental interaction detection,two hybrid array,tandem affinity purification HPRD,IntAct
ARFRP1 SMAD4 14525934 15761153 N/A experimental interaction detection HPRD
TBX6 SMAD4 19736317 24234451 association chromatin immunoprecipitation assay IntAct
TTK SMAD4 17452325 27898060 N/A N/A OmniPath
SMAD4 CREB1 27898060 9689110 stimulant N/A OmniPath
SMAD4 ATF1 10480932 27898060 stimulant N/A OmniPath
USP9X SMAD4 19135894 22298955 27898060 stimulant N/A OmniPath
STK11 SMAD4 20974850 27898060 N/A N/A OmniPath
UBE2E1 SMAD4 12794086 27898060 N/A N/A OmniPath
SMAD1 SMAD4 10531362 11700304 11779505 12167862 12874272 14701756 15231748 15761153 17183365 20957627 21454478 24412244 26555259 27898060 9111321 9436979 stimulant N/A OmniPath
SKP2 SMAD4 15314162 16865698 27898060 inhibition N/A OmniPath
SMAD4 FOS 10942775 27898060 9732876 stimulant N/A OmniPath
MAPK3 SMAD4 12801888 27898060 inhibition,stimulant N/A OmniPath
SMAD4 GNRHR 15561800 27898060 stimulant N/A OmniPath
SMAD5 SMAD4 10531362 15231748 16516194 20957627 27898060 stimulant N/A OmniPath
SMAD4 LEF1 10890911 27898060 stimulant N/A OmniPath
XPO1 SMAD4 11074002 27898060 inhibition,stimulant N/A OmniPath
UBE2I SMAD4 12621041 15231748 15637079 16189514 21988832 27898060 inhibition,stimulant N/A OmniPath
SUMO1 SMAD4 12740389 12813045 14514699 27898060 stimulant N/A OmniPath
SMAD4 MEF2A 11160896 27898060 stimulant N/A OmniPath
SMAD2 SMAD4 10085121 10199400 10531362 10781087 10878024 11027280 11102446 11114293 11264182 11274206 11927552 12167862 12419246 12543979 12621041 12672795 12732634 12794086 12808092 14764653 15231748 15350224 15467747 15613484 15761153 15817471 15922743 16751102 16916642 17272273 17283070 17452626 17591701 18511908 18729074 18783722 19135894 19139564 19917253 21145499 21297662 21454478 21532621 21988832 22442258 23788427 23973329 24157709 24584437 25514493 25609649 26555259 27898060 9111321 9288972 9311995 9346966 9389648 9892009 stimulant N/A OmniPath
EP300 SMAD4 10887155 14612423 18215124 19419955 21269274 22033265 25514493 27898060 9679056 9843571 inhibition,stimulant N/A OmniPath
MAPK1 SMAD4 12801888 27898060 inhibition,stimulant N/A OmniPath
PIAS1 SMAD4 15028714 15231748 1523175 21988832 27898060 stimulant N/A OmniPath
COPS5 SMAD4 11818334 14993265 17583730 24078030 27898060 inhibition,stimulant N/A OmniPath
SMAD4 DAPK1 11740493 27898060 stimulant N/A OmniPath
NLK SMAD4 19690946 21988832 23602568 27898060 inhibition N/A OmniPath
EIF4E SMAD4 12150994 27898060 stimulant N/A OmniPath
BTRC SMAD4 14988407 15314162 15855639 16865698 25373906 26022109 27898060 inhibition N/A OmniPath
PIAS4 SMAD4 12740389 12815042 12904571 27898060 inhibition,stimulant N/A OmniPath
JUN SMAD4 10220381 27898060 9312063 9732876 stimulant N/A OmniPath
SMAD3 SMAD4 10092624 10531362 10878024 10995777 11114293 11927552 12145309 12167862 12419246 12543979 12672795 12732634 12794086 12917407 12957874 14764653 15084259 15231748 15350224 15467747 15588252 15761153 15922743 17226765 17283070 17591701 18729074 19135894 19139564 19768112 19917253 20142324 20564330 21145499 21297662 21532621 21988832 22045334 22310290 22442258 23788427 24157709 24382352 24584437 25514493 25609649 26555259 27898060 9111321 9311995 9843571 9892009 stimulant N/A OmniPath
SMAD9 SMAD4 10583507 15231748 16189514 20957627 25609649 27898060 stimulant N/A OmniPath
UBE2L3 SMAD4 12794086 27898060 N/A N/A OmniPath
SMAD7 SMAD4 10559222 15817471 17438144 26555259 27898060 stimulant N/A OmniPath
SKIL SMAD4 10531062 12764135 12793438 1279344 15231748 15761153 17469184 25059663 25609649 27898060 inhibition,stimulant N/A OmniPath
NUP214 SMAD4 12917407 27898060 stimulant N/A OmniPath
HYAL2 SMAD4 20542955 27898060 stimulant N/A OmniPath
WWOX SMAD4 20542955 27898060 stimulant N/A OmniPath
SMAD6 SMAD4 15817471 22298955 27898060 9256479 inhibition N/A OmniPath
SMURF1 SMAD4 15817471 23973329 27898060 inhibition N/A OmniPath
TRIM33 SMAD4 15820681 19135894 21597466 21726812 23788427 24307592 24382352 27898060 stimulant N/A OmniPath
NUP153 SMAD4 12917407 27898060 stimulant N/A OmniPath
SKI SMAD4 10485843 10531062 12419246 12732634 12764135 12793438 12857746 12874272 14525983 14699069 15231748 15761153 17469184 19032343 20959473 25609649 25670202 27898060 inhibition,stimulant N/A OmniPath
FBXW11 SMAD4 14988407 27898060 stimulant N/A OmniPath
SNIP1 SMAD4 10887155 27898060 inhibition N/A OmniPath

Visualization










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