GENE：CP
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CP |
| FullNmae | ceruloplasmin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2295 |
| EnsembleID | ENSG00000047457 |
| Uniprot | P00450 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CP | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| CP | ferroptosis | 40358211 | Here, we provide evidence that both CP and NCP BVDV can induce ferroptosis in Madin-Darby bovine kidney cells at similar rate. | retulator signature |
| CP | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| CP | cuproptosis | 38006800 | Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C-C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. | retulator signature |
| CP | cuproptosis | 38200525 | Ceruloplasmin (CP) is the main protein carrier used in plasma for the exchange of copper ions [45, 46], which is not only involved in ferroptosis but also in cuproptosis. | Driver |
| CP | cuproptosis | 38006800 | Overall, expression of cuproptosis-related genes (CRGs) CD274, Ceruloplasmin (CP), Vascular endothelial growth factor A (VEGFA), Copper chaperone for cytochrome c oxidase 11 (COX11), chemokine C–C motif ligand 8 (CCL8), Mitogen-activated protein kinase kinase 1(MAP2K1), Amine oxidase 3 (AOC3) were significantly altered in sepsis induced cardiotoxicity. | cuproptosis-related genes |
| CP | cuproptosis | 38348451 | CP is a copper-carrying protein. Its role in cuproptosis might be linked to its functions in oxidative stress regulation. | CRGs in the cuproptosis pathway |
| CP | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| CP | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| CP | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CP | GO:0004322,GO:0005507,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005765,GO:0005788,GO:0005886,GO:0006825,GO:0006826,GO:0006879,GO:0016491,GO:0051087,GO:0070062,GO:0072562 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CP | hsa:1356 | path:hsa00860 | Porphyrin metabolism - Homo sapiens (human) |
| CP | hsa:1356 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | CP | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | CP | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | CP | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA1 | CP | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CP | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | CP | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SMARCA4 | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | CP | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IGHG1 | CP | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RAD21 | CP | 25348397 | N/A | physical interaction | ComPPI |
| PLG | CP | 14525934 146197 25348397 6582496 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| APOA1 | CP | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PROC | CP | 14525934 2105310 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| BTRC | CP | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| LTF | CP | 10666301 14525934 25348397 27898060 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| GAST | CP | 14525934 25348397 27898060 463490 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| MED20 | CP | 25348397 | N/A | physical interaction | ComPPI |
| MED4 | CP | 25348397 | N/A | physical interaction | ComPPI |
| SLC40A1 | CP | 20817278 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CP | GDPD1 | 25348397 | N/A | physical interaction | ComPPI |
| CP | DDX31 | 25348397 | N/A | physical interaction | ComPPI |
| CP | SNX27 | 25348397 | N/A | physical interaction | ComPPI |
| MPO | CP | 14525934 25348397 27898060 9097926 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| MAPT | CP | 24234451 26402096 | association | anti bait coimmunoprecipitation | IntAct |
| CP | ATP7A | 11040994 27898060 | N/A | N/A | OmniPath |
| CP | SMO | 16885213 27898060 | inhibition | N/A | OmniPath |
| SHH | CP | 14556242 15618519 17419683 27898060 9811851 | inhibition | N/A | OmniPath |
| PLG | CP | 146197 27898060 6582496 | N/A | N/A | OmniPath |
| CP | SLC40A1 | 20817278 24921009 27898060 | N/A | N/A | OmniPath |