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GENE：BNIP3L

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BNIP3L
FullNmae BCL2 interacting protein 3 like
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1085
EnsembleID ENSG00000104765
Uniprot O60238

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BNIP3L pyroptosis 36569834 In addition, administration of echinomycin rescues cognitive deficits, ameliorates HIF-1α and BNIP3L-mediated neuronal pyroptosis and damaged mitochondrial structures, and decreases the expression of TNF-α and IL-6 in the hippocampus. retulator signature
BNIP3L mpt 26517689 Upregulated BNIP3L sensitized the mitochondrial permeability transition and strongly induced PARKIN-mediated mitochondrial clearance and cellular vacuolization. retulator signature
BNIP3L autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BNIP3L autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BNIP3L autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
BNIP3L apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BNIP3L apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
BNIP3L GO:0005515,GO:0005521,GO:0005521,GO:0005634,GO:0005635,GO:0005635,GO:0005739,GO:0005741,GO:0005741,GO:0005741,GO:0005783,GO:0005783,GO:0016020,GO:0016239,GO:0016607,GO:0035694,GO:0042802,GO:0042803,GO:0043065,GO:0043066,GO:0043067,GO:0043069,GO:0051607,GO:0051607,GO:0071456,GO:0097345,GO:1903146,GO:1903214

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BNIP3L hsa:665 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BNIP3L RHEB 17928295 23180781 physical association two hybrid InnateDB
BNIP3 BNIP3L 23180781 25416956 physical association two hybrid InnateDB
BNIP3L TMEM11 23180781 25416956 physical association two hybrid InnateDB
BNIP3L CLEC7A 23180781 25416956 physical association two hybrid InnateDB
BNIP3L FATE1 23180781 25416956 physical association two hybrid InnateDB
BNIP3L LDLRAD1 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR BNIP3L 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BNIP3L 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 BNIP3L 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 BNIP3L 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A BNIP3L 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 BNIP3L 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 BNIP3L 20018759 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr miRSponge
URS0000170CF4 BNIP3L 20018759 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS0000324096 BNIP3L 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E3523 BNIP3L 24573672 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000005CF5F BNIP3L 23274497 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000366551 BNIP3L 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D BNIP3L 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 BNIP3L 25416803 26472042 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
BNIP3 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BNIP3 25361965 interaction type N/A PTMCode2
BCL2L1 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BCL2L1 25361965 interaction type N/A PTMCode2
BNIP3L STEAP3 25361965 interaction type N/A PTMCode2
STEAP3 BNIP3L 25361965 interaction type N/A PTMCode2
BAD BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BAD 25361965 interaction type N/A PTMCode2
BCL2 BNIP3L 25361965 interaction type N/A PTMCode2
BNIP3L BCL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TMEM11 BNIP3L 14525934 16189514 24234451 25348397 25416956 27107012 physical association physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid ComPPI,HPRD,IntAct
ADIPOQ BNIP3L 24234451 25348397 25910212 physical association two hybrid array,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
LMNA BNIP3L 25348397 N/A two hybrid,physical interaction ComPPI
GABARAPL2 BNIP3L 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SMCO4 BNIP3L 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MAP1LC3B BNIP3L 25348397 N/A physical interaction ComPPI
RINT1 BNIP3L 14525934 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MALL BNIP3L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FATE1 BNIP3L 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BCL2L1 BNIP3L 10467396 14525934 25348397 9973195 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BAD BNIP3L 24234451 25348397 9973195 N/A pull down ComPPI,IntAct
DUSP3 BNIP3L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EWSR1 BNIP3L 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CASK BNIP3L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NR4A1 BNIP3L 24234451 24316735 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
GNB5 BNIP3L 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GABARAP BNIP3L 25348397 N/A physical interaction ComPPI
RHEB BNIP3L 25348397 N/A physical interaction ComPPI
MAP1LC3A BNIP3L 20010802 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
BCL2 BNIP3L 10467396 14525934 24234451 25348397 9973195 N/A experimental interaction detection,pull down,physical interaction,two hybrid ComPPI,HPRD,IntAct
BNIP3 BNIP3L 10381623 16189514 19060904 21516116 24234451 25348397 25416956 27107012 physical association anti tag coimmunoprecipitation,beta galactosidase complementation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
ECM1 BNIP3L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ROBO2 BNIP3L 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STEAP3 BNIP3L 12606722 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
BNIP2 BNIP3L 10381623 24234451 25348397 physical association two hybrid ComPPI,IntAct
CAMK1D BNIP3L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GABARAPL1 BNIP3L 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOK5 BNIP3L 14525934 16189514 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GBP2 BNIP3L 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WIPI2 BNIP3L 25348397 N/A physical interaction ComPPI
CEP192 BNIP3L 25348397 N/A physical interaction ComPPI
BNIP3L KLHL23 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BNIP3L ATP13A2 22645275 24234451 25348397 physical association anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction ComPPI,IntAct
BNIP3L CLN8 25348397 N/A physical interaction ComPPI
BNIP3L CLEC7A 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BNIP3L LDLRAD1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BNIP3L PPTC7 25348397 N/A physical interaction ComPPI
BNIP3L TMPRSS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3L CYB5B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3L PRELID1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TMEM120B BNIP3L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BNIP3L BNIP3L 10381623 14525934 16189514 21516116 24234451 25416956 27107012 physical association anti tag coimmunoprecipitation,beta galactosidase complementation,two hybrid,two hybrid array,two hybrid pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid HPRD,IntAct
HTR2B BNIP3L 24234451 28298427 physical association ubiquitin reconstruction IntAct
RHEB BNIP3L 17928295 27898060 N/A N/A OmniPath
TP53 BNIP3L 18431400 27898060 stimulant N/A OmniPath
BNIP3L GABARAPL1 19363302 20010802 27898060 stimulant N/A OmniPath
SP1 BNIP3L 16291751 27898060 stimulant N/A OmniPath

Visualization










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