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GENE：NOL3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NOL3
FullNmae nucleolar protein 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7869
EnsembleID ENSG00000140939
Uniprot O60936

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NOL3 mpt 24312627 The enhanced severity of the dystrophic phenotype associated with Nol3 deletion was caspase independent but dependent on the mitochondria permeability transition pore (MPTP), as the inhibitor Debio-025 partially rescued skeletal muscle pathology in Nol3 (-/-) Sgcd (-/-) double targeted mice. retulator signature
NOL3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOL3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NOL3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NOL3 GO:0003723,GO:0005123,GO:0005509,GO:0005515,GO:0005730,GO:0005739,GO:0005739,GO:0005829,GO:0006376,GO:0006915,GO:0008380,GO:0014808,GO:0016020,GO:0016529,GO:0035877,GO:0042802,GO:0043027,GO:0043027,GO:0043066,GO:0051259,GO:0089720,GO:0089720,GO:0090201,GO:0090201,GO:1902176,GO:1903298,GO:1990001,GO:1990001,GO:2001237,GO:2001237,GO:2001243

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NOL3 NOL3 16189514 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
HIF1A NOL3 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 NOL3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NOL3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF NOL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NOL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NOL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NOL3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
AR NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
CEBPE NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ESR1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
HOXB4 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
JUN NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
LEF1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYC NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFIC NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PGR NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
POU2F2 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARD NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARG NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
RELA NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT3 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink
WT1 NOL3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 NOL3 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CSNK2A1 NOL3 22135298 phosphorylation N/A PhosphoSite
NOL3 TP53 25361965 interaction type N/A PTMCode2
TP53 NOL3 25361965 interaction type N/A PTMCode2
NOL3 FADD 25361965 interaction type N/A PTMCode2
FADD NOL3 25361965 interaction type N/A PTMCode2
NOL3 CASP2 25361965 interaction type N/A PTMCode2
CASP2 NOL3 25361965 interaction type N/A PTMCode2
NOL3 CASP8 25361965 interaction type N/A PTMCode2
CASP8 NOL3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DAXX NOL3 25348397 N/A physical interaction ComPPI
TFPT NOL3 10644725 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PACSIN3 NOL3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
VASP NOL3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDCD10 NOL3 25348397 N/A physical interaction ComPPI
PNKP NOL3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP8 NOL3 14525934 18245485 24234451 25348397 27898060 9560245 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
SIRPA NOL3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CSNK2A1 NOL3 12191471 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
FADD NOL3 14525934 15383280 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UBA6 NOL3 25348397 N/A physical interaction ComPPI
UBQLN2 NOL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP2 NOL3 14525934 25348397 9560245 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SRSF9 NOL3 10196175 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
BAX NOL3 14525934 15383280 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NUBP1 NOL3 25348397 N/A physical interaction ComPPI
STK39 NOL3 25348397 N/A physical interaction ComPPI
NOL3 NIF3L1 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
NOL3 ETNK2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
NOL3 TERF1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
NOL3 TERF2IP 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
NOL3 TINF2 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
NOL3 POT1 21044950 24234451 25348397 physical association physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
NOL3 EHD4 25348397 N/A physical interaction ComPPI
NOL3 AASDHPPT 25348397 N/A physical interaction ComPPI
NOL3 EHD1 25348397 N/A physical interaction ComPPI
NOL3 FKBP9 25348397 N/A physical interaction ComPPI
NOL3 GNPDA2 25348397 N/A physical interaction ComPPI
NOL3 GTF3C4 25348397 N/A physical interaction ComPPI
NOL3 H2AZ1 25348397 N/A physical interaction ComPPI
NOL3 IPO9 25348397 N/A physical interaction ComPPI
NOL3 NAPRT 25348397 N/A physical interaction ComPPI
NOL3 PSMG1 25348397 N/A physical interaction ComPPI
NOL3 XPNPEP1 25348397 N/A physical interaction ComPPI
NOL3 TP53 18087040 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
NOL3 NOL3 14525934 16189514 24234451 physical association pull down,two hybrid pooling approach,two hybrid HPRD,IntAct
NOL3 FADD 15383280 27898060 inhibition N/A OmniPath
NOL3 FAS 15383280 27898060 inhibition N/A OmniPath
CSNK2A1 NOL3 12191471 26172393 27898060 N/A N/A OmniPath
NOL3 BAX 15383280 27898060 stimulant N/A OmniPath

Visualization










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