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GENE：SLC9A1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC9A1
FullNmae solute carrier family 9 member A1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11071
EnsembleID ENSG00000090020
Uniprot P19634

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC9A1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SLC9A1 GO:0005515,GO:0005516,GO:0005543,GO:0005546,GO:0005654,GO:0005737,GO:0005739,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006811,GO:0006883,GO:0006885,GO:0006885,GO:0009986,GO:0010447,GO:0010613,GO:0010882,GO:0014704,GO:0015385,GO:0015385,GO:0015385,GO:0015385,GO:0015386,GO:0016020,GO:0016323,GO:0016324,GO:0016477,GO:0030011,GO:0030027,GO:0030307,GO:0030315,GO:0030346,GO:0030346,GO:0030674,GO:0032869,GO:0035794,GO:0035994,GO:0036376,GO:0042802,GO:0043065,GO:0043066,GO:0043167,GO:0045121,GO:0045760,GO:0045944,GO:0048306,GO:0048471,GO:0048863,GO:0051259,GO:0051453,GO:0051453,GO:0051492,GO:0051893,GO:0055007,GO:0060090,GO:0070062,GO:0070417,GO:0070886,GO:0071236,GO:0071257,GO:0071260,GO:0071456,GO:0071468,GO:0071468,GO:0071805,GO:0071872,GO:0086003,GO:0086036,GO:0086040,GO:0086092,GO:0090533,GO:0098719,GO:0098719,GO:0098735,GO:1902600,GO:1903281

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC9A1 hsa:6548 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04970 Salivary secretion - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04972 Pancreatic secretion - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa04976 Bile secretion - Homo sapiens (human)
SLC9A1 hsa:6548 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CA2 SLC9A1 12138085 16475831 23180781 physical association anti tag coimmunoprecipitation InnateDB
CHP1 SLC9A1 11350981 11696366 23180781 8901634 physical association two hybrid,far western blotting,pull down InnateDB
CHP2 SLC9A1 16710297 23180781 physical association x-ray crystallography InnateDB
TESC SLC9A1 11696366 23180781 physical association two hybrid,pull down InnateDB
NEDD4 SLC9A1 20855896 23180781 physical association anti tag coimmunoprecipitation InnateDB
ARRB1 SLC9A1 20855896 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
SLC9A1 MAP4K4 20005715 interaction type N/A PSP
SLC9A1 MAPK1 20005715 interaction type N/A PSP
SLC9A1 MAPK14 20005715 interaction type N/A PSP
SLC9A1 MAP4K4 20005715 20005715 20936779 21071413 N/A N/A SignaLink
SLC9A1 MAPK1 20005715 20005715 N/A N/A SignaLink
SLC9A1 MAPK14 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR SLC9A1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SLC9A1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SLC9A1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC9A1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SLC9A1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARA SLC9A1 19958503 trascriptional regulation,stimulation inferred by curator TFlink
PPARG SLC9A1 19887620 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 SLC9A1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC SLC9A1 17612493 23592263 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00001597DC SLC9A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 SLC9A1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B968D SLC9A1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SLC9A1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 SLC9A1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F SLC9A1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 SLC9A1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 SLC9A1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002367FA SLC9A1 25416803 26521941 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK14 SLC9A1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 SLC9A1 22135298 phosphorylation N/A PhosphoSite
ROCK1 SLC9A1 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 SLC9A1 22135298 phosphorylation N/A PhosphoSite
ROCK2 SLC9A1 22135298 phosphorylation N/A PhosphoSite
BRAF SLC9A1 22135298 phosphorylation N/A PhosphoSite
AKT1 SLC9A1 22135298 phosphorylation N/A PhosphoSite
SLC9A1 MAPK14 25361965 interaction type N/A PTMCode2
SLC9A1 CA2 25361965 interaction type N/A PTMCode2
CA2 SLC9A1 25361965 interaction type N/A PTMCode2
SLC9A1 CHP2 25361965 interaction type N/A PTMCode2
CHP2 SLC9A1 25361965 interaction type N/A PTMCode2
SLC9A1 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB SLC9A1 25361965 interaction type N/A PTMCode2
SLC9A1 MAP4K4 25361965 interaction type N/A PTMCode2
MAP4K4 SLC9A1 25361965 interaction type N/A PTMCode2
SLC9A1 TESC 25361965 interaction type N/A PTMCode2
TESC SLC9A1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I SLC9A1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DAXX SLC9A1 25348397 N/A physical interaction ComPPI
CALM1 SLC9A1 25348397 N/A physical interaction ComPPI
ROCK1 SLC9A1 25348397 N/A physical interaction ComPPI
MDFI SLC9A1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MAPK1 SLC9A1 14525934 15253667 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
AOC3 SLC9A1 25348397 N/A physical interaction ComPPI
MAPK14 SLC9A1 11604491 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CA2 SLC9A1 12138085 14525934 16475831 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SLC9A1 YWHAB 11279064 14525934 16717153 24234451 25348397 27898060 association coimmunoprecipitation,experimental interaction detection,filter binding,pull down,in vitro ComPPI,HPRD,IntAct,OmniPath
SLC9A1 MAP4K4 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,IntAct
SLC9A1 CHP1 11350981 11696366 12576672 14525934 25348397 27898060 8901634 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SLC9A1 TESC 11696366 12809501 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
SLC9A1 CHP2 14525934 16710297 24234451 25348397 N/A biophysical,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SLC9A1 WNK1 25348397 N/A physical interaction ComPPI
SLC9A1 NEDD4 25348397 N/A physical interaction ComPPI
SLC9A1 ARRB1 25348397 N/A physical interaction ComPPI
SLC9A1 RPS6KA6 25348397 N/A physical interaction ComPPI
SLC9A1 LYPD3 25348397 N/A physical interaction ComPPI
SLC9A1 FAM189A2 25348397 N/A physical interaction ComPPI
SLC9A1 PTGER3 25348397 N/A physical interaction ComPPI
SLC9A1 LPAR1 25348397 N/A physical interaction ComPPI
SLC9A1 TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SLC9A1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SLC9A1 AP4S1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SLC9A1 CDH1 25348397 N/A physical interaction ComPPI
SLC9A1 IPPK 25348397 N/A physical interaction ComPPI
SLC9A1 GALNT7 25348397 N/A physical interaction ComPPI
SLC9A1 FNDC5 25348397 N/A physical interaction ComPPI
SLC9A1 SLCO6A1 25348397 N/A physical interaction ComPPI
SLC9A1 CCDC107 25348397 N/A physical interaction ComPPI
SLC9A1 PTGIR 25348397 N/A physical interaction ComPPI
SLC9A1 SEMA7A 25348397 N/A physical interaction ComPPI
SLC9A1 FUT1 25348397 N/A physical interaction ComPPI
SLC9A1 SLC20A1 25348397 N/A physical interaction ComPPI
SLC9A1 TCTN2 25348397 N/A physical interaction ComPPI
SLC9A1 GALNT6 25348397 N/A physical interaction ComPPI
SLC9A1 AKT1 25348397 N/A physical interaction ComPPI
SLC9A1 HSPA4 25348397 N/A physical interaction ComPPI
SLC9A1 HSP90AA1 25348397 N/A physical interaction ComPPI
SLC9A1 HSP90AA2P 25348397 N/A physical interaction ComPPI
SLC9A1 ENO1 25348397 N/A physical interaction ComPPI
SLC9A1 YWHAZ 11279064 24234451 25348397 association pull down ComPPI,IntAct
SLC9A1 MAP3K7 20936779 24234451 25348397 N/A pull down ComPPI,IntAct
MAP3K14 SLC9A1 25348397 N/A physical interaction ComPPI
ARRB1 SLC9A1 20855896 27898060 N/A N/A OmniPath
RPS6KA1 SLC9A1 10400637 27898060 stimulant N/A OmniPath
AKT1 SLC9A1 10400637 16475831 18757828 20026127 25162926 27898060 stimulant N/A OmniPath
MAPK14 SLC9A1 10400637 11604491 18669648 18701649 20068231 23602949 27898060 stimulant N/A OmniPath
ROCK2 SLC9A1 25578862 27898060 stimulant N/A OmniPath
MAPK1 SLC9A1 15253667 17209041 18088087 18669648 19415658 20058876 20068231 23678047 27898060 stimulant N/A OmniPath

Visualization










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