GENE：ALOX12
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ALOX12 |
| FullNmae | arachidonate 12-lipoxygenase, 12S type |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:429 |
| EnsembleID | ENSG00000108839 |
| Uniprot | P18054 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ALOX12 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ALOX12 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ALOX12 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ALOX12 | GO:0004052,GO:0004052,GO:0005506,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006629,GO:0010656,GO:0016020,GO:0016165,GO:0016165,GO:0019369,GO:0019369,GO:0019369,GO:0019372,GO:0019372,GO:0019395,GO:0019395,GO:0033559,GO:0034440,GO:0042383,GO:0042383,GO:0042554,GO:0043651,GO:0043651,GO:0047977,GO:0050473,GO:0050473,GO:0051122,GO:0051122,GO:0061436,GO:0070062,GO:0090331,GO:1901751,GO:2001303,GO:2001306 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ALOX12 | hsa:239 | path:hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| ALOX12 | hsa:239 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| ALOX12 | hsa:239 | path:hsa01523 | Antifolate resistance - Homo sapiens (human) |
| ALOX12 | hsa:239 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| ALOX12 | hsa:239 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ALOX12 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | ALOX12 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | ALOX12 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | ALOX12 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ALOX12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ALOX12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ALOX12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ALOX12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ALOX12 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | ALOX12 | 14518567 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ALOX12 | 20181616 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | ALOX12 | 14518567 16118214 9164849 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | ALOX12 | 14518567 16118214 9164849 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | ALOX12 | 9164849 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT6 | ALOX12 | 10657944 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000040EE1D | ALOX12 | 22815788 25416803 | mrna cleavage,inhibition | array technology,quantitative reverse transcription pcr | TarBase |
| URS00002367FA | ALOX12 | 24070899 25416803 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRT5 | ALOX12 | 10727209 14525934 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,confocal microscopy | ComPPI,HPRD,IntAct |
| LMNA | ALOX12 | 10727209 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,physical interaction | ComPPI,IntAct |
| PLA2G2A | ALOX12 | 14525934 15474031 24234451 25348397 | physical association | coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| TRIB1 | ALOX12 | 10727209 14525934 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| ITGB4 | ALOX12 | 10727209 14525934 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| PLA2G4A | ALOX12 | 25348397 | N/A | physical interaction | ComPPI |
| ALOX12 | KAT5 | 14525934 15474031 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ALOX12 | KRT85 | 10727209 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| ALOX12 | ACTA2 | 25348397 | N/A | physical interaction | ComPPI |