GENE：GDNF
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GDNF |
| FullNmae | glial cell derived neurotrophic factor |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4232 |
| EnsembleID | ENSG00000168621 |
| Uniprot | P39905 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GDNF | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GDNF | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GDNF | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GDNF | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GDNF | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| GDNF | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GDNF | GO:0001656,GO:0001658,GO:0001755,GO:0001759,GO:0001941,GO:0003337,GO:0005102,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005794,GO:0007165,GO:0007399,GO:0007422,GO:0008083,GO:0008284,GO:0008344,GO:0010468,GO:0021516,GO:0021784,GO:0030116,GO:0030432,GO:0030971,GO:0031175,GO:0031175,GO:0032770,GO:0033603,GO:0042803,GO:0043066,GO:0043524,GO:0043524,GO:0045597,GO:0045944,GO:0048255,GO:0048484,GO:0048485,GO:0048568,GO:0051584,GO:0060676,GO:0060688,GO:0061642,GO:0071679,GO:0072107,GO:0072108,GO:0090190,GO:0090190,GO:1902379,GO:2000736,GO:2001240,GO:2001260 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GDNF | hsa:2668 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| GDNF | hsa:2668 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| GDNF | hsa:2668 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA2 | GDNF | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | GDNF | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| CEBPA | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GDNF | 18971253 9729303 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | GDNF | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | GDNF | 9729303 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | GDNF | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | GDNF | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000521626 | GDNF | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000821E0 | GDNF | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005E6F45 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FF522 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002ECEE4 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000043D2C1 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BC299 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | GDNF | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000096022 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BA274 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041E949 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000346991 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CBE63 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000081E1F | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000195F5B | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CCBB9 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004A9320 | GDNF | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F5FEE | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002233F4 | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F7766 | GDNF | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FF9C | GDNF | 25416803 26681446 | mrna cleavage,inhibition | experimental interaction detection,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| COPS5 | GDNF | 25348397 | N/A | physical interaction | ComPPI |
| PTPRA | GDNF | 24234451 25348397 28330616 | association | pull down | ComPPI,IntAct |
| AGTRAP | GDNF | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| RANBP9 | GDNF | 25348397 | N/A | physical interaction | ComPPI |
| RMND5A | GDNF | 25348397 | N/A | physical interaction | ComPPI |
| RET | GDNF | 14525934 25348397 8674117 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RANBP10 | GDNF | 25348397 | N/A | physical interaction | ComPPI |
| GFRA1 | GDNF | 14525934 25348397 8674117 9482105 | N/A | experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo | ComPPI,HPRD |
| GDNF | GFRA2 | 14525934 25348397 9407096 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| GDNF | NCAM1 | 12837245 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| GDNF | MAEA | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | MKLN1 | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | ARMC8 | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | S100A10 | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | GID4 | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | YPEL5 | 25348397 | N/A | physical interaction | ComPPI |
| GDNF | NDUFS6 | 24234451 25348397 25416956 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| GDNF | GDNF | 11842239 14525934 | N/A | experimental interaction detection | HPRD |
| PRKACA | GDNF | 1655749 27898060 | stimulant | N/A | OmniPath |
| GDNF | RET | 27898060 8674117 9182803 | stimulant | N/A | OmniPath |
| CREB1 | GDNF | 1655749 27898060 | stimulant | N/A | OmniPath |
| GDNF | GFRA1 | 10829012 11106404 14514671 20473317 27898060 8674117 9182803 9192898 9407096 9482105 | stimulant | N/A | OmniPath |
| GDNF | GFRA2 | 10829012 27898060 9192898 9407096 | stimulant | N/A | OmniPath |