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GENE：ECHS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ECHS1
FullNmae enoyl-CoA hydratase, short chain 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3151
EnsembleID ENSG00000127884
Uniprot P30084

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ECHS1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ECHS1 GO:0004165,GO:0004300,GO:0004300,GO:0004300,GO:0004300,GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005759,GO:0006635,GO:0006635,GO:0006635,GO:0006635,GO:0009083,GO:0043956,GO:0120092

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ECHS1 hsa:1892 path:hsa00062 Fatty acid elongation - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00310 Lysine degradation - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00380 Tryptophan metabolism - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00410 beta-Alanine metabolism - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00640 Propanoate metabolism - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa00650 Butanoate metabolism - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa01200 Carbon metabolism - Homo sapiens (human)
ECHS1 hsa:1892 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TLR1 ECHS1 16482509 23180781 physical association two hybrid InnateDB
TLR10 ECHS1 16482509 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ECHS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA ECHS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ECHS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ECHS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ECHS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ECHS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 ECHS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000C73C ECHS1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000041CB9C ECHS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
ECHS1 ECHS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EIF1B ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TPD52L2 ECHS1 25348397 N/A physical interaction ComPPI
PPIB ECHS1 25348397 N/A physical interaction ComPPI
PAK2 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATPAF2 ECHS1 25348397 N/A physical interaction ComPPI
PCBP1 ECHS1 25348397 N/A physical interaction ComPPI
FASTKD3 ECHS1 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TRAF6 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GABARAPL2 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SMURF2 ECHS1 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
SND1 ECHS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GRB2 ECHS1 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SLC9A3R1 ECHS1 25348397 N/A physical interaction ComPPI
CTBP1 ECHS1 25348397 N/A physical interaction ComPPI
TGM2 ECHS1 25348397 N/A physical interaction ComPPI
RAP1GDS1 ECHS1 25348397 N/A physical interaction ComPPI
YWHAZ ECHS1 15161933 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
DLD ECHS1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBE2N ECHS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NTRK1 ECHS1 25348397 N/A physical interaction ComPPI
HERC1 ECHS1 25348397 N/A physical interaction ComPPI
BAG6 ECHS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SERPINA1 ECHS1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
VCL ECHS1 25348397 N/A physical interaction ComPPI
PA2G4 ECHS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CAMK2G ECHS1 25348397 N/A physical interaction ComPPI
RAP1A ECHS1 25348397 N/A physical interaction ComPPI
TNIK ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAQ ECHS1 25348397 N/A physical interaction ComPPI
TRAP1 ECHS1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CAMK2D ECHS1 25348397 N/A physical interaction ComPPI
SUMO3 ECHS1 25348397 N/A physical interaction ComPPI
SYNCRIP ECHS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VHL ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TIMP2 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIM63 ECHS1 18157088 24234451 25348397 physical association two hybrid ComPPI,IntAct
HSPA9 ECHS1 25348397 N/A physical interaction ComPPI
RIPK2 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CUL7 ECHS1 25348397 N/A physical interaction ComPPI
PPM1B ECHS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDK1 ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TFE3 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UBA1 ECHS1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TRIM25 ECHS1 25348397 N/A physical interaction ComPPI
YEATS4 ECHS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAT3 ECHS1 23416296 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
TALDO1 ECHS1 25348397 N/A physical interaction ComPPI
CAPN1 ECHS1 12358155 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
UBE2V1 ECHS1 25348397 N/A physical interaction ComPPI
AURKAIP1 ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKAB1 ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IKBKE ECHS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RAB11FIP5 ECHS1 25348397 N/A physical interaction ComPPI
CNDP2 ECHS1 25348397 N/A physical interaction ComPPI
UCHL5 ECHS1 25348397 N/A physical interaction ComPPI
HSPD1 ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SAV1 ECHS1 22570112 24234451 25348397 physical association two hybrid ComPPI,IntAct
ECHS1 CBWD2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ECHS1 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ECHS1 UBA5 25348397 N/A physical interaction ComPPI
ECHS1 CYP2E1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ECHS1 CLDN12 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ECHS1 ABHD14A 25348397 N/A physical interaction ComPPI
ECHS1 GSS 25348397 N/A physical interaction ComPPI
ECHS1 PFAS 25348397 N/A physical interaction ComPPI
ECHS1 USP14 25348397 N/A physical interaction ComPPI
ECHS1 GINS3 25348397 N/A physical interaction ComPPI
ECHS1 PPP4R3B 25348397 N/A physical interaction ComPPI
ECHS1 MOV10 25348397 N/A physical interaction ComPPI
ECHS1 NXF1 25348397 N/A physical interaction ComPPI
ECHS1 DBT 25348397 N/A physical interaction ComPPI
ECHS1 USP15 25348397 N/A physical interaction ComPPI
ECHS1 ADI1 25348397 N/A physical interaction ComPPI
ECHS1 AHCYL1 25348397 N/A physical interaction ComPPI
ECHS1 AKR1A1 25348397 N/A physical interaction ComPPI
ECHS1 ALDOA 25348397 N/A physical interaction ComPPI
ECHS1 ABCC1 25348397 N/A physical interaction ComPPI
ECHS1 ISYNA1 25348397 N/A physical interaction ComPPI
ECHS1 ITPA 25348397 N/A physical interaction ComPPI
ECHS1 NEDD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ECHS1 YPEL5 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
ECHS1 ATG5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECHS1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECHS1 FTSJ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECHS1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECHS1 GH1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ECHS1 LRRK2 24234451 24510904 24947832 25348397 N/A protein array ComPPI,IntAct
ECHS1 LRRK1 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
ECHS1 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
ECHS1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
ECHS1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
COX4I1 ECHS1 25348397 N/A physical interaction ComPPI
MGST3 ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DDA1 ECHS1 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRMT61B ECHS1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DCPS ECHS1 25348397 N/A physical interaction ComPPI
ECHS1 ECHS1 21988832 24234451 physical association two hybrid IntAct
ECHS1 ZNF157 24234451 30021884 physical association cross-linking study IntAct
TLR1 ECHS1 16482509 27898060 N/A N/A OmniPath

Visualization










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