GENE：PCCA
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PCCA |
| FullNmae | propionyl-CoA carboxylase subunit alpha |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8653 |
| EnsembleID | ENSG00000175198 |
| Uniprot | P05165 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PCCA | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PCCA | GO:0004658,GO:0004658,GO:0004658,GO:0005515,GO:0005524,GO:0005739,GO:0005739,GO:0005759,GO:0005759,GO:0005759,GO:0005829,GO:0006631,GO:0009081,GO:0009374,GO:0019626,GO:0019899,GO:0046872,GO:1902494 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PCCA | hsa:5095 | path:hsa00280 | Valine, leucine and isoleucine degradation - Homo sapiens (human) |
| PCCA | hsa:5095 | path:hsa00630 | Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) |
| PCCA | hsa:5095 | path:hsa00640 | Propanoate metabolism - Homo sapiens (human) |
| PCCA | hsa:5095 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PCCA | hsa:5095 | path:hsa01200 | Carbon metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PCCA | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | PCCA | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PCCA | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | PCCA | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | PCCA | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PCCA | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | PCCA | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000003ABC4 | PCCA | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000AD002 | PCCA | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000338542 | PCCA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000555DA6 | PCCA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041CB9C | PCCA | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LGALS3 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| KEAP1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| ERRFI1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| ICMT | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| UBE2N | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| PARP2 | PCCA | 21812934 24234451 25348397 | adp ribosylation reaction | protein array | ComPPI,IntAct |
| HNRNPL | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| HUWE1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| TTC1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| PTEN | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| PRKN | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| PJA1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| NFKB1 | PCCA | 24234451 25348397 25609649 | association | tandem affinity purification | ComPPI,IntAct |
| SGK1 | PCCA | 25348397 | N/A | physical interaction | ComPPI |
| BAG2 | PCCA | 18457437 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| PCCA | IFIT1 | 21642987 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PCCA | ZNF746 | 25348397 | N/A | physical interaction | ComPPI |
| PCCA | NTAQ1 | 25348397 | N/A | physical interaction | ComPPI |
| PCCA | PPP2R2B | 19156129 24234451 25348397 | association | pull down | ComPPI,IntAct |
| PCCA | SIRT4 | 24234451 25348397 25525879 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| PCCA | MCC | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |