GENE：HFE
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | HFE |
| FullNmae | homeostatic iron regulator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4886 |
| EnsembleID | ENSG00000010704 |
| Uniprot | Q30201 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| HFE | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HFE | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| HFE | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| HFE | GO:0001916,GO:0002476,GO:0002486,GO:0002725,GO:0005102,GO:0005515,GO:0005615,GO:0005615,GO:0005654,GO:0005769,GO:0005886,GO:0005886,GO:0006879,GO:0006953,GO:0007565,GO:0009897,GO:0009897,GO:0010039,GO:0010106,GO:0010628,GO:0030509,GO:0030881,GO:0031410,GO:0032092,GO:0032435,GO:0034755,GO:0034756,GO:0034756,GO:0039706,GO:0042446,GO:0045177,GO:0045178,GO:0048260,GO:0048471,GO:0055037,GO:0060586,GO:0065003,GO:0071281,GO:0090277,GO:0097421,GO:1900121,GO:1900122,GO:1904283,GO:1904434,GO:1904437,GO:1990357,GO:1990459,GO:1990459,GO:1990641,GO:1990712,GO:2000008,GO:2000059,GO:2000272,GO:2000273,GO:2001186 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| HFE | hsa:3077 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TFR2 | HFE | 19254567 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| HFE | TFRC | 19254567 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| TF | HFE | 19254567 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | HFE | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | HFE | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | HFE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | HFE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | HFE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | HFE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | HFE | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PARP1 | HFE | 24184271 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF2 | HFE | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | HFE | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETV4 | HFE | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | HFE | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TFAP2A | HFE | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000012A1DD | HFE | 23708087 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| URS000008DA94 | HFE | 23708087 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| URS0000171525 | HFE | 23708087 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| URS00000451A1 | HFE | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000015F70F | HFE | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A281 | HFE | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B0E50 | HFE | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TFRC | HFE | 14525934 15965644 20618438 24234451 25348397 9465039 | colocalization,physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| UBB | HFE | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBC | HFE | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| RPS27A | HFE | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| UBA52 | HFE | 25348397 | N/A | anti tag coimmunoprecipitation,physical interaction | ComPPI |
| HSPA5 | HFE | 20618438 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| SYVN1 | HFE | 25348397 | N/A | physical interaction | ComPPI |
| TFR2 | HFE | 10638746 14525934 25348397 9465039 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| HFE | B2M | 10791995 14525934 15965644 20618438 24234451 25348397 27898060 9546397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct,OmniPath |
| HFE | TF | 20618438 24234451 25348397 | colocalization | fluorescence microscopy | ComPPI,IntAct |
| HFE | TFR2 | 10638746 16893896 19254567 27898060 9465039 | N/A | N/A | OmniPath |
| TFR2 | HFE | 10638746 16893896 19254567 27898060 9465039 | N/A | N/A | OmniPath |