GENE：NEO1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NEO1 |
| FullNmae | neogenin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7754 |
| EnsembleID | ENSG00000067141 |
| Uniprot | Q92859 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NEO1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NEO1 | GO:0001764,GO:0005515,GO:0005654,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006355,GO:0006879,GO:0007155,GO:0007411,GO:0007520,GO:0009306,GO:0009986,GO:0030513,GO:0038023,GO:0039706,GO:0044295,GO:0045296,GO:0048681,GO:0050709,GO:0060586,GO:0070700,GO:0097708,GO:0098609,GO:0098797 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NEO1 | hsa:4756 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| NEO1 | hsa:4756 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| NEO1 | hsa:4756 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA3 | NEO1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | NEO1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | NEO1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272039 | NEO1 | 20371350 23313552 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00002FC5B0 | NEO1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00005651EE | NEO1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003CF1AD | NEO1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000345DEB | NEO1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | NEO1 | 24657544 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr | TarBase |
| URS000015188E | NEO1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CE0C6 | NEO1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NEO1 | NTN3 | 25361965 | interaction type | N/A | PTMCode2 |
| NTN3 | NEO1 | 25361965 | interaction type | N/A | PTMCode2 |
| NEO1 | UNC5B | 25361965 | interaction type | N/A | PTMCode2 |
| UNC5B | NEO1 | 25361965 | interaction type | N/A | PTMCode2 |
| NTN1 | NEO1 | 25361965 | interaction type | N/A | PTMCode2 |
| NEO1 | NTN1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TTN | NEO1 | 23414517 24234451 25348397 | physical association | two hybrid fragment pooling approach | ComPPI,IntAct |
| TNF | NEO1 | 25348397 | N/A | physical interaction | ComPPI |
| BMP2 | NEO1 | 18335997 24234451 25348397 | physical association | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| ELAVL1 | NEO1 | 25348397 | N/A | physical interaction | ComPPI |
| NTN1 | NEO1 | 12636918 14525934 18719102 24234451 25348397 27898060 8861902 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct,OmniPath |
| UNC5B | NEO1 | 18719102 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NTN4 | NEO1 | 18719102 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PTK2 | NEO1 | 25348397 | N/A | physical interaction | ComPPI |
| NEO1 | HJV | 18335997 24234451 25348397 | N/A | pull down,static light scattering,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| NEO1 | NTN3 | 10366627 14525934 | N/A | experimental interaction detection | HPRD |
| PITPNA | NEO1 | 14525934 16244667 | N/A | experimental interaction detection,two hybrid | HPRD |
| NEO1 | DAPK1 | 18583991 27898060 | stimulant | N/A | OmniPath |
| NEO1 | CDON | 15520228 27898060 | N/A | N/A | OmniPath |
| RGMA | NEO1 | 15258590 27898060 | stimulant | N/A | OmniPath |
| RGMB | NEO1 | 19944164 27898060 | N/A | N/A | OmniPath |