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GENE：TGM2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TGM2
FullNmae transglutaminase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11778
EnsembleID ENSG00000198959
Uniprot P21980

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TGM2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TGM2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TGM2 GO:0000785,GO:0000786,GO:0003810,GO:0003810,GO:0003810,GO:0003810,GO:0005509,GO:0005515,GO:0005525,GO:0005634,GO:0005739,GO:0005739,GO:0005783,GO:0005829,GO:0005886,GO:0005886,GO:0005925,GO:0006338,GO:0006508,GO:0007200,GO:0008233,GO:0010467,GO:0014046,GO:0018149,GO:0018149,GO:0018277,GO:0031012,GO:0032471,GO:0042981,GO:0043065,GO:0043277,GO:0043547,GO:0045785,GO:0048471,GO:0050568,GO:0050769,GO:0051057,GO:0051561,GO:0060348,GO:0060445,GO:0060662,GO:0062023,GO:0070062,GO:0071314,GO:0120295,GO:0120297,GO:0120298,GO:0120299,GO:1903351,GO:1904015,GO:2000425

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TGM2 hsa:7052 path:hsa05016 Huntington disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ANXA1 TGM2 20005715 interaction type N/A PSP
HTT TGM2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR TGM2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TGM2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ESR2 TGM2 20034404 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 TGM2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TGM2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 TGM2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TGM2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 TGM2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 TGM2 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 TGM2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000EED18 TGM2 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 TGM2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000007340 TGM2 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA TGM2 22135298 phosphorylation N/A PhosphoSite
TGM2 H3C1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
KRT19 TGM2 20080707 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KPNA3 TGM2 10100610 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
KPNA4 TGM2 10100610 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
HSPA8 TGM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK2 TGM2 25348397 N/A physical interaction ComPPI
LDHB TGM2 25348397 N/A physical interaction ComPPI
ATF4 TGM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBB TGM2 25348397 N/A in vitro,in vivo ComPPI
GSTP1 TGM2 14525934 25348397 9973324 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACTB TGM2 14525934 25348397 27898060 9252372 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
YWHAG TGM2 25348397 N/A physical interaction ComPPI
CALM1 TGM2 25348397 N/A physical interaction ComPPI
H2BC4 TGM2 14525934 25348397 9973324 N/A experimental interaction detection,in vivo ComPPI,HPRD
ZNF512B TGM2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MCM2 TGM2 25348397 N/A physical interaction ComPPI
SF3B4 TGM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PLOD3 TGM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SERTAD1 TGM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK1 TGM2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBL TGM2 25348397 N/A physical interaction ComPPI
SRC TGM2 20080707 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP3 TGM2 10556977 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RB1 TGM2 14525934 25348397 9315663 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMAD2 TGM2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 TGM2 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SLC9A3R1 TGM2 25348397 N/A physical interaction ComPPI
ITGB1 TGM2 25348397 N/A in vivo ComPPI
RHOA TGM2 11350930 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TGM2 ITGB3 10684262 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TGM2 SPARC 14525934 25348397 27898060 7730416 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TGM2 SERPINF2 10958788 10963790 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGM2 EIF5A 14525934 25348397 27898060 9442029 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
TGM2 S100A7 11258932 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TGM2 MAP3K12 25348397 N/A in vitro ComPPI
TGM2 H2BC21 14525934 25348397 9973324 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TGM2 PLCD1 10518533 14525934 24234451 25348397 9512491 N/A experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
TGM2 PPHLN1 12853457 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TGM2 RELA 14525934 16951195 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,confocal microscopy ComPPI,HPRD,IntAct
TGM2 ALDOA 1353685 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TGM2 HTT 11442349 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
TGM2 LTBP1 14525934 25348397 27898060 9060478 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TGM2 FN1 11686302 11829448 14525934 19738201 20080707 22442151 24234451 25348397 27898060 enzymatic reaction,association cross-linking study,experimental interaction detection,pull down,physical interaction,enzyme linked immunosorbent assay,enzymatic study ComPPI,HPRD,IntAct,OmniPath
TGM2 THBS1 19542224 24234451 25348397 N/A surface plasmon resonance array ComPPI,IntAct
TGM2 PSMD4 19931242 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct,OmniPath
TGM2 PCOLCE 24117177 24234451 25348397 N/A surface plasmon resonance array ComPPI,IntAct
TGM2 H3-4 25348397 N/A physical interaction ComPPI
TGM2 PIAS4 25348397 N/A physical interaction ComPPI
TGM2 SQSTM1 25348397 N/A physical interaction ComPPI
TGM2 APP 25348397 N/A physical interaction ComPPI
TGM2 VHL 21625219 24234451 25348397 27898060 transglutamination reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,enzymatic study ComPPI,IntAct,OmniPath
TGM2 CDH1 16212417 24234451 25348397 physical association surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
TGM2 ADAR 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 HSPA1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 HSPA1B 25348397 N/A two hybrid,physical interaction ComPPI
TGM2 TMEM176A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 A2M 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 ABCA1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 BNIP3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 C3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 FNTA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 GCGR 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 GRN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 HP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 CERT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 HNRNPUL1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 SLC7A9 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 TAB2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TGM2 ANKRD28 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 SIPA1L2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TGM2 FBXO6 25348397 N/A physical interaction ComPPI
TGM2 G6PD 25348397 N/A physical interaction ComPPI
TGM2 PGD 25348397 N/A physical interaction ComPPI
TGM2 RPS6KA3 25348397 N/A physical interaction ComPPI
TGM2 CNDP2 25348397 N/A physical interaction ComPPI
TGM2 CSE1L 25348397 N/A physical interaction ComPPI
TGM2 ECHS1 25348397 N/A physical interaction ComPPI
TGM2 NPEPPS 25348397 N/A physical interaction ComPPI
TGM2 PPP4R3B 25348397 N/A physical interaction ComPPI
TGM2 UBE2V1 25348397 N/A physical interaction ComPPI
TGM2 TXNDC5 25348397 N/A physical interaction ComPPI
TGM2 UBFD1 25348397 N/A physical interaction ComPPI
TGM2 YWHAZ 25348397 N/A physical interaction ComPPI
TGM2 ZFYVE19 25348397 N/A physical interaction ComPPI
TGM2 PINK1 25348397 25557247 27898060 N/A physical interaction ComPPI,OmniPath
TGM2 CDK11B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 CDK11A 25348397 N/A physical interaction ComPPI
TGM2 COL5A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 COL5A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 CDC42BPA 25348397 N/A physical interaction ComPPI
TGM2 SRGAP3 25348397 N/A physical interaction ComPPI
TGM2 ENOPH1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 RBM25 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 COLGALT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 TMEM126A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 POLR1F 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TGM2 LACRT 25348397 N/A physical interaction ComPPI
TGM2 TP53 25348397 N/A physical interaction ComPPI
TGM2 PLA2G2A 25348397 N/A physical interaction ComPPI
TGM2 YAP1 25348397 N/A physical interaction ComPPI
TGM2 CFTR 25348397 N/A physical interaction ComPPI
TGM2 ARNT 25348397 N/A physical interaction ComPPI
TGM2 AKAP13 16301118 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,two hybrid,confocal microscopy ComPPI,IntAct,OmniPath
TGM2 UBC 19183553 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
TGM2 NME1 19619546 24234451 25348397 27898060 association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
MVP TGM2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NFKBIA TGM2 16951195 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAQ TGM2 25348397 N/A physical interaction ComPPI
CSNK2A2 TGM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPF TGM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CKB TGM2 25348397 N/A physical interaction ComPPI
TGM2 TGM2 10100610 11867708 14525934 21988832 24234451 physical association two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
TUBB2A TGM2 14525934 9973324 N/A experimental interaction detection HPRD
TMSB4X TGM2 10611475 14525934 27898060 N/A experimental interaction detection HPRD,OmniPath
TGM2 ANXA1 14525934 1670773 27898060 N/A experimental interaction detection HPRD,OmniPath
PRKACA TGM2 16870138 22142843 27898060 N/A N/A OmniPath
TGM2 TRPV5 21952826 27898060 inhibition N/A OmniPath
TGM2 H3C1 16407273 27898060 stimulant N/A OmniPath
TGM2 SDC4 23499501 27898060 N/A N/A OmniPath
TGM2 ADGRG1 16757564 27898060 stimulant N/A OmniPath

Visualization










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