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GENE：THEM4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol THEM4
FullNmae thioesterase superfamily member 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17947
EnsembleID ENSG00000159445
Uniprot Q5T1C6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
THEM4 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
THEM4 GO:0005515,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0005829,GO:0005829,GO:0005886,GO:0006631,GO:0016290,GO:0032587,GO:0043491,GO:0102991,GO:1902108

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
THEM4 hsa:117145 path:hsa00062 Fatty acid elongation - Homo sapiens (human)
THEM4 hsa:117145 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AKT1 THEM4 11598301 23180781 physical association anti tag coimmunoprecipitation InnateDB
THEM4 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 THEM4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 THEM4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 THEM4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000065D58 THEM4 18668040 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,experimental interaction detection TarBase
URS00001067D1 THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070B1D THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA THEM4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000482389 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B THEM4 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AKT1 THEM4 25361965 interaction type N/A PTMCode2
THEM4 AKT1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HNRNPL THEM4 25348397 N/A physical interaction ComPPI
PDK1 THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TOP3A THEM4 25348397 N/A physical interaction ComPPI
AKT1 THEM4 11598301 14525934 19541650 22309289 24234451 24670654 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
AURKAIP1 THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CARD9 THEM4 25348397 N/A physical interaction ComPPI
KLC2 THEM4 25348397 N/A physical interaction ComPPI
HSPD1 THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GSTT2 THEM4 25348397 N/A physical interaction ComPPI
MGST3 THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
ENOPH1 THEM4 25348397 N/A physical interaction ComPPI
ALAS1 THEM4 25348397 N/A physical interaction ComPPI
THEM4 GPT2 25348397 N/A physical interaction ComPPI
THEM4 PDSS1 25348397 N/A physical interaction ComPPI
THEM4 PDSS2 25348397 N/A physical interaction ComPPI
THEM4 DBT 25348397 N/A physical interaction ComPPI
THEM4 FPGS 25348397 N/A physical interaction ComPPI
THEM4 SIRT5 25348397 N/A physical interaction ComPPI
THEM4 PRORP 25348397 N/A physical interaction ComPPI
THEM4 CLDN18 25348397 N/A physical interaction ComPPI
TRMT61B THEM4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
THEM4 AKT1 11598301 22309289 27898060 inhibition N/A OmniPath

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