Gene Information gene info

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GENE：TMC8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TMC8
FullNmae transmembrane channel like 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:20474
EnsembleID ENSG00000167895
Uniprot Q8IU68

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TMC8 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TMC8 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TMC8 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
TMC8 GO:0005515,GO:0005615,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0006882,GO:0008381,GO:0031333,GO:0031965,GO:0032091,GO:0034220,GO:0043120,GO:0070062,GO:0140311,GO:1902041

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 TMC8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TMC8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A TMC8 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 TMC8 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000237AF9 TMC8 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TRAF1 TMC8 25348397 N/A physical interaction ComPPI
TRAF2 TMC8 25348397 N/A physical interaction ComPPI

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