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GENE：HADHA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HADHA
FullNmae hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4801
EnsembleID ENSG00000084754
Uniprot P40939

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HADHA mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HADHA GO:0000062,GO:0003857,GO:0003985,GO:0004300,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0006635,GO:0006635,GO:0006635,GO:0009410,GO:0016507,GO:0016507,GO:0016509,GO:0018812,GO:0032868,GO:0035965,GO:0042645,GO:0044877,GO:0070403

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HADHA hsa:3030 path:hsa00062 Fatty acid elongation - Homo sapiens (human)
HADHA hsa:3030 path:hsa00071 Fatty acid degradation - Homo sapiens (human)
HADHA hsa:3030 path:hsa00280 Valine, leucine and isoleucine degradation - Homo sapiens (human)
HADHA hsa:3030 path:hsa00310 Lysine degradation - Homo sapiens (human)
HADHA hsa:3030 path:hsa00380 Tryptophan metabolism - Homo sapiens (human)
HADHA hsa:3030 path:hsa00410 beta-Alanine metabolism - Homo sapiens (human)
HADHA hsa:3030 path:hsa00640 Propanoate metabolism - Homo sapiens (human)
HADHA hsa:3030 path:hsa00650 Butanoate metabolism - Homo sapiens (human)
HADHA hsa:3030 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HADHA hsa:3030 path:hsa01212 Fatty acid metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HADHA EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
HADHA CXCR4 17715399 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDK2 HADHA 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ESR1 HADHA 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 HADHA 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 HADHA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HADHA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA HADHA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HADHA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HADHA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HADHA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HADHA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000070B1D HADHA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004505E4 HADHA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 HADHA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE HADHA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 HADHA 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
HADHB HADHA 25361965 interaction type N/A PTMCode2
HADHA HADHB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 HADHA 25348397 N/A physical interaction ComPPI
CDC73 HADHA 25348397 N/A physical interaction ComPPI
RELL2 HADHA 25348397 N/A physical interaction ComPPI
TOMM22 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FASTKD3 HADHA 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
EMD HADHA 25348397 N/A physical interaction ComPPI
TRAF6 HADHA 14743216 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,tandem affinity purification ComPPI,IntAct
GABARAPL2 HADHA 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
KEAP1 HADHA 25348397 N/A physical interaction ComPPI
MCM2 HADHA 25348397 N/A physical interaction ComPPI
MAP1LC3B HADHA 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MRPL40 HADHA 25348397 N/A physical interaction ComPPI
PLOD3 HADHA 25348397 N/A physical interaction ComPPI
CD44 HADHA 25348397 N/A physical interaction ComPPI
BTK HADHA 21080425 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
FBXW7 HADHA 25348397 N/A physical interaction ComPPI
PPP1R15A HADHA 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
JUN HADHA 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SPART HADHA 19765186 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
SDC2 HADHA 25348397 N/A physical interaction ComPPI
TUBG1 HADHA 25348397 N/A physical interaction ComPPI
UBC HADHA 25348397 N/A physical interaction ComPPI
NTRK1 HADHA 25348397 N/A physical interaction ComPPI
CANX HADHA 24234451 25348397 29568061 association pull down ComPPI,IntAct
CDH5 HADHA 25348397 N/A physical interaction ComPPI
YBX1 HADHA 24234451 25348397 25497084 association anti bait coimmunoprecipitation ComPPI,IntAct
PTPN2 HADHA 25348397 N/A physical interaction ComPPI
PPP1CA HADHA 24234451 25348397 25593058 association anti bait coimmunoprecipitation ComPPI,IntAct
MYC HADHA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TNFRSF1A HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
VDAC1 HADHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NFATC2 HADHA 25348397 N/A physical interaction ComPPI
SQSTM1 HADHA 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAQ HADHA 25348397 N/A physical interaction ComPPI
RPS6 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CSNK2A2 HADHA 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATP1B1 HADHA 25348397 N/A physical interaction ComPPI
CDK2 HADHA 25348397 N/A physical interaction ComPPI
TUBA1A HADHA 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
NR4A1 HADHA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MED23 HADHA 25348397 N/A physical interaction ComPPI
GABARAP HADHA 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
MAP1LC3A HADHA 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBB4B HADHA 25348397 N/A physical interaction ComPPI
WWOX HADHA 25348397 N/A physical interaction ComPPI
RIPK3 HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CA9 HADHA 25348397 N/A physical interaction ComPPI
MSN HADHA 25348397 N/A physical interaction ComPPI
VCAM1 HADHA 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
CUL7 HADHA 25348397 N/A physical interaction ComPPI
H3C1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HDAC5 HADHA 25348397 N/A physical interaction ComPPI
PSMD4 HADHA 25348397 N/A physical interaction ComPPI
CAND1 HADHA 25348397 N/A physical interaction ComPPI
PDK1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NFKB2 HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HNRNPH1 HADHA 25348397 N/A physical interaction ComPPI
ESR2 HADHA 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
TOMM20 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PARK7 HADHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
SKI HADHA 25348397 N/A physical interaction ComPPI
TGOLN2 HADHA 24234451 25348397 29568061 association pull down ComPPI,IntAct
AURKAIP1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PRKAB1 HADHA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IQCB1 HADHA 21565611 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BET1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
USP49 HADHA 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
IKBKE HADHA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATXN2L HADHA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAN2 HADHA 25348397 N/A physical interaction ComPPI
BCAR3 HADHA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATF2 HADHA 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TES HADHA 25348397 N/A physical interaction ComPPI
CDH8 HADHA 25348397 N/A physical interaction ComPPI
MED4 HADHA 25348397 N/A physical interaction ComPPI
TOMM40 HADHA 25348397 N/A physical interaction ComPPI
HSPD1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CD74 HADHA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSD17B10 HADHA 25348397 N/A physical interaction ComPPI
GABARAPL1 HADHA 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
POU5F1 HADHA 25348397 N/A physical interaction ComPPI
COX4I1 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MGST3 HADHA 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SIRT7 HADHA 25348397 N/A physical interaction ComPPI
NDUFB8 HADHA 25348397 N/A physical interaction ComPPI
KSR1 HADHA 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
LEO1 HADHA 25348397 N/A physical interaction ComPPI
ETFA HADHA 25348397 N/A physical interaction ComPPI
MAP3K1 HADHA 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HADHB HADHA 25348397 N/A physical interaction ComPPI
FN1 HADHA 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
EPB41 HADHA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HLA-B HADHA 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CAPZA2 HADHA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RTF1 HADHA 25348397 N/A physical interaction ComPPI
PPP6R1 HADHA 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
E2F3 HADHA 22157815 24234451 25348397 association pull down ComPPI,IntAct
PTPRD HADHA 25348397 N/A physical interaction ComPPI
RIPK4 HADHA 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
NIPSNAP2 HADHA 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HADHA ATG101 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HADHA MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HADHA STT3B 25348397 N/A physical interaction ComPPI
HADHA ZFR 25348397 N/A physical interaction ComPPI
HADHA ABCF2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HADHA ZBTB1 25348397 N/A physical interaction ComPPI
HADHA GRSF1 25348397 N/A physical interaction ComPPI
HADHA CCDC8 25348397 N/A physical interaction ComPPI
HADHA ATL3 25348397 N/A physical interaction ComPPI
HADHA EPHX1 25348397 N/A physical interaction ComPPI
HADHA NAF1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HADHA ZNF746 25348397 N/A physical interaction ComPPI
HADHA MEX3C 22863774 24234451 25348397 association pull down ComPPI,IntAct
HADHA SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
HADHA PPM1G 24234451 25348397 28330616 association pull down ComPPI,IntAct
HADHA PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
HADHA COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DDA1 HADHA 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HADHA MYO7B 24234451 30021884 physical association cross-linking study IntAct
HADHA KIF1C 24234451 30021884 physical association cross-linking study IntAct
ATP5PD HADHA 24234451 30021884 physical association cross-linking study IntAct
HADHA SIRT5 24234451 30021884 physical association cross-linking study IntAct
HADHA DNAI7 24234451 30021884 physical association cross-linking study IntAct
HADHA QRICH1 24234451 30021884 physical association cross-linking study IntAct
HADHA ENTHD1 24234451 30021884 physical association cross-linking study IntAct
HADHA TNS2 24234451 30021884 physical association cross-linking study IntAct
L1TD1 HADHA 24234451 25702638 association anti bait coimmunoprecipitation IntAct
CXCR4 HADHA 17715399 27898060 N/A N/A OmniPath

Visualization










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