GENE：ATOX1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ATOX1 |
| FullNmae | antioxidant 1 copper chaperone |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:798 |
| EnsembleID | ENSG00000177556 |
| Uniprot | O00244 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ATOX1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATOX1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATOX1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ATOX1 | cuproptosis | 40393577 | Silencing ATOX1 led to cuproptosis and mitochondrial dysfunction in HCC cells. | retulator signature |
| ATOX1 | cuproptosis | 36882769 | The copper was transported to another side of epithelium through copper chaperone antioxidant 1 copper chaperone (ATOX1) and exported into the bloodstream through the action of ATPase copper transporting alpha (ATP7A) | copper chaperone |
| ATOX1 | cuproptosis | 36882769 | Cytoplasmic copper ion chaperones ATOX1 bind Cu(I) via two cysteine residues and transport it to the metal binding sites of ATP7B for further exportation. | copper ion chaperones |
| ATOX1 | cuproptosis | 38339398 | Antioxidant 1 Copper Chaperone (ATOX1):Binds to Cu+; part of copper metalation pathway | copper ionophores |
| ATOX1 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| ATOX1 | cuproptosis | 38348451 | ATOX1 is a crucial copper-binding protein involved in copper transport and regulation. Upon binding with copper ions, it guides copper to the appropriate cellular locations to perform its biological functions | CRGs in the cuproptosis pathway |
| ATOX1 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.37 database. |
| ATOX1 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| ATOX1 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| ATOX1 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
| ATOX1 | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ATOX1 | GO:0005507,GO:0005515,GO:0005829,GO:0005829,GO:0006825,GO:0006825,GO:0006878,GO:0006979,GO:0016530,GO:0016531,GO:0016531,GO:0032767,GO:0032767,GO:1903136 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ATOX1 | hsa:475 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ATOX1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | ATOX1 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| GATA3 | ATOX1 | 19559773 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | ATOX1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000065D58 | ATOX1 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000324096 | ATOX1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000250A40 | ATOX1 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E3523 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009A9A2 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002FC5B0 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B0F6 | ATOX1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000345DEB | ATOX1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | ATOX1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000036B845 | ATOX1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ATOX1 | ATP7B | 10497213 10557326 12763797 12968035 14525934 16573520 17919502 24234451 25348397 27898060 | physical association | two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct,OmniPath |
| ATOX1 | FKBP4 | 14525934 15133031 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| ATOX1 | ATP7A | 10497213 10557326 12679332 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| ATOX1 | CFAP410 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ATOX1 | GGPS1 | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ATOX1 | FAM118A | 24234451 25348397 25416956 | physical association | physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| ATOX1 | ARFIP1 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | CCS | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | CRIP1 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | DAZAP1 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | GALM | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | SOD1 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | TAGLN2 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | GSTT1 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| ATOX1 | COMP | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATOX1 | NECAB1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ATOX1 | ATOX1 | 10966647 14525934 | N/A | experimental interaction detection | HPRD |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00008B21F9 | ATOX1 | 27087310 | direct interaction,inhibition | N/A | NPInter |