Gene Information gene info

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GENE：IREB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IREB2
FullNmae iron responsive element binding protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6115
EnsembleID ENSG00000136381
Uniprot P48200

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IREB2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IREB2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IREB2 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IREB2 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IREB2 GO:0003723,GO:0003723,GO:0003994,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0006099,GO:0006101,GO:0006417,GO:0006782,GO:0006879,GO:0009791,GO:0030316,GO:0030350,GO:0030350,GO:0030350,GO:0034101,GO:0046872,GO:0048255,GO:0050892,GO:0051539,GO:0051649,GO:0060586

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR IREB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IREB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IREB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 IREB2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 IREB2 17521434 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 IREB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D IREB2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 IREB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000021D08 IREB2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 IREB2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 IREB2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 IREB2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 IREB2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F IREB2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 IREB2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 IREB2 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 IREB2 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000016C318 IREB2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000034E58D IREB2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000083D87 IREB2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 IREB2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 IREB2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB IREB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 IREB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 IREB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 IREB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 IREB2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 IREB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 IREB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 IREB2 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001597DC IREB2 19536157 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FBC84 IREB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C IREB2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F IREB2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005586D0 IREB2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000C85B2 IREB2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 IREB2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 IREB2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 IREB2 22135298 phosphorylation N/A PhosphoSite
CDK2 IREB2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CBSL IREB2 25348397 N/A physical interaction ComPPI
CIAO1 IREB2 25348397 N/A physical interaction ComPPI
CIAO2B IREB2 25348397 N/A physical interaction ComPPI
SLC9A3R1 IREB2 25348397 N/A physical interaction ComPPI
PSMA3 IREB2 25348397 N/A physical interaction ComPPI
YBX1 IREB2 12192037 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
TERT IREB2 25348397 N/A physical interaction ComPPI
UBA2 IREB2 25348397 N/A physical interaction ComPPI
TNPO1 IREB2 25348397 N/A physical interaction ComPPI
VHL IREB2 25348397 N/A physical interaction ComPPI
SF1 IREB2 25348397 N/A physical interaction ComPPI
ENSA IREB2 25348397 N/A physical interaction ComPPI
CCNL2 IREB2 25348397 N/A physical interaction ComPPI
FBXL5 IREB2 25348397 N/A physical interaction ComPPI
INSL3 IREB2 25348397 N/A physical interaction ComPPI
ARL15 IREB2 25348397 N/A physical interaction ComPPI
CBS IREB2 25348397 N/A physical interaction ComPPI
USP53 IREB2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CIAO2A IREB2 25348397 N/A physical interaction ComPPI
RBCK1 IREB2 12629548 17822790 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ELAVL2 IREB2 25348397 N/A physical interaction ComPPI
IREB2 APP 25348397 N/A physical interaction ComPPI
IREB2 CAMKMT 25348397 N/A physical interaction ComPPI
IREB2 ALDH3B1 25348397 N/A physical interaction ComPPI
NDUFA9 IREB2 24234451 30021884 physical association cross-linking study IntAct
MCCC1 IREB2 24234451 30021884 physical association cross-linking study IntAct
H1-5 IREB2 24234451 30021884 physical association cross-linking study IntAct
CDK1 IREB2 18574241 27898060 inhibition N/A OmniPath
CDC14A IREB2 18574241 27898060 stimulant N/A OmniPath

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