GENE：SLC31A1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC31A1 |
| FullNmae | solute carrier family 31 member 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11016 |
| EnsembleID | ENSG00000136868 |
| Uniprot | O15431 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC31A1 | mpt | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC31A1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC31A1 | cuproptosis | 36276096 | This study aimed to evaluate the pan-cancer genomics and clinical association of cuproptosis and copper metabolism-related cell death genes, including SLC25A3, SLC25A37, SLC31A1, FDX1, DLAT, LIAS, ATP7A, ATP7B, COX17, SCO1, SCO2, COX11, and COX19. | retulator signature |
| SLC31A1 | cuproptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SLC31A1 | cuproptosis | 36882769 | Copper uptake occurs mainly through the small intestine, the small intestine epithelium took up copper ions via copper transporter 1 (CTR1) or called solute carrier family 31 member 1(SLC31A1), the transporter encoding by slc31a1 on the cell surface. | Copper uptake |
| SLC31A1 | cuproptosis | 36882769 | The entry and departure of copper ions into and out of the cell are controlled by the copper ion transporters SLC31A1 and ATP7B, whereas the transit of copper ions through the outer and inner mitochondrial membranes is controlled by COX17 and SLC25A3, respectively. | transporters |
| SLC31A1 | cuproptosis | 36882769 | The uptake of copper ions by tumor cells also requires the involvement of CTR1, and the elevated and decreased expression levels of SLC31A2 directly affect intracellular copper ion levels. | Copper uptake |
| SLC31A1 | cuproptosis | 36882769 | overactivaiton lead to intracellular copper accumulation. | Driver |
| SLC31A1 | cuproptosis | 38168558 | Among the CRGs in our study, 7 genes were pro-cuproptosis genes (FDX1, LIPT1, LIAS, DLD, PDHA1, DLAT and PDHB), 3 genes were anti-cuproptosis genes (MTF1, CDKN2A and GLS), and 2 genes were copper transporters (SLC31A1 and ATP7B). | copper transporters |
| SLC31A1 | cuproptosis | 38495196 | Cuproptosis-related genes were manually curated, and differentially expressed cuproptosis-related genes (DECuGs) were identified.Then, the 16 DECuGs were obtained by the intersection of the 5018 DEGs and 63 cuproptosis-related genes. | 63 cuproptosis-related genes |
| SLC31A1 | cuproptosis | 38348451 | Copper transporters. Essential for copper homeostasis and their dysregulation can influence cuproptosis susceptibility. | CRGs in the cuproptosis pathway |
| SLC31A1 | cuproptosis | 35964468 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | Cuproptosis-related gene sets obtained from Molecular Signature Database (MsigDB) v7.28 database. |
| SLC31A1 | cuproptosis | 35996075 | Cuproptosis-related gene sets were obtained from a previous study [9] and combined with the Molecular Signature Database (MsigDB) v7.0 database (http://www.gsea-msigdb.org/gsea/msigdb/, GOBP_CELLULAR_COPPER_ION_HOMEOSTASIS, GOBP_CELLULAR_RESPONSE_TO_COPPER_ION). | driver |
| SLC31A1 | cuproptosis | 36313717 | The details of ninety-six candidate cuproptosis-related genes involved in the copper homeostasis regulatory pathway, copper metabolism diseases, mitochondrial respiratory, and iron-sulfur cluster proteins were exhibited in Table S1. | Genes related to copper homeostasis pathway |
| SLC31A1 | cuproptosis | 36211378 | Forty-three cuproptosis-related genes were selected from the review of Chang et al. (13) | 43 cuproptosis-related genes in the study |
| SLC31A1 | cuproptosis | 36118866 | Promotor | cuproptosis gene |
| SLC31A1 | cuproptosis | 36685880 | A total of 43 CRGs were manually identified and used to investigate the effects of cuproptosis in HNSC in current study. | cuproptosis-related genes |
| SLC31A1 | cuproptosis | 36568423 | Additionally, 41 cuproptosis regulators were obtained from the previous publications. | cuproptosis-related genes |
| SLC31A1 | cuproptosis | 36505872 | A total of 44 cuproptosis-related genes were extracted from known literature. | cuproptosis-related genes |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC31A1 | GO:0001525,GO:0001525,GO:0005375,GO:0005375,GO:0005507,GO:0005515,GO:0005886,GO:0005886,GO:0006825,GO:0006878,GO:0014704,GO:0015080,GO:0015080,GO:0015677,GO:0015677,GO:0015679,GO:0016323,GO:0016324,GO:0031901,GO:0031902,GO:0036324,GO:0042802,GO:0042908,GO:0042908,GO:0042910,GO:0051259,GO:0051649,GO:0055038,GO:1902601,GO:1902601 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC31A1 | hsa:1317 | path:hsa01524 | Platinum drug resistance - Homo sapiens (human) |
| SLC31A1 | hsa:1317 | path:hsa04978 | Mineral absorption - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC31A1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | SLC31A1 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | SLC31A1 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXP3 | SLC31A1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SLC31A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC31A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC31A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC31A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC31A1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | SLC31A1 | 20159940 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | SLC31A1 | 20159940 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | SLC31A1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000009262D | SLC31A1 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000345DEB | SLC31A1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000083D87 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D0874 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000239117 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075D50C | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00006097A6 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002367FA | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001383CF | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ECFE5 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000939AF | SLC31A1 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | SLC31A1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003677B2 | SLC31A1 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000013DD8 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F8DA | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004AF715 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075C1E1 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | SLC31A1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | SLC31A1 | 25416803 27270317 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| HNRNPL | SLC31A1 | 25348397 | N/A | physical interaction | ComPPI |
| CD70 | SLC31A1 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS8 | SLC31A1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | SLC31A1 | 25348397 | N/A | physical interaction | ComPPI |
| CCS | SLC31A1 | 25348397 | N/A | physical interaction | ComPPI |
| SLC31A1 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| SLC31A1 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| SLC31A1 | ERBB3 | 25348397 | N/A | physical interaction | ComPPI |
| SLC31A1 | PLXDC2 | 25348397 | N/A | physical interaction | ComPPI |
| SLC31A1 | NCR3LG1 | 25348397 | N/A | physical interaction | ComPPI |