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GENE：STEAP4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol STEAP4
FullNmae STEAP4 metalloreductase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21923
EnsembleID ENSG00000127954
Uniprot Q687X5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
STEAP4 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
STEAP4 cuproptosis 37055935 Inflammatory cytokine IL17 (interleukin 17) increases intracellular copper by inducing STEAP4 (STEAP4 metalloreductase) in colon cancer. retulator signature
STEAP4 cuproptosis 38299968 Their findings indicated that androgens can augment the transcriptional levels of CTR1, ATP7B, and STEAP4 by activating ARs, thereby increasing the cellular uptake of copper. incucer

Go Annotation:

GeneSymbol Go id
STEAP4 GO:0000139,GO:0005654,GO:0005768,GO:0005886,GO:0005886,GO:0005886,GO:0008823,GO:0009055,GO:0015677,GO:0016020,GO:0020037,GO:0022900,GO:0031901,GO:0033212,GO:0034755,GO:0045444,GO:0046872,GO:0052851,GO:0052851,GO:0070062,GO:0070207,GO:0071949

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR STEAP4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 STEAP4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000521626 STEAP4 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000157026 STEAP4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003E226A STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000015188E STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CE0C6 STEAP4 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TERT STEAP4 25348397 N/A physical interaction ComPPI
AKT2 STEAP4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AR STEAP4 15897894 27898060 stimulant N/A OmniPath

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