Gene Information gene info

  1. Home

GENE：DISC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DISC1
FullNmae DISC1 scaffold protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2888
EnsembleID ENSG00000162946
Uniprot Q9NRI5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DISC1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DISC1 GO:0000226,GO:0001764,GO:0001764,GO:0001954,GO:0002052,GO:0005515,GO:0005739,GO:0005739,GO:0005813,GO:0005813,GO:0005829,GO:0005871,GO:0005874,GO:0006511,GO:0008021,GO:0010976,GO:0014069,GO:0019894,GO:0021846,GO:0021852,GO:0030177,GO:0030286,GO:0031929,GO:0032091,GO:0036064,GO:0042802,GO:0044297,GO:0044877,GO:0045111,GO:0045111,GO:0045773,GO:0048471,GO:0051560,GO:0051602,GO:0051966,GO:0060070,GO:0060090,GO:0060271,GO:0060998,GO:0070050,GO:0071539,GO:0090128,GO:0090724,GO:0097546,GO:0098793,GO:0098978,GO:0098982,GO:0099175,GO:1905515,GO:2000060

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TUBB DISC1 17043677 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
AR DISC1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 DISC1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 DISC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 DISC1 12812986 trascriptional regulation,stimulation inferred by curator TFlink
ATF5 DISC1 12812986 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075A760 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00002152A8 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000037E170 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001C770D DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000EC1BE DISC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE DISC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E DISC1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000007F792 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000122ED0 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000032EF64 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000237CBD DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000029979D DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS000000B1C9 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000A07C1 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000031E12 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000324096 DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00000AB32B DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS00001496AE DISC1 23592263 25416803 26701625 27292025 mrna cleavage,inhibition clip TarBase
URS0000204177 DISC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002E1509 DISC1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DISC1 TSN 25361965 interaction type N/A PTMCode2
TSN DISC1 25361965 interaction type N/A PTMCode2
GOLGA3 DISC1 25361965 interaction type N/A PTMCode2
DISC1 GOLGA3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KANSL1 DISC1 25348397 N/A physical interaction ComPPI
SMARCE1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC5L DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF3H DISC1 12812986 14525934 17043677 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
STX11 DISC1 25348397 N/A physical interaction ComPPI
ATF4 DISC1 12812986 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
ACTG1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBB DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAG DISC1 12506198 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
RAD21 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GPRASP2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BORCS6 DISC1 25348397 N/A physical interaction ComPPI
CDK5RAP3 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYH7 DISC1 12812986 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FBXW7 DISC1 25348397 N/A physical interaction ComPPI
CELA1 DISC1 25348397 N/A physical interaction ComPPI
CDC16 DISC1 25348397 N/A physical interaction ComPPI
CIT DISC1 12506198 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
TRIO DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FEZ1 DISC1 12874605 14525934 25348397 27898060 N/A physical interaction,two hybrid ComPPI,HPRD,OmniPath
GSK3B DISC1 25348397 N/A physical interaction ComPPI
CLU DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KALRN DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
COL6A2 DISC1 12812986 24234451 25348397 physical association two hybrid ComPPI,IntAct
YWHAZ DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TUBG1 DISC1 12812986 24234451 25348397 colocalization,physical association cosedimentation,fluorescence microscopy ComPPI,IntAct
MVP DISC1 25348397 N/A physical interaction ComPPI
SNX6 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KIFAP3 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SPARCL1 DISC1 25348397 N/A physical interaction ComPPI
XRN2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NEFM DISC1 25348397 N/A physical interaction ComPPI
AKAP6 DISC1 25348397 N/A physical interaction ComPPI
DCTN1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NDE1 DISC1 25348397 N/A physical interaction ComPPI
SPTAN1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACTN2 DISC1 12812986 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RANBP9 DISC1 12812986 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
RBSN DISC1 25348397 N/A physical interaction ComPPI
RABGAP1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UTRN DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNIK DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EXOC1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EXOC4 DISC1 25348397 N/A physical interaction ComPPI
DNAJC7 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAQ DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAFAH1B1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITSN1 DISC1 12812986 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SPTBN1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCNT DISC1 12812986 14525934 15094396 24234451 25348397 27898060 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation,experimental interaction detection,fluorescence microscopy,two hybrid ComPPI,HPRD,IntAct,OmniPath
COL4A1 DISC1 25348397 N/A physical interaction ComPPI
YWHAE DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SKP2 DISC1 25348397 N/A physical interaction ComPPI
KCNQ5 DISC1 12506198 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
SMC3 DISC1 25348397 N/A physical interaction ComPPI
AGTPBP1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CEP126 DISC1 12812986 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZNF197 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SH3BP5 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SYNE1 DISC1 12812986 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
PGK1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TFIP11 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DYNC1H1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDE4B DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MLLT10 DISC1 25348397 N/A physical interaction ComPPI
IMMT DISC1 17043677 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,far western blotting,pull down,physical interaction ComPPI,IntAct
SPTBN4 DISC1 12506198 12812986 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
PPP5C DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TNKS DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DPYSL3 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SYNM DISC1 24234451 25348397 25447537 physical association two hybrid ComPPI,IntAct
TNKS2 DISC1 22153077 24234451 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
NDEL1 DISC1 12506198 12812986 14525934 17043677 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,far western blotting,physical interaction,fluorescence microscopy,two hybrid ComPPI,HPRD,IntAct
DPYSL2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SRGAP3 DISC1 25348397 N/A physical interaction ComPPI
TRAF3IP1 DISC1 12812986 14525934 17043677 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,two hybrid ComPPI,HPRD,IntAct
PPP4R1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EEF2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SRGAP2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MYF6 DISC1 25348397 N/A physical interaction ComPPI
MACF1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KIF3C DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DCTN2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATF5 DISC1 12812986 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,two hybrid ComPPI,HPRD,IntAct
IFT20 DISC1 25348397 N/A physical interaction ComPPI
P4HA2 DISC1 25348397 N/A physical interaction ComPPI
P4HA3 DISC1 25348397 N/A physical interaction ComPPI
RTRAF DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSPOAP1 DISC1 25348397 N/A physical interaction ComPPI
GNB1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUP160 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARIH2 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SYBU DISC1 25348397 N/A physical interaction ComPPI
CCDC136 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCDC88A DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
STX18 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PCNX4 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CEP63 DISC1 12812986 17043677 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
ROGDI DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CEP170 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPM1E DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
XPNPEP1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TCL1B DISC1 25348397 N/A physical interaction ComPPI
CCDC141 DISC1 12812986 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CRNKL1 DISC1 17043677 24234451 25348397 physical association two hybrid ComPPI,IntAct
ZNF365 DISC1 25348397 N/A physical interaction ComPPI
TIAM2 DISC1 25348397 N/A physical interaction ComPPI
CRYBA4 DISC1 25348397 N/A physical interaction ComPPI
RASSF7 DISC1 12812986 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HERC2 DISC1 17043677 24234451 25348397 physical association two hybrid ComPPI,IntAct
MEMO1 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATF7IP DISC1 12812986 14525934 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
DMD DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
AKAP9 DISC1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 MAP1A 12812986 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,IntAct
DISC1 FBXO41 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 MYT1L 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 CCDC24 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 FRYL 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 KIF3A 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 MATR3 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 CEP57L1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 DST 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 TUBB2A 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 OLFM1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 SMC2 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 ZNF365 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 BICD1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 GNPTAB 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 EXOC7 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 MPPED1 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DISC1 SRR 25348397 N/A physical interaction ComPPI
DISC1 RIBC1 25348397 N/A physical interaction ComPPI
DISC1 DYNC1I1 25348397 N/A physical interaction ComPPI
DISC1 ASB3 25348397 N/A physical interaction ComPPI
DISC1 ANKHD1 25348397 N/A two hybrid ComPPI
DISC1 DISC1 12812986 14525934 N/A experimental interaction detection,two hybrid HPRD
DISC1 NDEL1 12506198 12812986 14962739 17043677 17202468 20880836 27898060 stimulant N/A OmniPath
DISC1 KIF5B 17202468 27898060 stimulant N/A OmniPath
DISC1 PAFAH1B1 17043677 17202468 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS000075F11A DISC1 10814723 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return