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GENE：ALAS2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ALAS2
FullNmae 5'-aminolevulinate synthase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:397
EnsembleID ENSG00000158578
Uniprot P22557

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ALAS2 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ALAS2 GO:0001666,GO:0003870,GO:0003870,GO:0003870,GO:0005515,GO:0005739,GO:0005739,GO:0005743,GO:0005759,GO:0006782,GO:0006783,GO:0006783,GO:0006783,GO:0006879,GO:0030170,GO:0030218,GO:0030218,GO:0032364,GO:0042541,GO:0042541,GO:0048821

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ALAS2 hsa:212 path:hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human)
ALAS2 hsa:212 path:hsa00860 Porphyrin metabolism - Homo sapiens (human)
ALAS2 hsa:212 path:hsa01100 Metabolic pathways - Homo sapiens (human)
ALAS2 hsa:212 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ELANE ALAS2 19506020 23180781 physical association two hybrid InnateDB
ALAS2 BANP 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 ALAS2 19941826 23935018 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ALAS2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A ALAS2 21207956 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ALAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ALAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ALAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ALAS2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
RABGGTB ALAS2 14525934 25348397 27898060 546546 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
GRB2 ALAS2 18624398 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BANP ALAS2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SUCLA2 ALAS2 10727444 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath

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